Noninvasive Assessment of Coronary Flow Reserve with Transthoracic Signal–Enhanced Doppler Echocardiography

Lambertz, Heinz; Tries, Hans Peter; Stein, Thorsten; Lethen, Harald

doi:10.1016/s0894-7317(99)70134-3

Cited by 93 publications

(73 citation statements)

References 23 publications

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“…The time required to complete a CFVR test in one artery is around 5-8 minutes depending on the investigators' experience. Pizzuto et al, 2001 revealed CFVR value for the LAD ranging from 2.90±0.58 to 3.050.81 in control group of patients with angiographically normal coronary arteries, and similar values for CFVR were found in <50% LAD in-stent restenosis (Lambertz et al, 1999;. Later, CFVR in angiographically normal LAD patients with remote CAD (presence of previous remote myocardial infarction and wall motion abnormalities) was determined also as preserved (Pizzuto et al, 2004).…”

Section: Cut-off Level For Normal and Pathologic Cfvr 421 Tte Calcumentioning

confidence: 64%

“…Rest coronary flow is preserved until severe narrowing occurs (>80%), but according to the experimental study in mice (Wikstrom et al, 2005), there is a close correlation between CFVR in the left coronary artery and coronary minimal lumen diameter of this vessel (r=0.87, p<0.005), and CFVR depends on the diameter % stenosis. In clinical studies, the degree of angiographic stenosis also is related to CFVR in both the LAD and RCA (Lambertz et al,1999;Pizzuto et al, 2001;Voci et al, , 2003Sicari et al, 2009). With insignificant LAD stenosis (<50%), CFVR in the LAD is normal (Lambertz et al, 1999;, equal to 2.60.6 in subjects with totally normal coronary arteries, 2.60.6 in subjects with LAD stenosis of 0-20% and 2.20.5 in subjects with LAD stenosis of 20-40% (Sicari et al, 2009).…”

Section: Cfvr In Moderate and Severe Coronary Artery Stenosismentioning

confidence: 99%

“…In clinical studies, the degree of angiographic stenosis also is related to CFVR in both the LAD and RCA (Lambertz et al,1999;Pizzuto et al, 2001;Voci et al, , 2003Sicari et al, 2009). With insignificant LAD stenosis (<50%), CFVR in the LAD is normal (Lambertz et al, 1999;, equal to 2.60.6 in subjects with totally normal coronary arteries, 2.60.6 in subjects with LAD stenosis of 0-20% and 2.20.5 in subjects with LAD stenosis of 20-40% (Sicari et al, 2009). In cases with moderate stenosis, overall group CFVR is intermediate (from 2.23± 0.20 to 2.330.32); and only in high-grade stenosis CFVR is low (from 1.120.49 to 1.64 ± 0.30).…”

Section: Cfvr In Moderate and Severe Coronary Artery Stenosismentioning

confidence: 99%

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Transthoracic Echocardiography in the Assessment of Coronary Arteries

Boshchenko¹,

Vrublevsky²,

Карпов³

2011

Coronary Angiography - Advances in Noninvasive Imaging Approach for Evaluation of Coronary Artery Disease

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Section: Cut-off Level For Normal and Pathologic Cfvr 421 Tte Calcumentioning

confidence: 64%

Section: Cfvr In Moderate and Severe Coronary Artery Stenosismentioning

confidence: 99%

Section: Cfvr In Moderate and Severe Coronary Artery Stenosismentioning

confidence: 99%

See 1 more Smart Citation

Transthoracic Echocardiography in the Assessment of Coronary Arteries

Boshchenko¹,

Vrublevsky²,

Карпов³

2011

Coronary Angiography - Advances in Noninvasive Imaging Approach for Evaluation of Coronary Artery Disease

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“…[13,14] Decreased CFR values (CFR < 2) reflect coronary ED and may be evidence of severe coronary artery disease. [13][14][15][16] There are several previous reports suggesting that CFR impairment is highly prevalent in patients on chronic HD. [15] To our knowledge, there has been no report investigating the CFR impairment in PD patients.…”

Section: Y Caliskan Et Almentioning

confidence: 99%

“…CFR ≥ 2.0 was considered normal. [15,16] Left ventricle mass was calculated from M-mode records taken on parasternal longaxis images according to Devereux's formula. [17] Examinations of the patients conformed to good medical and laboratory practices and the recommendations of the Declaration of Helsinki on Biomedical Research involving Human Subjects.…”

