Noninvasive measurement of lower extremity muscle oxygen extraction fraction under cuff compression paradigm

Abstract

This susceptibility-based OEF quantification technique together with cuff compression paradigm could provide a noninvasive, quantifiable and effective tool for measuring skeletal muscle oxygenation.

Quantitative Magnetic Resonance Imaging Assessment of the Quadriceps Changes during an Extreme Mountain Ultramarathon

“…The magnetic susceptibility  remained very stable with only a minimal increase at arrival of 1.75±0.43 ppm vs. 1.49±0.34 ppm at baseline (see Supplemental Digital Content 8, Values of urinary and blood biomarkers at 4 time points), as expected in low-intensity aerobic exercisewhere the average intensity remains below 50% of VO2max(56), explaining the lack of significant variations over time. Indeed, measurable changes in magnetic susceptibility-related measures in skeletal muscles reported in the literature occurred only in critical conditions such as cuff compression tests or ischemia(71). Our differences among muscle heads and groups are, however, in line with findings by others(71).…”

“…Indeed, measurable changes in magnetic susceptibility-related measures in skeletal muscles reported in the literature occurred only in critical conditions such as cuff compression tests or ischemia(71). Our differences among muscle heads and groups are, however, in line with findings by others(71). This finding is explained by the differences among muscles in slow-twitch oxidative muscle fibers, different capillary density, and myoglobin content.…”

Evaluation of skeletal muscle microvascular perfusion of lower extremities by cardiovascular magnetic resonance arterial spin labeling, blood oxygenation level-dependent, and intravoxel incoherent motion techniques

“…In our study, we did not measure continuous temporal changes of ASL, BOLD, and IVIM in our subjects mainly because it was not technically feasible to perform these three sequences sequentially at a high temporal resolution. Nevertheless, our protocol can be regarded as a simplified approach to the dynamic scanning method; a similar approach was also used in a previous study [ 38 ]. Although PHV and TTP proved useful for the assessment of PAD in most published studies, conflicting results also exist [ 13 ].…”

Monitoring clinical progression with mitochondrial disease biomarkers

“…Similar techniques to enable measurement of skeletal muscle OEF have already been applied in small cohorts of healthy individuals ( Zheng et al , 2014 ; Wang et al , 2016 ) and future assessment in patients with mitochondrial disorders would be relevant given the reduction in tissue oxygen extraction (peak arterial-venous oxygen difference) widely identified during sub-maximal exercise tests in these cohorts ( Taivassalo et al , 2006 ). Should the muscle OEF technique be further assessed and validated, it could have advantage over submaximal exercise testing in a mitochondrial cohort because of its application to those unable to exercise, for example, those with significant weakness, cardiovascular disease, children or intellectual disabilities.…”