Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography

Tawakol, Ahmed; Migrino, Raymond Q.; Hoffmann, Udo; Abbara, Suhny; Houser, Stuart L.; Gewirtz, Henry; Muller, James E.; Brady, Thomas J.; Fischman, Alan J.

doi:10.1016/j.nuclcard.2005.03.002

Cited by 262 publications

(185 citation statements)

References 44 publications

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“…[29], uptake has been shown to strongly correlate (r = 0.81, P < 0.0001) with plaque macrophage content, and this has been confirmed by others [30][31][32]. After balloon aortic injury in New Zealand white rabbits, Tawakol et al [33] demonstrated again a very strong correlation (r = 0.93, P < 0.002) between FDG uptake into atherosclerotic regions and plaque macrophage content. FDG uptake was 19 times greater in the region of greatest plaque formation as compared to controls.…”

Section: Vascular Imaging With Fdg-petmentioning

confidence: 68%

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

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Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. Although angiography is established as the gold standard means of detecting coronary artery stenosis, it does not image the vessel wall itself, reporting only on its consequences such as luminal narrowing and obstruction. MRI and computed tomography provide more information about the plaque structure, but recently positron emission tomography (PET) imaging using [ 18 F]-fluorodeoxyglucose (FDG) has been advocated as a means of measuring arterial inflammation. This results from the ability of FDG-PET to highlight areas of high glucose metabolism, a feature of macrophages within atherosclerosis, particularly in high-risk plaques. It is suggested that the degree of FDG accumulation in the vessel wall reflects underlying inflammation levels and that tracking any changes in FDG uptake over time or with drug therapy might be a way of getting an early efficacy readout for novel anti-atherosclerotic drugs. Early reports also demonstrate that FDG uptake is correlated with the number of cardiovascular risk factors and possibly even the risk of future cardiovascular events. This review will outline the evidence base, shortcomings and emerging applications for FDG-PET in vascular imaging. Alternative PET tracers and other candidate imaging modalities for measuring vascular inflammation will also be discussed.

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Section: Vascular Imaging With Fdg-petmentioning

confidence: 68%

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

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“…Because the metabolic and apoptotic signals are large, it is likely that even small lesions will be visible [18]. For these reasons, Tc-labeled annexin A5, a SPECT tracer as a marker of ongoing apoptotic cell death, and 18 F-FDG, a PET tracer as a marker of inflammation, are being evaluated for detecting vulnerable atherosclerotic plaques [18][19][20][21][22][23]. It…”

Section: Introductionmentioning

confidence: 99%

Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice

Zhao

Kuge

Zhao

et al. 2007

Eur J Nucl Med Mol Imaging

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“…In murine experiments, a strong correlation between FDG uptake and gene expression of inflammatory molecular markers has been demonstrated (21). Building on these early findings, in rabbits, it has been shown that inflamed aortic lesions accumulate up to 20 times more FDG than non-inflamed arterial lesions, thereby enabling reliable noninvasive detection of inflamed loci within arterial wall with FDG-PET (20). From these studies, it becomes clear that the PET derived FDG signal can be reliably used as a beacon for arterial wall inflammation.…”

Section: Basis For Arterial Fluorine-2-deoxy-d-glucose (Fdg) Uptake Fmentioning

confidence: 94%

“…Several studies have established a strong correlation between arterial FDG uptake and macrophage content in a variety of animal models (18)(19)(20). In murine experiments, a strong correlation between FDG uptake and gene expression of inflammatory molecular markers has been demonstrated (21).…”

Section: Basis For Arterial Fluorine-2-deoxy-d-glucose (Fdg) Uptake Fmentioning

confidence: 98%

Role of molecular imaging with positron emission tomographic in aortic aneurysms

et al. 2017

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Aortic aneurysms (AA) are often asymptomatic before the occurrence of acute, potentially fatal complications including dissection and/or rupture. Beyond aortic size, the ability to assess aortic wall characteristics and processes contributing to aneurysm development may allow improved selection of patients who may benefit from prophylactic surgical intervention. Current risk stratification for aneurysms relies upon routine noninvasive imaging of aortic size without assessing the underlying pathophysiologic processes, including features such as inflammation, which may be associated with aneurysm development and progression. The use of molecular imaging modalities with positron emission tomographic (PET) scan allows characterization of aortic wall inflammatory activity. Elevated uptake of Fuorine-2-deoxy-D-glucose (FDG), a radiotracer with elevated avidity in highly-metabolic cells, has been correlated with the development and progression of both abdominal and thoracic AA in a number of animal models and clinical studies. Other novel PET radiotracers targeting matrix metalloproteinases (MMPs), mitochondrial translocator proteins (TSPO) and endothelial cell adhesion molecules are being investigated for clinical utility in identifying progression of disease in AA. By further defining the activation of molecular pathways in assessing aortic regions at risk for dilatation, this imaging modality can be integrated into future clinical decision-making models.

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Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography

Cited by 262 publications

References 44 publications

Vascular imaging with positron emission tomography

Vascular imaging with positron emission tomography

Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice

Role of molecular imaging with positron emission tomographic in aortic aneurysms

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