Section: Coronary Flow Measurementmentioning

confidence: 99%

Plasma Ghrelin Levels Are Associated with Coronary Microvascular and Endothelial Dysfunction in Peritoneal Dialysis Patients

et al. 2009

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Cardiovascular (CV) disease is the main cause of death in peritoneal dialysis (PD) patients, and endothelial dysfunction (ED)is an early sign of vascular pathology. Ghrelin, a gastric peptide with CV actions, has been shown to inhibit proatherogenic changes in experimental models. However, another peptide hormone, leptin, may mediate deleterious effects on the CV system. The aim of this study is to evaluate the relationship between plasma ghrelin and leptin levels, and their association with coronary microvascular and endothelial functions in PD patients. Twenty-four (14 females and 10 males; mean age 44 ± 12 yr) nondiabetic PD patients, between 18 and 70 years of age, were enrolled. In addition to demographic, clinical, and laboratory parameters, plasma concentrations of ghrelin and leptin were evaluated. Endothelial functions of the coronary arteries were determined by coronary flow reserve (CFR) measurement using transthoracic Doppler echocardiography (TTDE). A CFR value of < 2 was used as an evidence for ED. When the study group was divided according to CFR measurements as CFR < 2 and ≥ 2, there were no significant differences considering age, gender, etiology of renal disease, body mass index (BMI), duration of dialysis, PD modality, PD solution type, history of peritonitis, mean arterial pressure, ejection fraction, and biochemical parameters between the two subgroups. Plasma ghrelin levels (129.4 ± 82.1 pg/mL) in patients with CFR ≥ 2 were significantly higher than those in patients with CFR< 2 (63.3 ± 35.8 pg/mL) (p = 0.03). However, no significant differences in plasma leptin levels were found between these groups [31.39 ± 37.81 ng/mL vs. 63.95 ± 72.83 ng/mL (p = 0.28)]. No correlation existed between plasma ghrelin levels and age, BMI, duration of dialysis, mean arterial pressure, ejection fraction, plasma leptin levels, and biochemical parameters. Decreased plasma ghrelin levels may contribute to the development of atherosclerosis in PD patients by causing ED.

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Acute Effects of Smoking Light Cigarettes on Coronary Microvascular Functions

Çiftçi

Çalışkan

Güllü

et al. 2009

Clinical Cardiology

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Background: To date, there has been no study comparing the possible acute effects on coronary microvascular functions of smoking light cigarettes (those with low tar and nicotine yield) and regular cigarettes. Methods: Twenty healthy volunteers (8 women and 12 men; mean age, 25.8 ± 5.8 years) were included in a single-blind, open-label, cross-over study to compare the effects of smoking light cigarettes (containing 0.6 mg nicotine, 8 mg tar, 9 mg carbon monoxide) and smoking regular cigarettes (containing 0.9 mg nicotine, 12 mg tar, 12 mg carbon monoxide) on coronary flow reserve (CFR). For each participant, CFR values were measured at baseline, after smoking 2 regular or light cigarettes, and 15 days later after smoking 2 cigarettes of the other kind. Results: After smoking 2 cigarettes, CFR values declined from 2.8 ± 0.56 (baseline) to 2.31 ± 0.51 after smoking light cigarettes (P = .003), and from 2.8 ± 0.56 (baseline) to 2.21 ± 0.45 after smoking regular cigarettes (P < .001). After smoking light and regular cigarettes, CFR values were similar (P = .678). Conclusions: Light cigarette smoking has similar acute detrimental effects on coronary microvascular function and CFR as does regular cigarette smoking.

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Noninvasive Assessment of Coronary Flow Reserve with Transthoracic Signal–Enhanced Doppler Echocardiography

Cited by 93 publications

References 23 publications

Transthoracic Echocardiography in the Assessment of Coronary Arteries

Transthoracic Echocardiography in the Assessment of Coronary Arteries

Plasma Ghrelin Levels Are Associated with Coronary Microvascular and Endothelial Dysfunction in Peritoneal Dialysis Patients

Acute Effects of Smoking Light Cigarettes on Coronary Microvascular Functions

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