Noninvasive Coronary Plaque Imaging

Noguchi, Teruo; Nakao, Kazuhiro; Asaumi, Yasuhide; Morita, Yoshiaki; Otsuka, Fumiyuki; Kataoka, Yasufumi; Hosoda, Hayato; Miura, Hiroyuki; Fukuda, Tsuyoshi; Yasuda, Satoshi

doi:10.5551/jat.rv17019

Cited by 20 publications

(13 citation statements)

References 81 publications

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“…Комплексное изображение, полученное при использовании оптической когерентной томографии, или молекулярная визуализация с использованием целевых индикаторов, позволяет анализировать морфологию бляшки, состав и степень воспаления. Использование визуализации в кардиологии может быть предложено для оценки фенотипа бляшек высокого риска [1,2]. Определение предшествующих белкам транскриптов является информативным показателем изменений при патологических процессах и позволяет оценить степень выраженности заболевания до возникновения его фенотипических проявлений.…”

Section: сибирский журнал клинической и экспериментальной медициныunclassified

Analysis of differential expression of lipid metabolism genes in atherosclerotic plaques in patients with coronary atherosclerosis

Shakhtshneider

Ivanoshchuk

Ragino

et al. 2022

SJCEM

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Aim. The goal of the study was to analyze the differential expression of lipid metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis.Material and Methods. The study was performed on the specimens of atherosclerotic plaques in 45–65-year-old patients with coronary atherosclerosis with stable exertional angina functional class II-IV without acute coronary syndrome. Coronary atherosclerosis was verified by coronary angiography. Atherosclerotic plaque tissue was sampled intraoperatively when indicated. Whole-genome sequencing of ribonucleic acid (RNA) was performed using the TruSeq RNA Sample Preparation Kit (Illumina, USA).Results. We analyzed the differences in the expression of 12 genes including LDLR, APOB, PCSK9, LDLRAP1, LIPA, STAP1, ABCA1, APOA1, APOE, LPL, SCARB1, and SREBF2 depending on the type of atherosclerotic plaques. The expression level of APOE gene was eight times higher in unstable atherosclerotic plaques of dystrophic-necrotic type (p < 0.0001). The expression levels of LDLR and APOB genes were eight times higher in stable atherosclerotic plaques (p < 0.0001). We did not find differences in the expression levels of the ABCG5, ABCG8, APOC3, CETP, CLPS, CYP7A1, and PNPLA5 genes.Conclusion. The study showed the differences in the activity of individual metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis. Obtained data may become the basis for the development of test systems aimed at predicting the development of atherosclerotic process and its complications.

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Section: сибирский журнал клинической и экспериментальной медициныunclassified

Analysis of differential expression of lipid metabolism genes in atherosclerotic plaques in patients with coronary atherosclerosis

Shakhtshneider

Ivanoshchuk

Ragino

et al. 2022

SJCEM

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“…2 They have been shown to be a better predictor of future cardiovascular events compared with traditional cardiovascular risk factors in the general population. 3 Coronary arterial remodelling describes changes of vessel size at the site of atherosclerotic lesions. 4 Positive remodelling (expansion) of early lesions maintains lumen size despite plaque accumulation.…”

Section: Low-attenuationmentioning

confidence: 99%

“… 2 They have been shown to be a better predictor of future cardiovascular events compared with traditional cardiovascular risk factors in the general population. 3 …”

Section: Introductionmentioning

confidence: 99%

High-risk coronary plaque in SLE: low-attenuation non-calcified coronary plaque and positive remodelling index

Stojan

Budoff

et al. 2020

Lupus Sci Med

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BackgroundPositive remodelling index and presence of low-attenuation non-calcified plaque (LANCP) are characteristic vessel changes in unstable coronary plaques. We sought to characterise these high-risk plaque features in patients with systemic lupus erythematosus (SLE) and to compare them with controls.MethodsA total of 72 patients who satisfied the SLICC classification criteria for SLE had coronary CT angiography (CCTA) studies, 30 of which had follow-up CCTA, as screening for occult coronary atherosclerotic disease in asymptomatic individuals. A total of 100 consecutive controls with no known history of lupus, heart disease or revascularisation who had two coronary CT angiograms at least 1 year apart were included in the study. These were asymptomatic patients referred by their primary physicians for screening of coronary artery disease and the screening interval was decided by the primary physicians. The methodology for image acquisition was identical.ResultsLANCP burden at baseline was significantly greater in patients with SLE compared with controls. LANCP volume was significantly greater in patients over 60 years of age (p<0.05) and in those with current prednisone dose >10 mg/day. LANCP burden remained stable over follow-up. There were no significant differences in remodelling index compared with controls.ConclusionThis is the first study describing high-risk CCTA features of coronary plaque in patients with SLE. Both LANCP and positive remodelling are common in SLE. These characteristic vessel changes may identify patients with SLE at increased risk of cardiovascular events and those in need for more frequent cardiac monitoring.

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“…Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of atherosclerosis burden and characterization of coronary phenotypes beyond luminal stenosis [21] . The differentiation of coronary atherosclerosis allows for identification of particularly high-risk phenotypes such as noncalcified and lipid-rich necrotic core burden [22] , [23] , [24] .…”

Section: Introductionmentioning

confidence: 99%

Abdominal subcutaneous adipose tissue negatively associates with subclinical coronary artery disease in men with psoriasis

Teklu

Zhou

Kapoor

et al. 2021

American Journal of Preventive Cardiology

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Objective Understand the relationship between abdominal subcutaneous adipose tissue (ASAT) and coronary atherosclerosis defined as noncalcified and lipid-rich necrotic core burden in psoriasis. Methods We performed a cross-sectional study of 232 participants (92 women) with psoriasis and without known cardiovascular disease. Participants underwent coronary computed tomography angiography to characterize coronary atherosclerosis burden and low dose abdominal computed tomography to quantify subcutaneous and visceral adipose tissue. Fat depot volumes were first adjusted for each participant's BMI (ASAT adjBMI ). Results In women, there was a positive correlation between ASAT adjBMI and systemic inflammation as assessed by hs-C-reactive protein (r=0.30; p=.004) and GlycA (r=0.29; p=.007) as well as total cholesterol (r=0.24; p=.02) and low-density lipoprotein cholesterol (r=0.22; p=.04). In men, ASAT adjBMI correlated with hs-C-reactive protein (r=0.18; p=.04) and insulin resistance (r=0.17; p=.04). In models fully adjusted for traditional cardiovascular risk factors, ASAT adjBMI negatively associated with noncalcified and lipid-rich necrotic core burden in men (β= -0.17; p=.03, β= -0.20; p=.03, respectively), but not women (β= -0.06; p=.57, β= 0.09; p=.49, respectively) with psoriasis. Conclusions For a given BMI, ASAT negatively associated with coronary atherosclerosis burden in male participants with psoriasis. The observed sex-specific effects warrant further study of ASAT in states of chronic inflammation.

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Noninvasive Coronary Plaque Imaging

Cited by 20 publications

References 81 publications

Analysis of differential expression of lipid metabolism genes in atherosclerotic plaques in patients with coronary atherosclerosis

Analysis of differential expression of lipid metabolism genes in atherosclerotic plaques in patients with coronary atherosclerosis

High-risk coronary plaque in SLE: low-attenuation non-calcified coronary plaque and positive remodelling index

Abdominal subcutaneous adipose tissue negatively associates with subclinical coronary artery disease in men with psoriasis

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