Noninvasive Assessment of Transstenotic Pressure Gradients in Porcine Renal Artery Stenoses by Using Vastly Undersampled Phase-Contrast MR Angiography

Bley, Thorsten Alexander; Johnson, Kevin M.; François, Christopher J.; Reeder, Scott B.; Schiebler, Mark L.; Landgraf, Benjamin R; Consigny, Daniel W.; Grist, Thomas M.; Wieben, Oliver

doi:10.1148/radiol.11101175

Cited by 53 publications

(38 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, multi-dimensional investigations of velocity and flow in restrictions associated with highvelocity jet streams have been reported in clinical data [32][33][34]. Volumetric 4D PC sequences also offer the possibility to track the position of a restriction over the cardiac cycle.…”

Section: An Alternative Non-invasive Methods For Blood Velocity Measurmentioning

confidence: 99%

Volumetric velocity measurements in restricted geometries using spiral sampling: a phantom study

Nilsson

Revstedt

Heiberg

et al. 2014

Magn Reson Mater Phy

View full text Add to dashboard Cite

Object:To evaluate the accuracy of maximum velocity measurements using volumetric phase contrast imaging with spiral readouts in a stenotic flow phantom. Materials and Methods:In a phantom model, maximum velocity, flow, pressure gradient and streamline visualizations were evaluated using volumetric phase contrast MRI with velocity encoding in one (extending on current clinical practice) and three directions (for characterization of the flow field) using spiral readouts.Results of maximum velocity and pressure drop were compared to CFD simulations (Computational Fluid Dynamics), as well as corresponding low-TE Cartesian data. Flow was compared to 2D throughplane PC upstream from the restriction. Results:Results obtained with 3D throughplane PC as well as 4D PC at shortest TE using spiral readout showed excellent agreements with the maximum velocity values obtained with CFD (<1% for both methods), while larger deviations were seen using Cartesian readouts (-2% and 13%, respectively).Peak pressure drop calculated from 3D throughplane PC and 4D PC spiral sequences was 14% and 13% overestimated compared to CFD. Conclusion:Identification of the maximum velocity location as well as accurate velocity quantification can be obtained in stenotic regions using short-TE spiral volumetric PC imaging.3

show abstract

Section: An Alternative Non-invasive Methods For Blood Velocity Measurmentioning

confidence: 99%

Volumetric velocity measurements in restricted geometries using spiral sampling: a phantom study

Nilsson

Revstedt

Heiberg

et al. 2014

Magn Reson Mater Phy

View full text Add to dashboard Cite

show abstract

“…A negative correlation has been identified between the concentration of omentin and the thickness of the intima-media complex in carotid arteries, their stiffness, BMI, waist circumference, systolic arterial pressure, fasting blood glucose level and the insulin resistance index HOMA-IR (homeostasis model assessment of insulin resistance). Consequently, omentin is closely linked to the metabolic syndrome and its deficiency plays a significant role in the development of atheromatosis in these patients [33][34][35]. Zhong et al have demonstrated lower plasma levels of omentin in patients with acute coronary syndrome (ACS) or stable angina pectoris than in the control group.…”

Section: Omentynamentioning

confidence: 99%

“…Stwierdzono negatywną korelację stężenia omentyny z grubością kompleksu intima-media tętnic szyjnych, ich sztywnością, BMI, obwodem talii, skurczowym ciśnieniem tętniczym, stężeniem glukozy na czczo oraz wskaź-nikiem insulinooporności HOMA-IR (homeostasis model assessment of insulin resistance). Dlatego też omentyna jest ściśle związana z ZM, a jej niedobór odgrywa znaczącą rolę w rozwoju miażdżycy u tych pacjentów [33][34][35]. Zhong i wsp.…”

