Noninvasive in vivo quantitative assessment of fat content in human liver

Ricci, Claudio; Longo, Renata; Gioulis, Eugenio; Bosco, Marcella; Pollesello, Piero; Masutti, Flora; Crocè, Lory Saveria; Paoletti, Sergio; Bernard, B. de; Tiribelli, Claudio; Palma, L. Dalla

doi:10.1016/s0168-8278(97)80288-7

Cited by 286 publications

(212 citation statements)

References 12 publications

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“…The specificity of this method could be increased up to 100% if known liver disease, drug use or alcohol consumption were ruled out. 89,90 However, US could not detect 7.4-8.8% of cases with NAFLD. However, the presence of fibrosis is not related to misdiagnosis.…”

Section: Ultrasonography (Us)mentioning

confidence: 95%

“…86 Table 3 presents results of the imaging techniques used in diagnosis of NAFLD-NASH. 86,[90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109] The underlying physical principle of imaging techniques are the same between adults and children. Consequently research in both age groups could be used to approve the use of these methods in pediatric field.…”

Section: Image Studiesmentioning

confidence: 99%

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Nonalcoholic fatty liver disease: a challenge for pediatricians

Widhalm

Ghods

2010

Int J Obes

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Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of pediatric liver disease. Its prevalence is related to the growing epidemic in childhood obesity during the past decades. At present, NAFLD and nonalcoholic steatohepatitis (NASH) are increasingly recognized worldwide. In spite of alarming trend in the epidemiology in pediatric field and growing risk of end stage liver disease, there is no significant advance in its diagnosis and treatment. Aim: To provide a detailed review for diagnosis and management of NAFLD and NASH. Methods: By using Pubmed to find review articles and relevant research. Results: The prevalence ranges from at least 3% in children overall to about 50% in obese children. The noninvasive biomarkers can be used to identify NAFLD/NASH patients. Diagnostic criteria based on biochemical and immunological indicators in the high-risk group of children could prevent about half of cases from receiving an invasive test. The pharmacological and surgical interventions have shown a growing role in pediatric NAFLD. Novel treatment modalities, such as probiotics, have hardly been studied. Conclusion: Early diagnosis by using noninvasive screening methods in high-risk groups is the most effective strategy against the NAFLD. The biology of early growth and development, including hepatic metabolism, may hold the key to pediatric NAFLD. Prevention of overweight children and childhood obesity is undoubtedly the best strategy for treating NAFLD.

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Section: Ultrasonography (Us)mentioning

confidence: 95%

Section: Image Studiesmentioning

confidence: 99%

Nonalcoholic fatty liver disease: a challenge for pediatricians

Widhalm

Ghods

2010

Int J Obes

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“…Previous studies have shown a strong correlation between the CT attenuation values of the liver and the extent of fatty infiltration of the liver as measured by liver biopsy [14,15]. The ratio of the CT attenuation value of the liver to that of the spleen (L/S ratio) has also been used for quantitative estimation of the hepatic fat content, with an L/S ratio of <1 being considered to represent fatty liver [14].…”

Section: Assessment Of the Hepatic Fat Contentmentioning

confidence: 99%

Relationship between the Serum Concentrations of C-reactive Protein and Parameters of Adiposity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus

et al. 2006

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Abstract. Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity and insulin resistance in both Japanese type 2 diabetes patients and non-diabetic subjects. A total of 248 Japanese subjects (140 type 2 diabetes patients and 108 non-diabetic subjects) were enrolled for the study. The degree of insulin resistance was estimated by the homeostasis model assessment (HOMA-R) method. Fat accumulation was evaluated by measuring visceral and subcutaneous fat areas at the level of the umbilicus in abdominal CT scans. To assess hepatic fat content, the ratio of CT attenuation value of the liver to that of the spleen (L/S ratio) was calculated. Serum CRP was found to be significantly correlated with various indices of adiposity, including L/S ratio, visceral fat area (VFA), subcutaneous fat area (SFA), and HOMA-R, in both the diabetic patients and the non-diabetic subjects. After adjustment for five variables (age, gender, serum CRP, HbA1c, and smoking), serum CRP was still significantly correlated with L/S ratio, VFA, SFA, and HOMA-R in the diabetic patients. We also found that changes in serum CRP concentrations were correlated with changes in the VFA and SFA at 1 year after the baseline in 24 diabetic patients. We conclude that serum CRP may be closely related to the degree of liver steatosis and visceral fat accumulation in Japanese type 2 diabetes mellitus patients.

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“…NAFLD was defined as a liver‐to‐spleen attenuation ratio of <0.92, 3, 14 or a hepatic attenuation value at least 10 Hounsfield units lower than the spleen attenuation value2, 15 on unenhanced abdominal CT scan. We used average CT attenuation values in four sectors of the liver and the median value from all sections of the spleen (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy

Fujii

Nanashima

Hiyoshi

et al. 2017

Annals of Gastroent Surgery

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Considerable attention has been focused on nonalcoholic fatty liver disease (NAFLD) which occasionally develops after pancreatoduodenectomy (PD). The present study aimed to clarify the prevalence, sequential change in properties and risk factors for NAFLD development after PD. We enrolled 196 patients who underwent PD and a computed tomography (CT) scan 1 month, 6 months and 1 year after surgery. NAFLD was defined as a liver‐to‐spleen attenuation ratio on plain CT of <0.9. We compared various clinical factors between the NAFLD group and the control group. Individual prevalence of NAFLD at 1 month, 6 months and 1 year after surgery was 12%, 21% and 15%. Significantly different factors by univariate analysis were as follows: 1 month: age, sex, total protein (TP), total cholesterol (TC) and copper (Cu); 6 months: sex, disease, surgical method, portal vein resection (PVR), frequency of defecation, TC and Cu; 1 year: age, sex, disease, surgical method, PVR, frequency of defecation, TP and Cu. Risk factors by multivariate analysis were as follows: 1 month: not elderly age, female sex and a decrease in Cu; 6 months: female sex and a decrease in Cu; 1 year: a decrease in Cu. NAFLD after PD frequently developed in women with a decrease in serum Cu and was influenced by various factors related to poor digestion and absorption associated with pancreatic exocrine insufficiency.

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Noninvasive in vivo quantitative assessment of fat content in human liver

Cited by 286 publications

References 12 publications

Nonalcoholic fatty liver disease: a challenge for pediatricians

Nonalcoholic fatty liver disease: a challenge for pediatricians

Relationship between the Serum Concentrations of C-reactive Protein and Parameters of Adiposity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy

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