Noninvasive measurement of regional cerebral blood flow change with H/sub 2//sup 15/O and positron emission tomography using a mechanical injector and a standard arterial input function

Sadato, Norihiro; Yonekura, Y; Senda, Michio; Magata, Yasuhiro; Iwasaki, Yasushi; Matoba, N; Tsuchida, Tatsuro; Tamaki, Nagara; Fukuyama, Hidenao; Shibasaki, Hiroshi; Konishi, Junji

doi:10.1109/42.251121

Cited by 19 publications

(3 citation statements)

References 15 publications

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“…The dedicated PET camera, HEADTOME IV (Shimadzu, Kyoto, Japan), provides 14 slices of tomographic images at 6.5-mm intervals with spatial resolution of 7.5-mm full-width-halfmaximum (FWHM) and axial resolution of 10-mm FWHM. The CBF images were created using the autoradiographic method with a standard input function [16], [17]. The CBF images of each subject were three-dimensionally registered to the MRI of the subject [18].…”

Section: B Pet Activation Study and Mrimentioning

confidence: 99%

Mapping visual field with positron emission tomography by mathematical modeling of the retinotopic organization in the calcarine cortex

Endo

Toyama

Kimura³

et al. 1997

IEEE Trans. Med. Imaging

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We developed an objective and quantitative method of mapping the human visual field with positron emission tomography (PET) and magnetic resonance image (MRI). The regional cerebral blood flow (rCBF) images were acquired with H2(15)O-PET under visual fixation as well as under visual stimulation with flickering diodes arranged along the ring at 0 degree, 3 degrees, 7 degrees, 14 degrees, 21 degrees, or 29 degrees from the fixation point. After coregistration of PET and MR images, we extracted the surface of the calcarine cortex from the MR images and unfolded it to a two-dimensional (2-D) elliptic plane, on which the activated PET images were superimposed. Then we transformed the unfolded calcarine cortex into the visual field coordinates using the complex logarithmic function proposed by Schwartz. A large individual variation was observed in the retinotopical organization as well as in the morphology of the calcarine cortex. The formula was valid only within 15 degrees from the center of the visual field. The constant parameter in the formula was estimated to be 1.5. The cortical linear magnification factor was 12.1, 2.8, and 1.6 at 0, 5, and 10 degrees, respectively. The areas of the central 10 degrees and 40 degrees in the visual field correspond to 50% and 81% of the calcarine surface, respectively.

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Section: B Pet Activation Study and Mrimentioning

confidence: 99%

Mapping visual field with positron emission tomography by mathematical modeling of the retinotopic organization in the calcarine cortex

Endo

Toyama

Kimura³

et al. 1997

IEEE Trans. Med. Imaging

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“…0-15 labeled water (in total 6 ml saline solution) was injected via the right cubital vein in 15 seconds with an automatic injector. 9 The volume and activity of the residual radiotracer in the syringe were measured and corrected for decay to obtain the injected dose. The injected activity ranged from 11 to 39 mCi (410 to 1440 MBq).…”

Section: Tomograph Characteristicsmentioning

confidence: 99%

Optimal dose of injection in activation study with O-15 water and PET

et al. 1994

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In activation studies with the bolus method for O-15 water and PET, the radiotracer concentration may reach the limits of the system in terms of dead time correction and accidental coincidence. To obtain the optimal injection dose of O-15 water, we performed a normal volunteer study to evaluate the relationship between the injected dose and the radioactivity concentration in the brain and a phantom study to evaluate the performance of the PET scanner (PCT3600W) under high count rate conditions and the effect of averaging on the signal to noise ratio for the PET images. A linear relationship was noted between the injected dose (normalized for each body weight: x) and the mean radiotracer concentration in the brain measured by PET (y) (y = 2.52 + 30.1 x, n = 64, r = 0.87, p < 0.001). The percent error in the measurement of radioactivity with PET was within +/- 5% in the 100 to 2000 nCi/ml (3.7-74 KBq/ml) range. Below 100 nCi/ml (3.7 KBq/ml), the percent error increased due to the rapid increase in noise in the reconstructed images. Over 1000 nCi/ml (37 KBq/ml), on the other hand, the noise was almost unchanged. With our PET scanner, the optimal range of the radiotracer concentration in the brain is below 1000 nCi/ml (37 KBq/ml), corresponding to an injection dose of 33 mCi (1.22 GBq)/60 kg body weight. With the same total dose, the increment of number of repeated measurements for averaging provided the better signal to noise ratio. In designing a paradigm for an activation PET study, the injection dose and the number of repeated measurements for averaging should be considered.

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“…The final technique is to use a standard input function (averaged over several normal controls) to calculate the physiological parameters [11] [12]. There has also been considerable interest in modeling the input function [13] [14].…”

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A non-invasive LSO-APD blood radioactivity monitor for PET imaging studies

Shokouhi¹,

Stoll²,

Villanueva³

et al.

2002 IEEE Nuclear Science Symposium Conference Record

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A study has been carried out to investigate the possibility of using a pair of LSO + APD detector arrays to obtain a non-invasive measurement of the arterial input function for use in PET. The main focus of this study was to determine the spatial resolution and sensitivity required to obtain a high quality image that would permit a precise determination of the region of interest around the wrist artery. From these data a quantitative arterial input function that has minimal interference from the tissue and vein background can be obtained. The detector arrays were operated in coincidence counting mode to obtain planar images of various phantoms to demonstrate the feasibility of the concept.

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Noninvasive measurement of regional cerebral blood flow change with H/sub 2//sup 15/O and positron emission tomography using a mechanical injector and a standard arterial input function

Cited by 19 publications

References 15 publications

Mapping visual field with positron emission tomography by mathematical modeling of the retinotopic organization in the calcarine cortex

Mapping visual field with positron emission tomography by mathematical modeling of the retinotopic organization in the calcarine cortex

Optimal dose of injection in activation study with O-15 water and PET

A non-invasive LSO-APD blood radioactivity monitor for PET imaging studies

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