Noninvasive Analysis of Lung Function in Small Animals: Compressed Air, Thoracic Gas Volume, Airway Resistance, Maximal Flow Rates, Tidal Volume, Breathing Frequency, l/E Ratio

Dorsch, Walter; Hess, Valentin

doi:10.1159/000236323

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…The results are given as the degree of "compressed' air. This technique has been shown to be about tenfold as sensitive as other invasive methods [3,4].…”

Section: Inhalation Challenge In Guinea Pigsmentioning

confidence: 98%

Acetophenones: Highly Active Antiasthmatic Compounds of Plant Origin

Dorsch¹,

Wagner²,

Neszmélyi³

et al. 1992

Int Arch Allergy Immunol

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In Ayurvedic medicine, Picrorrhiza kurroa Royle ex Benth. is used for the treatment of liver and lung diseases. We could identify the phenol glycoside, androsin, as an active compound preventing allergen- and PAF-induced bronchial obstruction in guinea pigs in vivo. The inhalation of androsin and its aglycon, apocynin, was more effective than the oral intake. More than 20 different acetophenones, either newly synthesized or purchased from commercial sources, have been tested in several pharmacological systems. 3,5-Dimethoxy-4-hydroxyacetophenone (Acetosyringenin) is by far the most active compound preventing allergen- and PAF-induced bronchial obstruction by more than 80% after one single dose of 0.5 mg (aerosol).

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“…The results are given as the degree of "compressed' air. This technique has been shown to be about tenfold as sensitive as other invasive methods [3,4].…”

Section: Inhalation Challenge In Guinea Pigsmentioning

confidence: 98%

Acetophenones: Highly Active Antiasthmatic Compounds of Plant Origin

Dorsch¹,

Wagner²,

Neszmélyi³

et al. 1992

Int Arch Allergy Immunol

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“…This very sensitve method measures the degree of bronchial obstruction and records not only the parameter 'compressed air', but also the airway resistance thorax gas volume, maximum flow rates, tidal volume, breathing frequency, and I/E (inspiration/expiration) ratio. The substances, or extract fractions under investigation, were applied either orally or as an aerosol to the guinea pigs sensitized to ovalbumin 1 h or 30 min prior to inhalation challenges with PAF (platelet activating factor) or ovalbumin (2).…”

Section: Screening For Antiasthmatic Plant Constituentsmentioning

confidence: 99%

Search for New Plant Constituents with Antiasthmatic and Antihypertonic Activity

Wagner¹

1998

ACS Symposium Series

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The development of target-directed in vitro screening methods (specific enzymes, primary cell cultures and receptors) has considerably stimulated the search for new potential drugs from plants. Inspite of the fact that the results obtained in vitro often have no counterpart in vivo and have to be confirmed in experimental animal studies, this new approach opens up the possibility of designing leading structures for the development of new drugs. This review summarizes results obtained in the author's research laboratory in recent years in an extensive program, which comprises the following areas: allergic asthma and cardiovascular diseases, in particular, high blood pressure. For the screening of isolated compounds and the monitoring of plant extract fractionations key enzymes and primary cell cultures of humans and animals as well as some in vivo models were used. The drugs for screening were selected primarily following ethnopharmacological guidelines. The results of structure-activity relationship studies are discussed with regard to their therapeutic relevance.Antiinflammatory drugs and those for the treatment of cardiovascular diseases rank second and third on the list of new drugs wanted for rational therapy, respectively. Although we possess a great number of powerful synthetic drugs we must confess that we do not have enough causally and rationally applicable drugs. In addition a great number of them have the handicap of causing severe adverse effects and being too toxic. In this context, it might also be worth stressing that from about 2000 registered human diseases and disorders, only about 40% can be cured. Bearing this in mind, it is essential to utilize the almost limitless resources provided by the plethora of potential medicinal plants of traditional medicine for an overall and thorough screening. However, only in a few exceptional cases will a screening program such as this result in a highly effective drug. Most of the new plant constituents found by a bioguided fractionation can be regarded as leading structures only, which may serve as starting templates for synthetic 46

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Antiasthmatic effects of gamma linolenic acid -high dose Evening Primrose Oil and Borage Oil stimulate allergen tachyphylaxis of sensitized guinea pigs and prevent allergen sensitization

Dorsch

Schmidt

1995

Phytomedicine

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Noninvasive Analysis of Lung Function in Small Animals: Compressed Air, Thoracic Gas Volume, Airway Resistance, Maximal Flow Rates, Tidal Volume, Breathing Frequency, l/E Ratio

Cited by 5 publications

References 2 publications

Acetophenones: Highly Active Antiasthmatic Compounds of Plant Origin

Acetophenones: Highly Active Antiasthmatic Compounds of Plant Origin

Search for New Plant Constituents with Antiasthmatic and Antihypertonic Activity

Antiasthmatic effects of gamma linolenic acid -high dose Evening Primrose Oil and Borage Oil stimulate allergen tachyphylaxis of sensitized guinea pigs and prevent allergen sensitization

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