Noninvasive Doppler determination of cardiac output in man. Clinical validation.

Huntsman, Lee L.; Stewart, David G.; Barnes, Sarah; Ss, Franklin; Colocousis, J S; Hessel, Eugene A.

doi:10.1161/01.cir.67.3.593

Cited by 576 publications

(208 citation statements)

References 31 publications

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“…However, in the non-compensatory phase, fibrosis and stiffness of the myocardial interstitium were suppressed by BPS administration and diastolic function was maintained [3,24]. The changing point from the compensatory phase to the non-compensatory phase was determined by arterial stiffness induced by pressure overload or cardiac hypertrophy through coronary circulation failure [4,10]. BPS effectively suppresses myocardial degeneration and fibrosis in chronic heart failure by improvement of coronary circulation and an anticytokine effect.…”

Section: Discussionmentioning

confidence: 99%

Effect of Long-term Administration of a Prostacyclin Analogue (Beraprost Sodium) on Myocardial Fibrosis in Dahl Rats

Kaneshige

Saida

Tanaka

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. Beraprost sodium (BPS) is an orally active prostacyclin analogue. The effects of BPS on the heart, including coronary circulation improvement, myocardial and vascular protection and anti-fibrosis effect on myocardium interstitium, have previously been demonstrated. However, the effects of BPS on hemodynamics, cardiac function and myocardial contractility in patients in the hypertrophic phase have not been clarified. Therefore, in the present study, the effects of BPS under long-term administration were investigated using the hypertension model of salt-sensitive Dahl rats. Six-week-old Dahl rats were divided into three groups, an 8% high salt diet group treated with BPS (BPS group), an untreated 8% high salt diet group (HHF group) and an untreated 0.3% low salt diet group (Control group), and observations were conducted until 17 weeks of age. In the BPS and HHF groups, the survival rates after 11 weeks of high salt diet intake were 87.5% and 47.1%, respectively (p<0.05). At 17 weeks of age, the atrial systolic peak velocity/early diastolic peak velocity and heart weight index of the BPS group decreased significantly compared with the HHF group (p<0.05). The HHF group exhibited significantly more severe myocardial fibrosis mainly in the endocardial layer of the left and right ventricles compared with the BPS and Control groups (p<0.05). In the present study, long-term BPS administration preserved diastolic function and prevented myocardial interstitial fibrosis in the non-compensatory phase. The results of the present study suggest that BPS is effective for treatment of hypertensive cardiac hypertrophy. KEY WORDS: beraprost sodium, Dahl rat, echocardiography, hypertension, myocardial fibrosis.J. Vet. Med. Sci. 69(12): 1271-1276, 2007 Prostacyclin is found in all body tissues and body fluids and is the major metabolite of arachidonic acid in the vasculature [6,16]. It is a potent vasodilator that affects both systemic and pulmonary circulations. Prostacyclin also prevents vascular smooth muscle proliferation and inhibits platelet adhesion and aggregation [6]. These features make it a very attractive substance for treatment of various cardiovascular diseases [6,15,16,20]. Beraprost sodium (BPS) is an orally active prostacyclin analogue that was discovered and developed by Toray Industries in Japan [1,16]. In human medicine, long-term administration of BPS has been approved as a treatment for chronic arterial occlusion [16] and primary pulmonary hypertension [2,8,16]. In addition, oral administration of BPS can be used as a therapeutic treatment for secondary precapillary pulmonary hypertension [17], cerebral infarction [9,13], glomerulonephritis [12,28], diabetic nephropathy [29] and atherosclerotic vascular damage in coronary artery disease [23]. In heart failure with pressure overload, compensated concentric hypertrophy in the left ventricular progresses due to the increase in pressure after overload. As a result, then the interstitial fibrosis changes the myocardial structure [21,26,27]. In addition, th...

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Section: Discussionmentioning

confidence: 99%

Effect of Long-term Administration of a Prostacyclin Analogue (Beraprost Sodium) on Myocardial Fibrosis in Dahl Rats

Kaneshige

Saida

Tanaka

et al. 2007

The Journal of Veterinary Medical Science

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“…9,10 Initially, suprasternal transthoracic ultrasound/Doppler probes were used for determining CO but they were not widely adopted because probe position instability limited their use for repeated measures over extended periods of time. 11 Esophageal probes were recognized to have two significant advantages over suprasternal probes. The first was that the smooth muscle tone of the esophagus is a natural means of maintaining the probe in position for repeated measures.…”

