Noninherited maternal antigens do not play a role in rheumatoid arthritis susceptibility in europe

Barrera, Pilar; Balsa, Alejandro; Alves, Helena; Westhovens, René; Maenaut, K; Cornélis, François; Fritz, P; Bardin, Thomas; Almeida, GM; Lopes-Vaz, Antonio; Salcedo, Dora Pascual; Concha, Emilio G. de la; Radstake, Timothy R. D. J.; Putte, L. B. A. Van De; Migliorini, Paola; Prud’homme, Jean François; Charron, Dominique; Spyropoulou, M.; Mendes, Adélia; Spaepen, Marijke; Martı́nez, M.A.; Lepage, V.; Stravopoulos, C.

doi:10.1002/1529-0131(200004)43:4<758::aid-anr6>3.0.co;2-6

Cited by 17 publications

(7 citation statements)

References 29 publications

(28 reference statements)

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“…This observation was confirmed in one study (8), whereas, in two other studies (12,13), there was a nonsignificant trend in the same direction. When the studies were combined, a significant HLA-DR4 and SE NIMA effect in DR4 or SE-negative patients was observed (8).…”

mentioning

confidence: 59%

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development

Feitsma

Worthington

Mil

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA-region contributes most to the genetic risk. HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e., HLA-DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304) are associated with protection from RA. It has been proposed that not only inherited but also noninherited HLA-antigens from the mother (NIMA) can influence RA-susceptibility. Up to now, no protective NIMAs were described. Here, we studied whether DERAA-containing HLA-DRB1-alleles as NIMA are associated with a protective effect. One hundred seventy-nine families were studied, 88 from the Netherlands and 91 from the United Kingdom. The frequency of DERAA-containing HLA-DRB1-alleles of the Dutch mothers (16.1%), but not of the fathers (26.2%), was lower compared with the general Dutch population (29.3%; P ‫؍‬ 0.02). This was replicated in the English set of patients and controls (P ‫؍‬ 0.01). Further, of all families, 45 contained at least one DERAAnegative child with RA and at least one DERAA-positive parent. The odds for the DERAA-negative RA patients of having a DERAApositive mother was significantly lower compared with having a DERAA-positive father (OR 0.25; P ‫؍‬ 0.003). These data show a protective NIMA-effect in a human autoimmune disease and indicate that a DERAA-positive mother can transfer protection against RA to her DERAA-negative child.autoimmunity ͉ DERAA ͉ NIMA

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mentioning

confidence: 59%

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development

Feitsma

Worthington

Mil

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…Macrophages also support matrix remodeling and neoangiogenesis and have been implicated in conditions in which neoangiogenesis is potentially deleterious, including cancer (Qian and Pollard, 2010) but also non-neoplastic conditions, such as rheumatoid arthritis or endometriosis (Barrera et al, 2000; Bacci et al, 2009; Capobianco et al, 2010, 2011). All-together the data strongly support the ability of macrophages to perceive ongoing injury of various tissues, and to activate homeostatic programs that through the clearance of dying cells, the organization of neovessel generation, the regulation of the extracellular matrix remodeling and the activation of appropriate T lymphocyte responses leads to the effective healing.…”

Section: Macrophages: What’s In a Name?mentioning

confidence: 99%

Macrophages in Injured Skeletal Muscle: A Perpetuum Mobile Causing and Limiting Fibrosis, Prompting or Restricting Resolution and Regeneration

Bosurgi¹,

Manfredi²,

Rovere‐Querini³

2011

Front. Immun.

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Macrophages are present in regenerating skeletal muscles and participate in the repair process. This is due to a unique feature of macrophages, i.e., their ability to perceive signals heralding ongoing tissue injury and to broadcast the news to cells suited at regenerating the tissue such as stem and progenitor cells. Macrophages play a complex role in the skeletal muscle, probably conveying information on the pattern of healing which is appropriate to ensure an effective healing of the tissue, yielding novel functional fibers. Conversely, they are likely to be involved in limiting the efficacy of regeneration, with formation of fibrotic scars and fat replacement of the tissue when the original insult persists. In this review we consider the beneficial versus the detrimental actions of macrophages during the response to muscle injury, with attention to the available information on the molecular code macrophages rely on to guide, throughout the various phases of muscle healing, the function of conventional and unconventional stem cells. Decrypting this code would represent a major step forward toward the establishment of novel targeted therapies for muscle diseases.

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“…40 Studies since then have been divided and there is no clear consensus. [41][42][43] Combining all five reported data sets, an increased prevalence of DRB1*04-and SEpositive NIMA has been reported in SE-negative cases compared with the prevalence of DRB1*04-and SEpositive NIPA (odds ratio 2.1, P ¼ 0.003; odds ratio 2.0, P ¼ 0.04, respectively). 43 Marked heterogeneity between data sets was observed, and there is a clear need for sufficiently large study to address this question definitively.…”

Section: -30mentioning

confidence: 99%

A review of the MHC genetics of rheumatoid arthritis

et al. 2004

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Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.

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Noninherited maternal antigens do not play a role in rheumatoid arthritis susceptibility in europe

Abstract: Our results do not support the notion that noninherited maternal antigens have a role in susceptibility to RA in the offspring.

Cited by 17 publications

References 29 publications

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development

Macrophages in Injured Skeletal Muscle: A Perpetuum Mobile Causing and Limiting Fibrosis, Prompting or Restricting Resolution and Regeneration

A review of the MHC genetics of rheumatoid arthritis

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