Noninvasive assessment of metabolic turnover during inflammation by in vivo deuterium magnetic resonance spectroscopy
Vera Flocke,
Sebastian Temme,
Pascal Bouvain
et al.
Abstract:BackgroundInflammation and metabolism exhibit a complex interplay, where inflammation influences metabolic pathways, and in turn, metabolism shapes the quality of immune responses. Here, glucose turnover is of special interest, as proinflammatory immune cells mainly utilize glycolysis to meet their energy needs. Noninvasive approaches to monitor both processes would help elucidate this interwoven relationship to identify new therapeutic targets and diagnostic opportunities.MethodsFor induction of defined infla… Show more
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