Section: Omentynaunclassified

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

View full text Add to dashboard Cite

Psoriasis is a chronic skin disease characterized by systemic inflammation associated with an increased risk of metabolic and cardiovascular complications. A special role in maintaining systemic inflammation is attributed to obesity. Adipose tissue is an active endocrine organ which, through adipokine secretion, is involved in the regulation of many systemic metabolic pathways. Obesity increases the risk of developing type 2 diabetes mellitus, atherosclerosis, cardiovascular diseases and hypertension. The paper presents the characteristics of two relatively recently discovered and little known adipokines: omentin and vaspin. They are considered to have beneficial effects preventing the development of metabolic disorders associated with obesity. In addition, attention was given to their possible involvement in the pathogenesis of psoriasis and potential use as markers of disease severity and the risk of developing metabolic complications. stReszczenIe Łuszczyca jest przewlekłą chorobą skóry, w której ogólnoustrojowy stan zapalny wiąże się ze zwiększonym ryzykiem rozwoju powikłań metabolicznych i sercowo-naczyniowych. Szczególne znaczenie w podtrzymaniu stanu zapalnego w organizmie ma otyłość. Tkanka tłuszczo-wa jest aktywnym organem endokrynnym, który poprzez wydzielane adipokiny bierze udział w regulacji licznych szlaków metabolicznych ustroju. Otyłość zwiększa ryzyko rozwoju cukrzycy typu 2, miażdżycy, chorób sercowo-naczyniowych oraz nadciśnienia. W pracy przedstawiono charakterystykę stosunkowo nowo odkrytych i mało poznanych adipokin: omentyny i waspiny, którym przypisuje się korzystne działanie, chroniące przed rozwojem zaburzeń metabolicznych towarzyszących otyłości. Ponadto zwrócono uwagę na ich potencjalny udział w patogenezie łuszczycy oraz możliwość wykorzystania jako markerów nasilenia choroby oraz ryzyka rozwoju powikłań metabolicznych.

show abstract

“…While the results from the turbulence intensity mapping agreed well with reference values from computational fluid dynamics data, the accuracy of the MRI-based wall shear stress estimates was found to be very sensitive to different parameters, especially to spatial resolution, and wall shear stress values over 5 N/m 2 were not well resolved.…”

mentioning

confidence: 52%

Fast and Accurate 4D Flow MRI for Cardiovascular Blood Flow Assessment

Petersson¹

2013

View full text Add to dashboard Cite

The study of blood flow is essential in understanding the physiology and pathophysiology of the cardiovascular system. Small disturbances of the blood flow may over time evolve and contribute to cardiovascular pathology. While the blood flow in a healthy human appears to be predominately laminar, turbulent or transitional blood flow is thought to be involved in the pathogenesis of several cardiovascular diseases. Wall shear stress is the frictional force of blood on the vessel wall and has been linked to the pathogenesis of atherosclerosis and aneurysms. Despite the importance of hemodynamic factors, cardiovascular diagnostics largely relies on the indirect estimation of function based on morphological data.Time-resolved three-dimensional (3D) phase-contrast magnetic resonance imaging (MRI), often referred to as 4D flow MRI, is a versatile and non-invasive tool for cardiovascular blood flow assessment. The use of 4D flow MRI permits estimation of flow volumes, pressure losses, wall shear stress, turbulence intensity and many other unique hemodynamic parameters. However, 4D flow MRI suffers from long scan times, sometimes over 40 minutes. Furthermore, the accuracy of the many different 4D flow MRI-based applications and estimates have not been thoroughly examined.In this thesis, the accuracy of 4D flow MRI-based turbulence intensity mapping and wall shear stress estimation was investigated by using numerical simulations of MRI flow measurements. While the results from the turbulence intensity mapping agreed well with reference values from computational fluid dynamics data, the accuracy of the MRI-based wall shear stress estimates was found to be very sensitive to different parameters, especially to spatial resolution, and wall shear stress values over 5 N/m 2 were not well resolved.To reduce the scan time, a 4D flow MRI sequence using spiral k-space trajectories was implemented and validated in-vivo and in-vitro. The scan time of 4D flow MRI was reduced by more than two-fold compared to a conventional Cartesian acquisition already accelerated using SENSE factor 2, and the data quality was maintained. For a 4D flow scan of the human heart, the use of spiral k-space trajectories resulted in a scan time of around 13 min, compared to 30 min for the Cartesian acquisition. By combining parallel imaging and spiral trajectories, the total scan time of a 4D flow measurement of the entire heart may be further reduced. This scan time reduction may also be traded for higher spatial resolution.Numerical simulation of 4D flow MRI may act as an important tool for future optimization and validation of the spiral 4D flow sequence. The scan-time reductions offered by the spiral k-space trajectories can help to cut costs, save time, reduce discomfort for the patient as well as to decrease the risk for motion artifacts. These benefits may facilitate an expanded clinical and investigative use of 4D flow MRI, including larger patient research studies.v Populärvetenskaplig sammanfattningHjärt-och kärlsjukdom är fortfarande den ...

show abstract

Noninvasive Assessment of Transstenotic Pressure Gradients in Porcine Renal Artery Stenoses by Using Vastly Undersampled Phase-Contrast MR Angiography

Cited by 53 publications

References 26 publications

Volumetric velocity measurements in restricted geometries using spiral sampling: a phantom study

Volumetric velocity measurements in restricted geometries using spiral sampling: a phantom study

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Fast and Accurate 4D Flow MRI for Cardiovascular Blood Flow Assessment

Contact Info

Product

Resources

About