Noninterventional Therapies for the Management of Knee Osteoarthritis

Dadabo, Joseph; Fram, Julia; Jayabalan, Prakash

doi:10.1055/s-0038-1676107

Cited by 20 publications

(17 citation statements)

References 100 publications

(107 reference statements)

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“…The main results of this study supported the main findings of the previous two systematic reviews. 1,16 Zhang et al 1 suggest that pulsed and continuous therapeutic ultrasound in favor of pain relief may improve the physical function of patients with knee osteoarthritis. Dadabo et al 16 reported that therapeutic ultrasound must be applied often in patients with knee osteoarthritis in conjunction with traditional exercise programs targeting pain relief, improvements in physical function, stability, quadriceps strengthening and general cardiovascular fitness.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of continuous and pulsed therapeutic ultrasound combined with exercises for knee osteoarthritis: a randomized controlled trial

2020

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Objectives: To compare the effects of continuous and pulsed therapeutic ultrasound combined with strengthening exercises. Design: This is a double-blind randomized controlled trial. Setting: Pontifical Catholic University. Subjects: One hundred participants with Grade 2–4 knee osteoarthritis and both genders were involved. Intervention: Participants were randomized into five groups: Group I ( n = 20; in the first month, continuous ultrasound was applied), Group II ( n = 20; in the first month, pulsed ultrasound was applied), Group III ( n = 20; in the first and second months, continuous ultrasound was applied), Group IV ( n = 20; in the first and second months, pulsed ultrasound was applied) and Group V ( n = 20; patients received only exercise sessions for eight weeks). All patients in the groups that received ultrasound application performed exercises in the second month of treatment. The sessions occurred three times a week. Main measures: Pain was assessed using the visual analogical scale, functionality was assessed using the Lequesne questionnaire, range of motion was assessed using a universal goniometer, muscular strength was assessed using a dynamometer, mobility was assessed using the Timed Up and Go test and 8-meter walk test and the activity level was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. Results: Statistically significant differences ( P < 0.05) were presented by Group III in the variables pain during activities of daily living (ADLs) 5.89 (2.18), mobility assessed by 8-meter test 2.68 (2.56), in pain 10.65 (4.40), function 25.50 (10.87) and total 38.65 (15.29) of WOMAC and functionality 9.10 (5.15). Conclusion: Prolonged applications of continuous ultrasound combined with exercises are effective in providing pain, mobility, functionality and activity in subjects with knee osteoarthritis.

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Section: Discussionmentioning

confidence: 99%

Efficacy of continuous and pulsed therapeutic ultrasound combined with exercises for knee osteoarthritis: a randomized controlled trial

2020

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“…100 Acupuncture, therapeutic ultrasound and manual manipulation seem to exert moderate pain reduction especially in osteoarthritis; topical diclofenac or ketoprophen gel and capsaicin (by reducing nociceptive pain signals to the central nervous system) have shown relative efficacy in several placebo-controlled trials. 101 A number of medicinal plants such as Arnica montana, Boswella serrata, Curcuma longa and Harpagophytum procumbens have been shown to significantly improve pain and functionality in subjects with knee and hip osteoarthritis. 102 Upgrade of treatment to weak opioids (tramadol and codeine) alone or in combination with acetaminophen or even more powerful opioids such as fentanyl or hydrocodone may be an effective option although risk of addiction has become a worldwide problem in western countries.…”

Section: Pharmacological and Non-pharmacological Alternative Therapiementioning

confidence: 99%

Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice

Cabassi

Tedeschi

Perlini

et al. 2019

Eur J Prev Cardiolog

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Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposition to a polypharmacy burden represents a favourable substrate for the onset of non-steroidal anti-inflammatory drug-induced deleterious effects. Cardiovascular and renal issues concerning the occurrence of myocardial infarction, atrial fibrillation, heart failure and arterial hypertension, as well as acute or chronic kidney damage, become critical for clinicians in their daily practice. We discuss current available knowledge regarding prostanoid physiology in vascular, cardiac and renal systems, pointing out potential negative non-steroidal anti-inflammatory drug-related issues in clinical practice.

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“…Exercise therapy, which is defined as a regimen or plan of physical activities designed and prescribed for specific therapeutic goals, has currently been recommended as first-line treatment of OA (Roos and Juhl, 2012;Roos and Arden, 2016;Dadabo et al, 2019). Broadly, the goals of exercise therapy program are pain reduction and restoration of musculoskeletal function by strengthening muscle, improving joint stability, increasing range of motion, and improving aerobic fitness.…”

Section: Exercise Therapymentioning

confidence: 99%

Current Strategies for the Treatment of Early Stage Osteoarthritis

Zhang

2019

Front. Mech. Eng.

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Osteoarthritis (OA) is a leading cause of disability in elderly individuals. As a common chronic degenerative joint disease, OA is typically characterized by articular cartilage degeneration, subchondral bone sclerosis, and concomitant synovium inflammation. As such, the structural and functional alterations in the articular cartilage and subchondral bone become the focus of research during progression of OA. Similarly, the molecular mechanism regulating articular cartilage lubrication and the cellular communication controlling metabolic status of subchondral bone cells promote innovative strategies for prevention and treatment of early stage OA. The current therapeutic options for OA are aimed at keeping the associated pain, inflammation, and degeneration of synovial joint tissues manageable in order to minimize the structural and symptomatic progression. These include, but are not limited to, synergetic therapy combining lubrication and drug intervention, regulatory balance between bone resorption and formation, and exercise therapy. In this mini review, we focus on the up-to-date research progress on these novel strategies for OA treatment.

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Noninterventional Therapies for the Management of Knee Osteoarthritis

Cited by 20 publications

References 100 publications

Efficacy of continuous and pulsed therapeutic ultrasound combined with exercises for knee osteoarthritis: a randomized controlled trial

Efficacy of continuous and pulsed therapeutic ultrasound combined with exercises for knee osteoarthritis: a randomized controlled trial

Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice

Current Strategies for the Treatment of Early Stage Osteoarthritis

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