Noninvasive assessments of skin glycated proteins by fluorescence and Raman techniques in diabetics and nondiabetics

Paolillo, Fernanda Rossi; Mattos, Vicente Silva; Oliveira, André Orlandi de; Guimarães, Francisco Eduardo Gontijo; Bagnato, Vanderlei Salvador; Neto, Jarbas Caiado Castro

doi:10.1002/jbio.201800162

Cited by 25 publications

(14 citation statements)

References 36 publications

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“…However, this combination needs to be tested in future large clinical trials to prove that multimodal low‐cost portable optical devices may be more accurate than benchtop systems and dermoscopy analysis of trained experts. Furthermore, these low‐cost portable systems may be tested for their ability to analyse other diseases (eg to monitor diabetes 31,32 or kidney failure 60 ) and to detect neoplasia in other body locations.…”

Section: Discussionmentioning

confidence: 99%

“…To cover this urgent need in easy‐to‐use low‐cost RS devices for skin cancer screening, we previously developed a portable RS system with handheld Raman probe 30 . Such compact RS‐based systems were also utilized, for example, to analyse human skin in monitoring diabetes 31,32 . In contrast to in‐laboratory systems 19,29,33 with a high degree of detector cooling (from −60 to −120°C), the proposed device operates only at –15°C that significantly decreases the dimensions, weight and cost of the system.…”

Section: Introductionmentioning

confidence: 99%

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In vivo diagnosis of skin cancer with a portable Raman spectroscopic device

Bratchenko

Moryatov

et al. 2021

Experimental Dermatology

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In this study, we performed in vivo diagnosis of skin cancer based on implementation of a portable low‐cost spectroscopy setup combining analysis of Raman and autofluorescence spectra in the near‐infrared region (800–915 nm). We studied 617 cases of skin neoplasms (615 patients, 70 melanomas, 122 basal cell carcinomas, 12 squamous cell carcinomas and 413 benign tumors) in vivo with a portable setup. The studies considered the patients examined by GPs in local clinics and directed to a specialized Oncology Dispensary with suspected skin cancer. Each sample was histologically examined after excisional biopsy. The spectra were classified with a projection on latent structures and discriminant analysis. To check the classification models stability, a 10‐fold cross‐validation was performed. We obtained ROC AUCs of 0.75 (0.71–0.79; 95% CI), 0.69 (0.63–0.76; 95% CI) and 0.81 (0.74–0.87; 95% CI) for classification of a) malignant and benign tumors, b) melanomas and pigmented tumors and c) melanomas and seborrhoeic keratosis, respectively. The positive and negative predictive values ranged from 20% to 52% and from 73% to 99%, respectively. The biopsy ratio varied from 0.92:1 to 4.08:1 (at sensitivity levels from 90% to 99%). The accuracy of automatic analysis with the proposed system is higher than the accuracy of GPs and trainees, and is comparable or less to the accuracy of trained dermatologists. The proposed approach may be combined with other optical techniques of skin lesion analysis, such as dermoscopy‐ and spectroscopy‐based computer‐assisted diagnosis systems to increase accuracy of neoplasms classification.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo diagnosis of skin cancer with a portable Raman spectroscopic device

Bratchenko

Moryatov

et al. 2021

Experimental Dermatology

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“…The studies in the field of noninvasive assessment of AGE accumulation using Raman spectroscopy are of particular interest. In a study conducted by Paolillo et al, Raman and fluorescence techniques were simultaneously used [63]. In this study, the degradation of type I collagen and increased glycation was shown in diabetics and changes in the collagen hydration state was noted for diabetic and chronological aging groups, according to Raman spectroscopy data.…”

Section: Optical Approaches In Diagnosticsmentioning

confidence: 78%

“…Raman spectra of skin[63]. Reproduced with permission of John Wiley and Sons F I G U R E 1 1 Terahertz images of a typical member of the, A, control and, B, diabetic groups.…”

mentioning

confidence: 99%

Biophotonics methods for functional monitoring of complications of diabetes mellitus

Zharkikh

Dremin

Zherebtsov

et al. 2020

Journal of Biophotonics

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The prevalence of diabetes complications is a significant public health problem with a considerable economic cost. Thus, the timely diagnosis of complications and prevention of their development will contribute to increasing the length and quality of patient life, and reducing the economic costs of their treatment. This article aims to review the current state-of-the-art biophotonics technologies used to identify the complications of diabetes mellitus and assess the quality of their treatment. Additionally, these technologies assess the structural and functional properties of biological tissues, and they include capillaroscopy, laser Doppler flowmetry and hyperspectral imaging, laser speckle contrast imaging, diffuse reflectance spectroscopy and imaging, fluorescence spectroscopy and imaging, optical coherence tomography, optoacoustic imaging and confocal microscopy. Recent advances in the field of optical noninvasive diagnosis suggest a wider introduction of biophotonics technologies into clinical practice and, in particular, in diabetes care units.

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“…However, diagnostic imaging is not the only means to increase the sensitivity and specificity of the currently applied criteria. Another non-invasive examination method with no significant contraindications is fluorescence spectroscopy, which has been used in medical diagnostics for many years [6–9].…”

Section: Introductionmentioning

confidence: 99%

The rheumatoid hand in the light of fluorescence: a diagnostic technique of the future?

Żuchowski¹,

Waszczak-Jeka²,

Kudlicki³

et al. 2019

Reumatologia

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Fluorescence spectroscopy is usually applied in physics, chemistry and related sciences. However, in recent years we can observe a growing interest in fluorescence spectroscopy for medical diagnostics. Currently, it is beginning to be used in the monitoring of rheumatoid arthritis (RA) activity. As the knowledge on RA increases, growing importance is being placed on the evaluation of synovitis. Today, it is difficult to imagine contemporary rheumatology without ultrasound (US) and magnetic resonance imaging (MRI). However, it turns out that these are not the only methods allowing one to visualise subclinical lesions, particularly synovitis. Fluorescence optical imaging (FOI) is also useful for the evaluation of inflammatory lesions in the joints. In the future, FOI may become competitive with “traditional” imaging studies. It is characterised by low cost, short duration and similar sensitivity to US.

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Noninvasive assessments of skin glycated proteins by fluorescence and Raman techniques in diabetics and nondiabetics

Cited by 25 publications

References 36 publications

In vivo diagnosis of skin cancer with a portable Raman spectroscopic device

In vivo diagnosis of skin cancer with a portable Raman spectroscopic device

Biophotonics methods for functional monitoring of complications of diabetes mellitus

The rheumatoid hand in the light of fluorescence: a diagnostic technique of the future?

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