Noninvasive and Curative Radiation Therapy for Sebaceous Carcinoma of the Eyelid

Hata, Masaharu; Koike, Izumi; Omura, Motoko; Maegawa, Jiro; Ogino, Ichiro; Inoue, Tomio

doi:10.1016/j.ijrobp.2010.12.006

Cited by 49 publications

(37 citation statements)

References 32 publications

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“…Radiation therapy is used in medically inoperable patients; however, the optimal dosage has not been established. Some reports suggest that radiotherapy is useful in controlling microscopic disease, as an adjuvant therapy17. The clinical utility of sentinel node biopsy has not been established18.…”

Section: Discussionmentioning

confidence: 99%

Sebaceous Carcinoma of the Suprapubic Area in a Liver Transplant Recipient

et al. 2014

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Sebaceous carcinoma is a very rare and potentially aggressive carcinoma originating from the epithelial lining of the sebaceous gland. More than 70% of all cases are in the head and neck region, especially the periorbita; therefore, they are classified into ocular and extraocular sebaceous carcinoma. The reported risk factors are advanced age, male sex, previous irradiation, and genetic predisposition for Muir-Torre syndrome. The current case is of sebaceous carcinoma found in the suprapubic area of a 67-year-old male patient who had received liver transplantation 6 years before, and had been receiving oral tacrolimus. Examination of the gastrointestinal system did not reveal any other malignancies. Although nonmelanoma skin cancers may occur as a complication after liver transplantation, there have been no previous reports of sebaceous carcinoma after liver transplantation. Furthermore, the sebaceous carcinoma in this case occurred in an uncommon location. We report this case along with a review of the literature.

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Section: Discussionmentioning

confidence: 99%

Sebaceous Carcinoma of the Suprapubic Area in a Liver Transplant Recipient

et al. 2014

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“…reported combined chemotherapy of carboplatin and docetaxel for the patient who had multiple lung and lymph node metastases, which resulted in a 30% decrease in tumor size, but the efficacy of this regimen for sebaceous carcinoma has not yet been fully evaluated [21]. Radiotherapy for primary eyelid sebaceous carcinoma was described in several reports; however, there have been no reports describing radiotherapy for pulmonary metastatic eyelid sebaceous carcinoma [22,23]. Resection of pulmonary metastases in patients with sebaceous carcinoma is controversial.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of a solitary pulmonary metastasis from eyelid sebaceous carcinoma: report of a case

et al. 2014

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BackgroundOcular sebaceous carcinoma is an uncommon, aggressive ocular neoplasm with potential for regional and distant metastasis.Case presentationA 77-year-old woman was found to have a solitary pulmonary lesion 6 years after the initial treatment of sebaceous carcinoma of the eyelid. Video-assisted lung wedge resection of an undetermined pulmonary nodule was carried out successfully. Microscopically, the tumor showed foamy cytoplasm and atypical nuclei, consistent with metastasis of eyelid sebaceous carcinoma.ConclusionThis is the first case report of resected solitary pulmonary metastasis of eyelid sebaceous carcinoma. Pulmonary resection is a good option for the treatment and diagnosis of metastatic eyelid sebaceous carcinoma.

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“…Radiation as primary therapy for patients who are inoperable or refuse exenteration has shown surprisingly good results when the dose of radiation has been 50-60 Gy. In a series published by Hata [53], all 5 patients who got radiation as primary treatment, were alive after 5 years. Radiation might be underused in the Nordic countries as only 50% would consider postoperative radiation.…”

Section: Fig 4 Scanning For Regional Lymph Nodes or Metastatic Diseamentioning

confidence: 99%

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

et al. 2020

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Background: The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma. Methods: The treatment practices data was collected by a questionnaire with 37 questions to the Nordic oculoplastic surgeons and analyzed. A PubMed MEDLINE database search was done to gather data on the published treatment practices and recommendations. A working group that consisted of in minimum one senior consultant from each leading Nordic University Eye Hospital was assigned. A structured interactive method was used to establish the consensus. Results: Twenty-four doctors responded to the questionnaire. 23/24 (96%) of the respondents took a biopsy before surgery. Regional lymph node scanning was routinely done by 14/23 (61%) and a systemic screening of a metastatic disease by 13/23 (57%). 6/22 (27%) never took conjunctival mapping biopsies and 12/23 (52%) never screened for Muir-Torre. Respondents used Mohs surgery, frozen section or multi-stage excision with delayed closure, and 5-6 mm was the mostly preferred margin. Sentinel lymph node biopsy was a possible option for 9/22 (41%) and cryotherapy and Mitomycin C for 6/22 (27%) respondents. 50% of respondents considered radiation as a treatment option. 15/16 (94%) respondents always followed-up their patients, most for 5 years. Two thirds scanned regional lymph nodes during the follow-up. Consensus was reached for 18 statements representing three domains: preoperative work-up, treatment and follow-up. Conclusion: Treatment practices differ in between the five Nordic countries which have similar public health care systems. In the article the authors present a Nordic consensus for the treatment of eyelid sebaceous carcinoma.

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Noninvasive and Curative Radiation Therapy for Sebaceous Carcinoma of the Eyelid

Cited by 49 publications

References 32 publications

Sebaceous Carcinoma of the Suprapubic Area in a Liver Transplant Recipient

Sebaceous Carcinoma of the Suprapubic Area in a Liver Transplant Recipient

Surgical treatment of a solitary pulmonary metastasis from eyelid sebaceous carcinoma: report of a case

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

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