Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies

Neurath, Markus F.; Vehling, Dirk; Schunk, K.; Holtmann, Martin; Brockmann, Holger; Helisch, Andreas; Orth, Thomas; Schreckenberger, M.; Galle, Peter R.; Bartenstein, Peter

doi:10.1111/j.1572-0241.2002.05836.x

Cited by 174 publications

(51 citation statements)

References 25 publications

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“…FDG-PET depicts cells with an enhanced glucose metabolism. Apart from its role in the evaluation of malignancies, the role of FDG-PET in the diagnosis of focal inflammation and infection has been studied in patients suffering from osteomyelitis [1–3], vasculitis [4–8], inflammatory bowel disease [9–11] and sarcoidosis [12, 13]. Moreover, recent studies have shown its usefulness as a diagnostic tool in patients with fever of unknown origin (FUO) where more than one third of the PET scans were considered helpful in reaching a final diagnosis [14–17].…”

Section: Introductionmentioning

confidence: 99%

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

et al. 2009

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PurposeTo assess the value of F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) combined with CT in critically ill patients suspected of having an infection.MethodsFDG-PET CT scans requested for evaluation of a suspected infection or inflammatory process in critically ill, mechanically ventilated patients were analyzed (blinded for the final clinical diagnosis) and compared with clinical follow-up.ResultsThirty-five FDG-PET/CT scans performed in 33 ICU patients (28 adults and 5 children), median age 58 years (range 1 month–72 years), were analyzed. Twenty-one FDG-PET/CT scans were true positive. Three FDG-PET/CT scans were considered false positive, in one case leading to additional diagnostic procedures (specificity 79%). Additionally, 11 true negatives were found (sensitivity 100%), leading to an overall accuracy of 91%.ConclusionsFDG-PET/CT scanning is of additional value in the evaluation of suspected infection in critically ill patients in whom conventional diagnostics did not lead to a diagnosis. Apart from the high accuracy, in this study it appeared that, in addition to conventional diagnostic techniques that were routinely performed, a normal FDG-PET/CT ruled out important infections requiring prolonged antibiotic therapy or drainage. Since sensitivity is lower in highly metabolic active tissues (e.g., endocarditis, meningitis), the FDG-PET/CT scan is not suited to detect infections in these tissues.

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Section: Introductionmentioning

confidence: 99%

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

et al. 2009

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“…SPECT tracers: Neurath et al[53] enrolled 59 patients with CD in a prospective study, in order to assess disease activity by FDG-PET, hydro-MRI, and immunoscintigraphy with anti-nonspecific cross-reacting antigen 95 antigranulocyte antibodies. Twelve patients with irritable bowel syndrome and 20 patients with gut cancer but without gut inflammation served as controls.…”

Section: Resultsmentioning

confidence: 99%

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Caobelli

Evangelista

Quartuccio

et al. 2016

WJR

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AIMTo present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease (IBD).METHODSA systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in English.RESULTSFifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography.CONCLUSIONTo date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

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“…Recent studies have indicated the potential of FDG-PET to assess CD activity [13–15], although to our knowledge, there is no report on its potential to assess CD-associated malignant tumors. We performed FDG-PET in four of our patients prior to surgery and the results were positive in two patients and negative in two [16].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of cancer associated with Crohn’s disease

et al. 2016

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PurposeWe examined the clinicopathological characteristics and prognosis of patients with cancer associated with Crohn’s disease (CD).MethodsThe subjects of this study were patients with cancer confirmed in a resected specimen of bowel, who were treated at our institution between September, 1974 and December, 2014.ResultsWe analyzed 34 patients (26 men, 8 women, median age at cancer diagnosis 43.5 years, duration of illness 18 years) and found that the number of those with CD complicated with cancer began to drastically increase after 2005. The site of onset of cancer was in an anorectal lesion in 24 (70.6 %) patients. In 17 (50 %) patients, the cancer was diagnosed before surgery; in 3 patients (8.8 %), it was based on pathological findings during surgery; and in 14 patients (41.2 %), it was based on postoperative pathological findings. Mucinous carcinoma was the dominant histological type, seen in 15 patients (44.1 %), while the special type of signet-ring cell carcinoma was found in 4 patients. The cumulative overall 5 year survival rate was 46.2 %.ConclusionIn this group of Japanese CD patients, an anorectal lesion was the most frequent site of origin of cancer. As cancer was diagnosed preoperatively in only 50 % of these patients, the overall prognosis was poor, with a cumulative 5 year survival rate of just 46.2 %.

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Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies

Abstract: FDG-PET appears to be a reliable noninvasive tool for simultaneous detection of inflamed areas in the small and large bowel of patients with CD. FDG-PET can be used to detect disease activity in the terminal ileum and colon of CD patients with high sensitivity and specificity.

Cited by 174 publications

References 25 publications

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Clinicopathological characteristics of cancer associated with Crohn’s disease

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