Section: Conclusion : Le Do Est Un Appareil De Mesure Périopératoire mentioning

confidence: 99%

“…In the former case, significant error in the actual aortic diameter may occur as a result of biological variation and in both cases error may arise from changing states of hydration, stress, vasoactive medication use, or from application of an aortic crossclamp. 11,15,16 In an attempt to minimize this error, an echo-ED model that contains both a Doppler and ultrasound (M-mode) probe has been developed. 12 With the echo-ED, real-time measurements of V f and CSA a are made and continuously measured ABF is displayed.…”

Section: Conclusion : Le Do Est Un Appareil De Mesure Périopératoire mentioning

confidence: 99%

Utility of esophageal Doppler as a minimally invasive hemodynamic monitor: a review

Laupland

Bands

2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : The current bedside "gold standard" for cardiac output (CO) monitoring is thermodilution using a pulmonary artery catheter (PAC) but there is a number of risks associated with its use. The primary objective of this review was to evaluate the utility of esophageal Doppler (ED) as a minimally invasive monitor of CO. S So ou ur rc ce e: : Medline literature search from 1966 to 2001 with citation review for studies comparing ED to PAC thermodilution for CO in perioperative and critically ill patients. P Pr ri in nc ci ip pa al l f fi in nd di in ng gs s: : Twenty-five publications were identifed comparing ED and PAC measurement of CO in a broad range of patients. There was a good overall correlation between CO determined by ED and thermodilution (n = 18 studies, median R = 0.89, range 0.52 to 0.98) and minimal bias (n = 13, median -0.01, range 1.38 to 2 L·min -1 ). The precision of ED was only fair overall as assessed by limits of agreement. The ED technique was found to be responsive in detecting changes in thermodilution CO and was reliable demonstrating both low intra-and inter-observer variation. ED was reportedly easy to insert after minimal training and was safe, with no significant complications identified. C Co on nc cl lu us si io on n: : ED is a practical, reliable, and valid device for measuring CO in perioperative and critically ill patients. Further studies with larger numbers of patients are needed to determine if the limited precision observed is inherent to the technique, the diagnoses of patients studied, or the small sample sizes.

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“…An indwelling venous cannula (Abbocath, 18G) was inserted into a forearm vein under local anaesthesia (2% lignocaine) for blood collection. All measurements were non-invasive and have been previously described in detail Huntsman et al, 1983;Moneta et al, 1988;Qamar et al, 1986a;Whitney, 1953) except for PI, PBF and DSBF. Mean arterial blood pressure (MABP) was calculated from the formula, systolic BP + twice diastolic pressure divided by three.…”

Section: Methodsmentioning

confidence: 99%

The effect of captopril on the superior mesenteric artery and portal venous blood flow in normal man.

Ray‐Chaudhuri

Thomaides

Maule

et al. 1993

Brit J Clinical Pharma

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1. Measurements of superior mesenteric artery and portal venous blood flow were made non‐invasively along with systemic and other regional (cardiac index, forearm and cutaneous blood flow) vascular responses to acute ingestion of the ACE inhibitor captopril (50 mg) or placebo (50 mg vitamin C), in 12 healthy subjects while supine and during head‐up tilt. 2. After captopril, superior mesenteric artery and portal blood flow rose markedly with a reduction in superior mesenteric artery vascular resistance. Supine blood pressure was unchanged but cardiac index and forearm blood flow rose; during head‐up tilt, blood pressure fell in some subjects. 3. There was a rise in levels of plasma renin activity and a fall in levels of plasma angiotensin II after captopril. After placebo, there were no significant changes in splanchnic blood flow, systemic or other regional responses and in biochemical measurements, while supine. 4. Our studies indicate that captopril is a potent dilator of the splanchnic vascular bed and suggest that this action may contribute to its therapeutic effects. The studies indicate a role for angiotensin II in the control of this large vascular bed although other agents (bradykinin, prostacyclin) may contribute.

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Noninvasive Doppler determination of cardiac output in man. Clinical validation.

Cited by 576 publications

References 31 publications

Effect of Long-term Administration of a Prostacyclin Analogue (Beraprost Sodium) on Myocardial Fibrosis in Dahl Rats

Effect of Long-term Administration of a Prostacyclin Analogue (Beraprost Sodium) on Myocardial Fibrosis in Dahl Rats

Utility of esophageal Doppler as a minimally invasive hemodynamic monitor: a review

The effect of captopril on the superior mesenteric artery and portal venous blood flow in normal man.

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