Noninvasive cerebral blood volume measurement during seizures using multichannel near infrared spectroscopic topography

Abstract

Near infrared spectroscopic topography (NIRS) is widely recognized as a noninvasive method to measure the regional cerebral blood volume (rCBV) dynamics coupled with neuronal activities. We analyzed the rCBV change in the early phase of epileptic seizures in 12 consecutive patients with medically intractable epilepsy. Seizure was induced by bemegride injection. We used eight-channel NIRS in nine cases and 24 channel in three cases. In all of the cases, rCBV increased rapidly after the seizure onset on the focus side. The increased rCBV was observed for about 30-60 s. The NIRS method can be applied to monitor the rCBV change continuously during seizures. Therefore, this method may be combined with ictal SPECT as one of the most reliable noninvasive methods of focus diagnosis.

Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy

“…They have employed the technique to study cerebral response to visual Ruben et al, 1997), auditory (Sakatani et al, 1999), and somatosensory Obrig et al, 1996) stimuli; other areas of investigation have included the motor system (Colier et al, 1999;Hirth et al, 1996;Kleinschmidt et al, 1996) and language (Sato et al, 1999). Still other researchers have addressed the prevention and treatment of seizures (Adelson et al, 1999;Sokol et al, 2000;Steinhoff et al, 1996;Watanabe et al, 2000) and psychiatric concerns such as depression (Eschweiler et al, 2000;Matsuo et al, 2000;Okada et al, 1996b), Alzheimer disease (Fallgatter et al, 1997;Hanlon et al, 1999;Hock et al, 1996), and schizophrenia (Fallgatter and Strik, 2000;Okada et al, 1994), as well as stroke rehabilitation (Chen et al, 2000;Nemoto et al, 2000;Saitou et al, 2000;Vernieri et al, 1999).…”

Funtional Near Infrared Spectroscopy Study of Language, Joint Attention and Motor Skills

“…The observance of bilateral dominance during Rest task is similar to the finding from previous fMRI study, performed by Salvador et al (Salvador et al, 2005) on 5 healthy subjects during resting state, where significant coherence and hence bilateral activation (no dominance) was observed in superior frontal gyrus dorsolateral and medial. The current NIRS brain activation observations are similar to past studies, demonstrating predominant left cortex activation over the right cortex during verbal fluency tasks (Sakatani et al, 1998;Watanabe et al, 2000). In addition, the activation of the anterior and pre-frontal cortex observed during the Word generation task is similar to past NIRS studies (Elfgren et al, 1998;Hermann et al, 2003;Hermann et al, 2006;Kubota et al, 2005;Matsuo et al, 2000;Sakatani et al, 1998), in terms of the increase in HbO and HbT, and decrease in HbR concentrations.…”

“…In addition, a few researchers have analyzed the cortical lateralization and dominance features of the brain in different populations, based on their application focus (e.g. schizophrenia, epilepsy) (Gallagher et al, 2008;Hermann et al, 2003;Kennan et al, 2002;Kubota et al, 2005;Noguchi et al, 2002;Watanabe et al, 2000;Watson et al, 2004) . All the language studies carried out so far using NIRS (Gallagher et al, 2008;Herrmann et al, 2003, Jayakar et al, 2005Kennan et al, 2002;Kubota et al, 2005;Kuwabara et al, 2006;Noguchi et al, 2002;Qaresima et al, 2002;Sakatani et al, 1998;Watanabe et al, 1998;Watson et al, 2004) have focused on the brain activity differences and/or cortical dominance.…”

“…Some of the many applications (sample references listed) of NIRS to neuroimaging include: (i) cerebral response to visual Meek et al, 1995;Ruben et al, 1997), auditory (Sakatani et al, 1998) and somatosensory stimuli (Franceschini et al, 2003); (ii) cerebral response to motor system (Colier et al, 1999;Hirth et al, 1996;Schwartz et al, 2005) and language (Sato et al, 1999); and (iii) prevention and treatment of seizures (Adelson et al, 1999;Sokol et al, 2000;Steinhoff et al, 2005;Watanabe et al, 2000) and psychiatric concerns such as depression (Eschweiler et al, 2000;Matsuo et al, 2000;Okada et al, 1996), Alzheimer disease (Fallgatter et al, 1997;Hanlon et al, 1999;Hock et al, 1996) and schizophrenia Okada et al, 2004), as well as stroke rehabilitation (Chen et al, 2000;Nemoto et al, 2000;Saitou et al, 2000;Vernieri et al, 1999); (iv) detection of brain ischemia (Kuebler et al, 1998;Patel et al, 1998), necrosis, and hemorrhage (Yodh et al, 2003). During my doctoral work, NIRS was implemented to investigate the neural basis of language, joint attention and planning and execution of motor skills in healthy adults, as described below in section 2.4.…”

Dynamic physiological modeling for functional diffuse optical tomography

“…Clinical and research applications of DOT arise due to its specificity to the physiologically relevant chromophores HbO and HbR. Potential clinical and research applications for DOT abound in brain injury (Vernieri et al, 1999;Chen et al, 2000;Nemoto et al, 2000;Saitou et al, 2000), neurological diseases (Hock et al, 1996;Fallgatter et al, 1997;Hanlon et al, 1999;Steinhoff et al, 1996;Adelson et al, 1999;Sokol et al, 2000;Watanabe et al, 2000), psychiatric disorders (Okada et al, 1996b;Eschweiler et al, 2000;Matsuo et al, 2000;Okada et al, 1994;Fallgatter and Strik, 2000) and in cognitive and behavioral neuroscience (Ruben et al, 1997;Sakatani et al, 1999;Franceschini et al, 2003;Colier et al, 1999;Sato et al, 1999). Other research areas for DOT include infant monitoring (Chen et al, 2002;Hintz et al, 2001;Meek et al, 1999;Baird et al, 2002;Pena et al, 2003;Taga et al, 2003) and breast cancer detection Shah et al, 2004;Dehghani et al, 2003;Srinivasan et al, 2003).…”