“…In three of the five unsuccessful cases, a safety algorithm caused the treatments to be automatically discontinued once the near-field or far-field temperature exceeded the predefined temperature safety limit (16); in the other two cases treatment failure was due to equipment malfunction. The mean standard deviation for the temperature in untreated regions was 1.1 6 0.2 C. The regions of real-time temperature change for all treatment cell sizes (4,8,12, and 16 mm) were roughly ellipsoidal, with the longest axis, as expected, being in the direction of propagation of the HIFU beam (as seen in the sagittal monitoring plane and in a circular cross-section in each of the three coronal treatment planes). Figure 3A-D presents the complete sequence of steps, including imaging on the planning console (Fig.…”