2012
DOI: 10.1073/pnas.1211659110
|View full text |Cite
|
Sign up to set email alerts
|

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function

Abstract: The autonomic nervous system is thought to modulate blood glucose homeostasis by regulating endocrine cell activity in the pancreatic islets of Langerhans. The role of islet innervation, however, has remained elusive because the direct effects of autonomic nervous input on islet cell physiology cannot be studied in the pancreas. Here, we used an in vivo model to study the role of islet nervous input in glucose homeostasis. We transplanted islets into the anterior chamber of the eye and found that islet grafts … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
115
0
2

Year Published

2014
2014
2024
2024

Publication Types

Select...
4
2
1

Relationship

1
6

Authors

Journals

citations
Cited by 104 publications
(123 citation statements)
references
References 50 publications
3
115
0
2
Order By: Relevance
“…Islet isolation, transplantation into the anterior chamber of the mouse eye, and in vivo islet imaging were performed as previously described (17,31). Blood vessels were labeled by tail vein injection of 150,000 Da Dextran-FITC.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…Islet isolation, transplantation into the anterior chamber of the mouse eye, and in vivo islet imaging were performed as previously described (17,31). Blood vessels were labeled by tail vein injection of 150,000 Da Dextran-FITC.…”
Section: Methodsmentioning
confidence: 99%
“…strategy in which islets are transplanted into the anterior chamber of the mouse eye. Transplanted islets have been shown to engraft on the iris, reverse diabetes, and regulate glucose homeostasis in the recipient mice (17,30,31). We transplanted 200 islets from young (2 mo) and aged (18 mo) mice into the eye of young mice with diabetes (2 mo; Fig.…”
Section: Aged Islet Grafts Functionally Recover In Young Recipient MImentioning
confidence: 99%
See 2 more Smart Citations
“…The transplanted islets in the eye (intraocular islets) have been used as optically accessible reporters of the endogenous islets, because they have similar structural and functional features as those in the native pancreas (Ilegems et al, 2013;Rodriguez-Diaz et al, 2012;Speier et al, 2008a). Despite several of its excellent utilities, the most essential application -the ability to repeatedly measure an islet's response to glucose stimulation in real time -has yet to be established.…”
Section: Introductionmentioning
confidence: 99%