Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?

Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C

“…To ascertain or rule out a diagnosis, the physician decides upon additional tests based on findings in previous steps, to increase or decrease the probability of a target condition. We believe that diagnostic research should follow the sequential process of making a diagnosis in practice, and also aim to quantify the added value of a new test in relation to clinical information available from existing methods [19,20].…”