“…For example, tumor grade is associated with relative cerebral blood volume [32][33][34] ; volume transfer coefficient [35][36][37][38] ; apparent diffusion coefficient 39,40 ; and cerebral metabolite ratios, for example, the choline to N-acetylaspartate 33 and the choline to creatine ratios. 33,41 Also, relative cerebral blood volume, 34,[42][43][44][45][46][47][48] volume transfer coefficient, 35,49 apparent diffusion coefficient, 50-52 and metabolite ratios, for example, the choline to Nacetylaspartate ratio, 53 aid prediction of PFS. Moreover, 1 H-MR spectroscopy of 2-hydroxyglutarate enables the detection of IDH mutations.…”