Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics

McCormick, Patrick W.; Stewart, Melville; Goetting, Mark G.; Dujovny, Manuel; Lewis, Gary D.; Ausman, James I.

doi:10.1097/00003246-199101000-00020

Cited by 304 publications

(91 citation statements)

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“…This ratio is expressed as a percentage value of rSO 2 . 12,13 It is used widely in patients undergoing various procedures, including neurosurgery and cardiac surgery, 14 -16 because it provides real-time information about the level of cerebral tissue oxygenation in a non-invasive way.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Gynaecological Laparoscopic Surgery on Cerebral Oxygenation

Lee

et al. 2006

J Int Med Res

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During gynaecological laparoscopic surgery, alterations in cerebral blood flow and intracranial pressure are frequently reported. These changes affect cerebral perfusion pressure and thus may affect cerebral oxygenation. In this prospective study, the effect of gynaecological laparoscopic surgery on cerebral oxygenation was examined by following the changes in regional cerebral oxygen saturation (rSO 2 ). Twenty-four female patients were enrolled. The mean rSO 2 was 65.5 ± 5.4% at baseline before surgery, 60.8 ± 5.6% when the patient was placed in the Trendelenburg position, 57.1 ± 9.3% after creation of pneumoperitoneum, and 64.0 ± 7.3% after the completion of surgery. During the period of pneumoperitoneum, rSO 2 fell below 50% in two hypercapnic patients. In comparison with baseline, rSO 2 declined significantly in the Trendelenburg position. The creation of pneumoperitoneum itself did not decrease the average rSO 2 value further unless the patients were hypercapnic.

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Section: Introductionmentioning

confidence: 99%

The Effect of Gynaecological Laparoscopic Surgery on Cerebral Oxygenation

Lee

et al. 2006

J Int Med Res

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“…One, at 3 cm, is assumed to interrogate mainly extracerebral tissue and the other, at 4 cm, is assumed to interrogate cortical and intracerebral structures. Subtraction of the first from the second is then assumed to represent only the intracranial compartment [18]. However, 4 cm may be an inadequate interoptode separation to exclude totally extracranial absorption [19,20] and it may be that the subtraction algorithm 2002, 57, pages 999-1006 .…”

Section: Discussionmentioning

confidence: 99%

A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 Near‐Infrared Spectrophotometers

Broadhead²,

et al. 2002

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SummaryIn this study cerebral oxygenation was measured using the NIRO 300 and the INVOS 5100 spectrophotometers in 10 healthy adult volunteers, exposed to varying degrees of hyperoxia and hypoxia. The results showed similar baseline values for tissue oxygenation index and regional cerebral oxygen saturation with mean (SD) values being 64.9% (5.1) and 62.3% (6.0), respectively. The overall bias was -2.1%, with the INVOS 5100 under-reading cerebral oxygenation compared to the NIRO 300, with limits of agreement of ±14.7%. Both monitors demonstrated similar changes in response to hyperoxia and hypocapnia (coefficient of variance for F I O 2 0.45 ¼ 10.0%, F I O 2 1.0 ¼ 10.1%, hypocapnia ¼ 14.5%). The reasons for the bias and variability may relate to differences in the methodological approaches of the two monitors. The correlation between the monitors in response to changes in cerebral oxygenation implies that they may be useful as trend monitors in clinical practice.

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“…The sending and receiving fiberoptics within the probe were connected to a four-wavelength near infrared spectrometer (NeMo Control Unit ® , NeMo Devices AG). The technique of NIRS has previously been described in detail [10,11]. Relative concentration changes of the chromophores oxyhemoglobin (Hboxy) and deoxyhemoglobin (Hbdeoxy) were measured in arbitrary units (a.u.)…”

Section: Multimodal Neuromonitoringmentioning

confidence: 99%

The Hemodynamic Response of Spreading Depolarization Observed by Near Infrared Spectroscopy After Aneurysmal Subarachnoid Hemorrhage

et al. 2015

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Background Electrocorticography (ECoG) in brain-injured patients allows to detect spreading depolarization, a potential mechanism of secondary ischemia. Here, we describe the relationship of spreading depolarization with changes in cerebral hemodynamics using a brain tissue probe applying near infrared spectroscopy (NIRS). Methods Simultaneous ECoG and NIRS monitoring was performed in a patient with severe aneurysmal subarach-noid hemorrhage. Changes in cerebral blood oxygenation and regional cerebral blood volume were studied before and after the occurrence of spreading depolarization. Cerebral blood flow measurements were performed daily using an indocyanine green dye dilution mode. Results Single events of spreading depolarizations demonstrated with transient hyperoxic responses and in-crease in cerebral blood volume. On the other hand, temporal clusters of recurrent spreading depolarizations were associated with prolonged hypoxic responses and decrease in cerebral blood volume. Cerebral blood flow measurements showed higher values before compared to after onset of spreading depolarization (33.7 ± 8.4 vs. 24.2 ± 4.5 ml/100 g/min). Conclusions The findings suggest that NIRS monitoring in the cerebral white matter might reflect the hemodynamic signature of spreading depolarization detected by ECoG recordings. This is of potential interest for the further de-velopment of both neuromonitoring methods. AbstractBackground Electrocorticography (ECoG) in brain-injured patients allows to detect spreading depolarization, a potential mechanism of secondary ischemia. Here, we describe the relationship of spreading depolarization with changes in cerebral hemodynamics using a brain tissue probe applying near infrared spectroscopy (NIRS). Methods Simultaneous ECoG and NIRS monitoring was performed in a patient with severe aneurysmal subarachnoid hemorrhage. Changes in cerebral blood oxygenation and regional cerebral blood volume were studied before and after the occurrence of spreading depolarization. Cerebral blood flow measurements were performed daily using an indocyanine green dye dilution mode. Results Single events of spreading depolarizations demonstrated with transient hyperoxic responses and in-crease in cerebral blood volume. On the other hand, temporal clusters of recurrent spreading depolarizations were associated with prolonged hypoxic responses and decrease in cerebral blood volume. Cerebral blood flow measurements showed higher values before compared to after onset of spreading depolarization (33.7 ± 8.4 vs. 24.2 ± 4.5 ml/100 g/min). Conclusions The findings suggest that NIRS monitoring in the cerebral white matter might reflect the hemodynamic signature of spreading depolarization detected by ECoG recordings. This is of potential interest for the further development of both neuromonitoring methods.

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Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics

Cited by 304 publications

References 0 publications

The Effect of Gynaecological Laparoscopic Surgery on Cerebral Oxygenation

The Effect of Gynaecological Laparoscopic Surgery on Cerebral Oxygenation

A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 Near‐Infrared Spectrophotometers

The Hemodynamic Response of Spreading Depolarization Observed by Near Infrared Spectroscopy After Aneurysmal Subarachnoid Hemorrhage

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