Noninvasive Measurement of Regional Cerebral Blood Flow by Near-Infrared Spectroscopy and Indocyanine Green

Kuebler, Wolfgang M.; Sckell, Axel; Häbler, O.; Kleen, M.; Kuhnle, G. E. H.; Welte, M.; Meßmer, K.; Goetz, Alwin E.

doi:10.1097/00004647-199804000-00013

Cited by 183 publications

(154 citation statements)

References 61 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Diffuse optical tomographic (DOT) and spectroscopic (DOS/NIRS) methods have been demonstrated to measure tissue blood volume, blood oxygenation and changes thereof, in both research and clinical settings. In some cases, one can obtain information about blood flow with DOS, but this information is derived indirectly [56,57]. The development of DCS now enables clinicians to measure several haemodynamic parameters independently with non-invasive optical probes (i.e.…”

Section: Introductionmentioning

confidence: 99%

Direct measurement of tissue blood flow and metabolism with diffuse optics

Mesquita

Durdurán

et al. 2011

Phil. Trans. R. Soc. A.

175

189

View full text Add to dashboard Cite

Diffuse optics has proven useful for quantitative assessment of tissue oxy-and deoxyhaemoglobin concentrations and, more recently, for measurement of microvascular blood flow. In this paper, we focus on the flow monitoring technique: diffuse correlation spectroscopy (DCS). Representative clinical and pre-clinical studies from our laboratory illustrate the potential of DCS. Validation of DCS blood flow indices in human brain and muscle is presented. Comparison of DCS with arterial spin-labelled MRI, xenon-CT and Doppler ultrasound shows good agreement (0.50 < r < 0.95) over a wide range of tissue types and source detector distances, corroborating the potential of the method to measure perfusion non-invasively and in vivo at the microvasculature level. Alloptical measurements of cerebral oxygen metabolism in both rat brain, following middle cerebral artery occlusion, and human brain, during functional activation, are also described. In both situations, the use of combined DCS and diffuse optical spectroscopy/near-infrared spectroscopy to monitor changes in oxygen consumption by the tissue is demonstrated. Finally, recent results spanning from gene expression-induced angiogenic response to stroke care and cancer treatment monitoring are discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Direct measurement of tissue blood flow and metabolism with diffuse optics

Mesquita

Durdurán

et al. 2011

Phil. Trans. R. Soc. A.

175

189

View full text Add to dashboard Cite

show abstract

“…A methodology based on measurement of diffuse reflec− tance combined with optical contrast agent tracking was developed for assessment of cerebral perfusion [30][31][32][33]. In this respect indocyanine green (ICG) is considered as a va− luable contrast agent revealing high absorption in near infra− red wavelength region [34] which can be safely [35] used in clinical studies [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Time-resolved multi-channel optical system for assessment of brain oxygenation and perfusion by monitoring of diffuse reflectance and fluorescence

Milej

Gerega

Kacprzak

et al. 2014

Opto-Electronics Review

View full text Add to dashboard Cite

Time-resolved near-infrared spectroscopy is an optical technique which can be applied in tissue oxygenation assessment. In the last decade this method is extensively tested as a potential clinical tool for noninvasive human brain function monitoring and imaging. In the present paper we show construction of an instrument which allows for: (i) estimation of changes in brain tissue oxygenation using two-wavelength spectroscopy approach and (ii) brain perfusion assessment with the use of single-wavelength reflectometry or fluorescence measurements combined with ICG-bolus tracking. A signal processing algorithm based on statistical moments of measured distributions of times of flight of photons is implemented. This data analysis method allows for separation of signals originating from extra- and intracerebral tissue compartments. In this paper we present compact and easily reconfigurable system which can be applied in different types of time-resolved experiments: two-wavelength measurements at 687 and 832 nm, single wavelength reflectance measurements at 760 nm (which is at maximum of ICG absorption spectrum) or fluorescence measurements with excitation at 760 nm. Details of the instrument construction and results of its technical tests are shown. Furthermore, results of in-vivo measurements obtained for various modes of operation of the system are presented.

show abstract

“…In 1998, Kuebler [15] used the NIRS data to calculate the blood flow index (BFI). Blood flow index (BFI) was defined as the coefficient between maximum ICG signal obtained by NIRS and the rise time.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Mudra

Muroi

Niederer

et al. 2008

Opto-Electronics Review

View full text Add to dashboard Cite

The cerebral blood flow (CBF) is an important vital parameter in neurointensive care. Currently, there is no non-invasive method for its measurement that can easily be applied at the bedside. A new tool to determine CBF is based on near-infrared spectroscopy (NIRS) applied together with indocyanine green (ICG) dye dilution. From a bilateral measurement on selected regions on the head of infrared (IR) absorption at various wavelengths during the dilution maneuver, the vascular perfusion characteristics of the two brain hemispheres can be determined in terms of mean transit time (mtt) of ICG, cerebral blood volume (CBV) and CBF.So far, on nine healthy volunteers, NIRS ICG dye dilution bihemispheric measurements were performed, which yielded to mtt given as median (range) of 9.3 s (5.1–16.3 s), CBV of 3.5 ml/100 g (1.7–4.1 ml/100 g), and CBF of 18.2 ml/(100 g×min) [11.1–48.6 ml/(100 g×min)]. Additionally, the blood flow index (BFI) was calculated with BFI= 13.8 mg/(100 g×s) [6.6–15.2 mg/(100 g×s)]. The Spearman rank correlation coefficient between CBF and BFI was RS = 0.76. However, as the Bland & Altman plot between CBFNIRS and the CBFBFI documents, the limits of agreement are rather wide (21.9±6.7). Under physiological conditions in healthy volunteers, no differences could be detected between the hemispheres.

show abstract

Noninvasive Measurement of Regional Cerebral Blood Flow by Near-Infrared Spectroscopy and Indocyanine Green

Cited by 183 publications

References 61 publications

Direct measurement of tissue blood flow and metabolism with diffuse optics

Direct measurement of tissue blood flow and metabolism with diffuse optics

Time-resolved multi-channel optical system for assessment of brain oxygenation and perfusion by monitoring of diffuse reflectance and fluorescence

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Contact Info

Product

Resources

About