Noninvasive assessment of liver fibrosis in chronic hepatitis C virus patients compared to liver biopsy: the experience of tertiary level hospital in Serbia

Preveden, Tomislav; Vereš, Benjamin; Ruzic, Maja; Pete, Maria; Luzza, Francesco; Pellicano, Rinaldo; Abenavoli, Ludovico

doi:10.23736/s0026-4806.19.06109-3

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…In people with hemophilia, liver biopsy is almost always contraindicated from a cost-benefit assessment standpoint, which is why none of the patients in this study had undergone this invasive diagnostic procedure. 22,25 Even though the HCV infections started in early childhood, liver cirrhosis was observed in 21.8% of patients. With the IQR 30-35 years, we observed that the duration of infection is the most important factor in the development of ESLD, in conjunction with co-infection (HIV/HBV), male sex, diabetes, obesity, and alcohol abuse.…”

Section: Discussion the Prevalence Of Hcv Infection In Personsmentioning

confidence: 99%

“…Most studies reported a greater frequency of mixed genotypes of HCV in infected PwH due to recombined HCV genomes in the event of long-lasting infections. 22 , 23 This phenomenon could affect the rate of resistance-associated substitutions and the genotype 1a resistance to DAA treatment protocols. 24 We have to indicate that this low percentage of mixed genotypes in our cohort could primarily result from unavailable molecular detection methods.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Ruzic

Rajic

Fabri

et al. 2021

Mediterr J Hematol Infect Dis

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Background: Treating HCV in people with hemophilia not only prevents the development of ESLD and HCC, but it also greatly increases the quality of life for people living with hemophilia. There are many obstacles in reaching the WHO goal of globally eradicating HCV by the year 2030., mainly its scale, complexity and implementation. That is why many countries have implemented a micro-elimination strategy: a pragmatic elimination approach in populations with the most efficacy. The aim of this publication is to present the morbidity and mortality rates, the clinical course and treatment outcomes of chronic HCV infection in PWH, as well as to show an example of a successfully conducted HCV micro-elimination strategy among people with hemophilia in the Province of Vojvodina. Methods: A retrospective, single-center study, performed using medical documentation of all registered PWH in the Clinical center of Vojvodina from 1994. until 2020. It included 74 hemophilia patients, out of which 32 were patients with hemophilia and chronic HCV infection. Results: The mean age of HCV positive PWH was 42.3 years, with the duration of infection of 30-35 years. Co-infection with HIV was observed in 6.25% of cases. Furthermore, 18.75% of patients had spontaneous HCV elimination and 75% patients were treated with antiviral protocols. Cirrhosis developed in 21.87% with an incidence rate of 0.6 per 100 patient-years. After treatment with Pegylated IFN and ribavirin (RBV), 58.3% achieved SVR. Side effects of IFN-based therapy regiment were recorded in 20.8% of treated PWH. In 37.5% PWH, DAA protocols were administered, and these patients achieved SVR. HCV positive PWH have a statistically higher mortality rate than non-infected people with hemophilia. Among the HCV positive PWH, hemophilia-related deaths were 6.25%, and HCV-related deaths were 9.37%. Currently, in the Registry of PWH in Vojvodina, there are no patients with active HCV infection. Conclusion: The micro-elimination strategy in subpopulation of PWH was successfully implemented in the Province of Vojvodina in close collaborations of hematologist and infectious diseases specialist.

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Section: Discussion the Prevalence Of Hcv Infection In Personsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Ruzic

Rajic

Fabri

et al. 2021

Mediterr J Hematol Infect Dis

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“…With well-defined DAA protocols, where fibrosis degree no longer dictates treatment decisions, non-invasive markers are crucial in monitoring post-therapy outcomes for chronic hepatitis C patients. The role of serum markers, both in patients with CHC or CHB, extends to identifying individuals at risk of HCC and underlying liver diseases sustaining fibrogenesis, enabling early planning of diagnostic procedures and HCC surveillance (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Non-invasive Assessment of Liver Damage Degree in Patients with Viral Hepatitis: Is It Feasible and Acceptable?

Vračarić,

Dejanović,

Janjić

et al. 2024

Hepat Mon

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Background: Hepatitis C and B virus infections significantly contribute to global chronic liver disease mortality. Objectives: This study explores the role of serum markers (AST/ALT ratio, APRI Score, FIB-4 Score, and Forns index) in non-invasively assessing liver damage in patients with chronic hepatitis C and B. Methods: In this single-center, retrospective, observational study, we analyzed data from 327 patients to establish correlations between serological markers and fibrosis grade using Spearman's correlation. Receiver operator characteristic (ROC) analysis evaluated the ability of these markers to predict advanced fibrosis. Results: In hepatitis B and C cohorts, all markers show significant positive correlations with liver fibrosis (P < 0.001). FIB-4 and the Forns index exhibit moderate correlation (Spearman’s rho 0.48), while AST/ALT and APRI score show mild correlation (Spearman’s rho 0.21 and 0.31). In hepatitis C, the Forns index (0.814) and FIB-4 (0.80) outperform other markers. In hepatitis B, Forns (AUC = 0.73), APRI (AUC = 0.68), and FIB-4 (AUC = 0.68) demonstrate significant predictive ability. Conclusions: FIB-4 and the Forns index hold clinical significance as fibrosis biomarkers in the management of chronic viral hepatitis. FIB-4 is a universal marker, while the interpretation of the Forns index requires consideration of the etiology of chronic viral hepatitis.

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The early identification of alcohol use disorders and liver injury: proposal for a diagnostic algorithm

Testino¹,

Fagoonee²,

Caputo³

et al. 2021

Panminerva Med

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Noninvasive assessment of liver fibrosis in chronic hepatitis C virus patients compared to liver biopsy: the experience of tertiary level hospital in Serbia

Cited by 5 publications

References 29 publications

Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients With Hemophilia in the Northern Region of Serbia

Non-invasive Assessment of Liver Damage Degree in Patients with Viral Hepatitis: Is It Feasible and Acceptable?

The early identification of alcohol use disorders and liver injury: proposal for a diagnostic algorithm

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