Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features <scp>(NIFTP):</scp> Implications for the risk of malignancy <scp>(ROM)</scp> in the Bethesda System for Reporting Thyroid Cytopathology <scp>(TBSRTC)</scp>

Zhou, Haijun; Baloch, Zubair W.; Nayar, Ritu; Bizzarro, Tommaso; Fadda, Guido; Adhikari-Guragain, Deepti; Hatem, Joseph; Larocca, Luigi Maria; Samolczyk, Julia; Slade, Jamie Macagba; Rossi, Esther Diana

doi:10.1002/cncy.21926

Cited by 65 publications

(71 citation statements)

References 33 publications

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“…Patients with indeterminate nodules that undergo surgical resection often turn out to have benign thyroid nodules or only indolent neoplasms, including NIFTP. NIFTP includes cases of indeterminate FNA previously diagnosed on histopathology as FVPC . The discrimination between benign and malignant thyroid lesions often requires documentation of vascular and capsular invasion, which cannot be established by cytological evaluation alone.…”

Section: Molecular Profiling Of Thyroid Lesionsmentioning

confidence: 99%

“…Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (NE‐FVPTC) was recently reclassified as NIFTP . As shown in the second edition of the Bethesda thyroid system, this new terminology has decreased the ROM in most of the TBSRTC categories, most significantly in the indeterminate categories . Some studies have demonstrated that NIFTP can indeed be differentiated from PTC in cytological samples .…”

Section: Niftp and Molecular Testingmentioning

confidence: 99%

“…The presence of nuclear pseudoinclusions and papillary structures are more typical features of PTC, whereas a predominantly follicular pattern and less frequent nuclear elongations and grooves are more likely to be associated with NIFTP . According to published series, the majority of NIFTP nodules are frequently diagnosed in the categories of AUS/FLUS (31.2%), SFN/FN (26.6%), and SM (24.3%) . for which the best suggested treatment is lobectomy.…”

Section: Niftp and Molecular Testingmentioning

confidence: 99%

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Ancillary molecular testing of indeterminate thyroid nodules

Rossi

Larocca

Pantanowitz

2018

Cancer Cytopathology

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Cytological specimens from thyroid nodules are increasingly being adopted as the first available material for cost effectively managing patients in the era of personalized medicine. Cytology aspirates not only play a central role in providing accurate diagnoses, but are also being collected for ancillary molecular testing. Molecular analysis, including the evaluation of somatic mutations and other genomic alterations, has accordingly become well integrated in the cytological workup of thyroid lesions. Appropriately handled thyroid cytology preparations provide well-preserved and adequately cellular material with improved DNA/RNA quantity. The recent publication of the 2nd edition of The Bethesda System for Reporting Thyroid Cytopathology and the American Thyroid Association guidelines confirm the relevant role of molecular testing in the management of the different subcategories of indeterminate thyroid lesions. This review discusses the role of molecular testing for indeterminate thyroid nodules, including the recent introduction of the noninvasive, encapsulated follicular variant of papillary thyroid carcinoma (FVPTC), known also as noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP).

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Section: Molecular Profiling Of Thyroid Lesionsmentioning

confidence: 99%

Section: Niftp and Molecular Testingmentioning

confidence: 99%

Section: Niftp and Molecular Testingmentioning

confidence: 99%

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Ancillary molecular testing of indeterminate thyroid nodules

Rossi

Larocca

Pantanowitz

2018

Cancer Cytopathology

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“…The extent of all the changes related to the NIFTP reclassification apparently depends on the incidence of NIFTP in a certain population. Approximately, 30 studies have been conducted in America, Europe and Asia reporting variable incidence . Bychkov et al, in a meta‐analysis, documented an average worldwide prevalence rate of 9.1%, with a lower rate in Asian studies (1.6%) as compared with non‐Asian countries (13.3%) .…”

Section: Discussionmentioning

confidence: 99%

Noninvasive follicular neoplasm with papillary like nuclear features: A comprehensive analysis with a diagnostic algorithm

Rana

Shreyamsa

Ramakant

et al. 2019

Diagnostic Cytopathology

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Background Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) lacks the carcinoma label, avoiding aggressive therapy, physiological, social and financial impact of cancer diagnosis. Unfortunately, the preoperative diagnosis is still a challenge. Varied incidence of NIFTP has been document with limited data on preoperative cytological, radiological characteristics and the impact on risk of malignancy in each category of the Bethesda system of reporting thyroid cytopathology. Method Retrospective analysis of 20 NIFTPs with an attempt to provide a preoperative diagnostic algorithm based on the cytological and ultrasound features along with incidence and implication on risk of malignancy in various Bethesda categories with its impact on patient management. Result Incidence of NIFTP in our study was higher in comparison to that documented from other Asian countries. TIRADS 3 was the most common sonographic diagnosis. NIFTP was commonly preceded by indeterminate or benign Bethesda category. Major impact of excluding NIFTP form malignant category was seen on Bethesda categories II and IV with 20% and 27% reduction in risk of malignancy, respectively. Conclusion Retrospective analysis should not be confined only to follicular variant of papillary thyroid carcinoma but cases of follicular adenoma and adenomatous colloid nodule should always be included in review to ascertain the true incidence of NIFTP. NIFTPs are less likely to have malignant preoperative cytology. NIFTP shares major cytological and ultrasound features with follicular adenoma, adenomatous colloid nodule and minimally invasive follicular papillary carcinoma. When analyzed together, taking minor findings in consideration, can favor a diagnosis.

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“…less frequent than in adults. 10 Medullary, poorly differentiated and anaplastic thyroid cancer are very rare in childhood.…”

Section: Epidemiologymentioning

confidence: 99%

Differentiated thyroid cancer in childhood: a literature update

Karapanou

Tzanela

Vlassopoulou

et al. 2018

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Differentiated thyroid cancer in childhood is rare. Apart from family history, radiation exposure is a major risk factor. Although its clinical course is quite aggressive with higher rates of lymph node and pulmonary metastases as compared to adults, the final outcome tends to be favorable with mortality rates less than 2%. we herein review the clinical picture, genetic background response to treatment and recurrence rates of differentiated thyroid cancer in children and young adolescents are thoroughly reviewed and the main differences with adult differentiated thyroid cancer are highlighted.

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Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC)

Cited by 65 publications

References 33 publications

Ancillary molecular testing of indeterminate thyroid nodules

Ancillary molecular testing of indeterminate thyroid nodules

Noninvasive follicular neoplasm with papillary like nuclear features: A comprehensive analysis with a diagnostic algorithm

Differentiated thyroid cancer in childhood: a literature update

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