Noninvasive acoustic manipulation of objects in a living body

Ghanem, Mohamed A.; Maxwell, Adam D.; Wang, Yak-Nam; Cunitz, Bryan W.; Khokhlova, Vera A.; Sapozhnikov, Oleg A.; Bailey, Michael R.

doi:10.1073/pnas.2001779117

Cited by 86 publications

(69 citation statements)

References 42 publications

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“…However, this structure is not suitable for an in vivo environment, because the configuration with opposed transducer pair cannot be used in patients depending on the treatment area. The traveling wave, by contrast, uses a phase pattern controlling for the particle trapping and manipulation without reflectors, thus transducers can be placed in the single-sided plane [ 23 , 24 , 25 ]. This traveling wave uses passive and active control of acoustic phase pattern.…”

Section: Introductionmentioning

confidence: 99%

Micromotor Manipulation Using Ultrasonic Active Traveling Waves

Cao

Jung²,

Lee

et al. 2021

Micromachines

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The ability to manipulate therapeutic agents in fluids is of interest to improve the efficiency of targeted drug delivery. Ultrasonic manipulation has great potential in the field of therapeutic applications as it can trap and manipulate micro-scale objects. Recently, several methods of ultrasonic manipulation have been studied through standing wave, traveling wave, and acoustic streaming. Among them, the traveling wave based ultrasonic manipulation is showing more advantage for in vivo environments. In this paper, we present a novel ultrasonic transducer (UT) array with a hemispherical arrangement that generates active traveling waves with phase modulation to manipulate a micromotor in water. The feasibility of the method could be demonstrated by in vitro and ex vivo experiments conducted using a UT array with 16 transducers operating at 1 MHz. The phase of each transducer was controlled independently for generating a twin trap and manipulation of a micromotor in 3D space. This study shows that the ultrasonic manipulation device using active traveling waves is a versatile tool that can be used for precise manipulation of a micromotor inserted in a human body and targeted for drug delivery.

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Section: Introductionmentioning

confidence: 99%

Micromotor Manipulation Using Ultrasonic Active Traveling Waves

Cao

Jung²,

Lee

et al. 2021

Micromachines

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“…Previous studies have proposed different acoustic tweezer configurations for noninvasively manipulating objects in a living body, such as single-beam acoustic tweezers and vortex beams (22,48). Compared with single-beam acoustic tweezers, the proposed AVT can trap micrometer-size particles via low-frequency ultrasound (3 MHz) because the trapping force relies on the generation of a potential well.…”

Section: Discussionmentioning

confidence: 99%

Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles

Fan

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Spatially concentrating and manipulating biotherapeutic agents within the circulatory system is a longstanding challenge in medical applications due to the high velocity of blood flow, which greatly limits drug leakage and retention of the drug in the targeted region. To circumvent the disadvantages of current methods for systemic drug delivery, we propose tornado-inspired acoustic vortex tweezer (AVT) that generates net forces for noninvasive intravascular trapping of lipid-shelled gaseous microbubbles (MBs). MBs are used in a diverse range of medical applications, including as ultrasound contrast agents, for permeabilizing vessels, and as drug/gene carriers. We demonstrate that AVT can be used to successfully trap MBs and increase their local concentration in both static and flow conditions. Furthermore, MBs signals within mouse capillaries could be locally improved 1.7-fold and the location of trapped MBs could still be manipulated during the initiation of AVT. The proposed AVT technique is a compact, easy-to-use, and biocompatible method that enables systemic drug administration with extremely low doses.

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“…With prospects of homogeneous actuation and surveillance, US imaging (MHz-GHz range) offers a suitable alternative for tracking micro- and nano-agents. The transducer arrays in BAW tweezers can be combined with commercially available US imaging probes for synchronized actuation and imaging of agents in biological tissues [137]. We envision the next generation of BAW devices to inherit features of US probes in order to transmit steerable acoustic beams inside the human body.…”

Section: Future Considerations On Emerging Technologiesmentioning

confidence: 99%

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

2020

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Acoustic actuation techniques offer a promising tool for contactless manipulation of both synthetic and biological micro/nano agents that encompass different length scales. The traditional usage of sound waves has steadily progressed from mid-air manipulation of salt grains to sophisticated techniques that employ nanoparticle flow in microfluidic networks. State-of-the-art in microfabrication and instrumentation have further expanded the outreach of these actuation techniques to autonomous propulsion of micro-agents. In this review article, we provide a universal perspective of the known acoustic micromanipulation technologies in terms of their applications and governing physics. Hereby, we survey these technologies and classify them with regards to passive and active manipulation of agents. These manipulation methods account for both intelligent devices adept at dexterous non-contact handling of micro-agents, and acoustically induced mechanisms for self-propulsion of micro-robots. Moreover, owing to the clinical compliance of ultrasound, we provide future considerations of acoustic manipulation techniques to be fruitfully employed in biological applications that range from label-free drug testing to minimally invasive clinical interventions.

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Noninvasive acoustic manipulation of objects in a living body

Cited by 86 publications

References 42 publications

Micromotor Manipulation Using Ultrasonic Active Traveling Waves

Micromotor Manipulation Using Ultrasonic Active Traveling Waves

Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

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