Noninvasive assessment of left ventricular filling pressure after acute myocardial infarction: A prospective study of the relative prognostic utility of clinical assessment, echocardiography, and B-type natriuretic peptide

Kruszewski, Kirsten; Scott, Anne; Barclay, Justin L.; Small, Gary; Croal, Bernard; Møller, Jacob Eifer; Oh, Jae K.; Hillis, Graham S.

doi:10.1016/j.ahj.2009.10.032

Cited by 44 publications

(29 citation statements)

References 28 publications

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“…According to the previous studies, the levels of high-sensitivity C-reactive protein (hs-CRP), Troponin (TnT), brain natriuretic peptide (BNP), and NT-proBNP were elevated in patients with myocardial infarction or ACS [20,21]. Our team's near-term systematic review and meta-analysis suggested that increased CRP levels are affiliated with great risk of new-onset AF after AMI [22].…”

Section: Scandinavian Journal Of Clinical and Laboratory Investigationmentioning

confidence: 84%

Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Gao

Zeng

Liao

et al. 2016

Scandinavian Journal of Clinical and Laboratory Investigation

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Section: Scandinavian Journal Of Clinical and Laboratory Investigationmentioning

confidence: 84%

Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Gao

Zeng

Liao

et al. 2016

Scandinavian Journal of Clinical and Laboratory Investigation

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“…1,2 It is plausible that NT-BNP, TnT and hs-CRP would represent distinct pathophysiological pathways to develop new onset atrial fibrillation (AF) in patients with AMI. 3-7 We therefore examined the association of NT-pro-BNP, TnT and hs-CRP with new-onset AF in hospitalized AMI patients to potentially identify those patients at high risk of developing new-onset AF in the setting of an AMI.…”

mentioning

confidence: 99%

New-Onset Atrial Fibrillation After Acute Myocardial Infarction and Its Relation to Admission Biomarkers (from the TRIUMPH Registry)

Parashar

Kella

Reid

et al. 2013

The American Journal of Cardiology

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Atrial fibrillation (AF) is an independent predictor of mortality after acute myocardial infarction (AMI). We analyzed the relationship between biomarkers linked to myocardial stretch [NT-pro-brain natriuretic peptide (NT-proBNP)], myocardial damage [Troponin-T (TnT)] and inflammation [high-sensitivity C-reactive protein (hsCRP)] and new-onset AF during AMI to identify patients at high risk for AF. In a prospective multicenter registry of AMI patients from (TRIUMPH), we measured NT-proBNP, TnT, and hsCRP in patients without a history of AF (N=2370). New-onset AF was defined as AF that occurred during the index hospitalization. Hierarchical multivariable logistic regression models were used to determine the association of biomarkers with new-onset AF, after adjusting for other covariates. New-onset AF was documented in 114 AMI patients (4.8%; mean age 58 years; 32% women). For each 2-fold increase in NT-proBNP, there was an 18% increase in the rate of AF (OR 1.18 95% CI 1.03-1.35; p<0.02). Similarly, for every 2-fold increase in hs-CRP, there was a 15% increase in the rate of AF (OR 1.15 95% CI 1.02-1.30; p=0.02). TnT was not independently associated with new-onset AF (OR 0.96 95% CI 0.85-1.07; p=0.3). NT-proBNP and hs-CRP were independently associated with new in-hospital AF after MI, in both men and women, irrespective of race. Our study suggests that markers of myocardial stretch and inflammation, but not the amount of myocardial necrosis, are important determinants of AF in the setting of AMI.

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“…BNP has been well recognized as an independent predictor of LV remodeling and other adverse cardiovascular events following acute MI [24][25][26][27]. Additionally this marker has been associated with various diastolic function indices re lecting LV illing pressure and has been shown to give incremental prognostic information in the same setting [28]. Although theoretically BNP levels would normally have some association with LA volume, as both indices are considered surrogates of LV diastolic illing properties, convincing data in the literature are missing.…”

Section: Discussionmentioning

confidence: 95%

Left Atrial Remodeling is Associated with Left Ventricular Remodeling in Patients with Reperfused Acute Myocardial Infarction

Ce¹

2016

J Cardiol Cardiovasc Med

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Background: Left atrial volume (LAV) has been established as a sensitive marker of left ventricular (LV) diastolic function and as an independent predictor of mortality in patients with acute myocardial infarction (AMI). LA remodeling and its determinants in the setting of AMI have not been much studied. Methods:We studied 53 patients with anterior AMI and a relatively preserved LV systolic function, who underwent complete reperfusion and received guidelines guided antiremodeling drug management. LA and LV remodeling were assessed using 2D echocardiography at baseline and 6 months. LAV indexed for BSA (LAVi) was used as the index of LA size and further LA remodeling.Results: LAVi increased signifi cantly at 6 months compared to baseline [28.1 (23.0-34.5) vs 24.4 (19.5-31.6) ml/m2, p=0.002] following LV end diastolic-volume index change [56.8 (47.6-63.9) vs 49.5 (42.0-58.4) ml/ m2, p=0.0003]. Other standard LV diastolic function indices did not show any signifi cant change. Univariate analysis showed a strong positive correlation of LAVi change with BNP levels at discharge, LV mass index and LV volumes indices change, throughout the follow up period. Multivariate regression analysis revealed that BNP plasma levels was the most important independent predictor of LA remodeling (b-coef.=0.630, p=0.001).Conclusions: Despite current antiremodeling strategies in patients with AMI, LA remodeling is frequently asssociated with LV remodeling. Additionally LAVi change in the mid-term refl ects better than standard echocardiographic indices LV diastolic fi lling impairment.

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Noninvasive assessment of left ventricular filling pressure after acute myocardial infarction: A prospective study of the relative prognostic utility of clinical assessment, echocardiography, and B-type natriuretic peptide

Cited by 44 publications

References 28 publications

Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

New-Onset Atrial Fibrillation After Acute Myocardial Infarction and Its Relation to Admission Biomarkers (from the TRIUMPH Registry)

Left Atrial Remodeling is Associated with Left Ventricular Remodeling in Patients with Reperfused Acute Myocardial Infarction

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