Nonhuman Primates

Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition

“…The four fully mature female monkeys used for this study were of similar age (8,9,12, and 13 years). Archived ovaries from two premenopausal monkeys (8 and 13 y old) were used as additional untreated comparators.…”

“…Swelling and inflammation at the IM injection site was observed during VCD treatment (250 mg/kg), and although this resolved approximately 4 weeks after the final injection, a firm area of scar tissue in the muscle was still palpable 8 months later. All clinical health measures (hematologic and biochemical) remained within normal range (Bernacky et al [12]; Appt S.E., et al, unpublished data from control cynomolgus macaques assayed with the Ace-Alera analyzer at the CMCRC), except for a transient, mild increase in liver enzymes (AST Ϫ1.5 ϫ baseline, ALT -4 ϫ baseline) during treatment with 250 mg/kg, which resolved by day 15 of the VCD injections (Fig. 2).…”

Social status and helminth infections in female forest guenons (Cercopithecus mitis)

“…Infective larvae of Strongyloides penetrate the skin after contact with contaminated soil. Females produce eggs within two weeks of infection (Ashford and Barnish, 1989), and can be associated with cough, diarrhea, and hemorrhage (Eberhard, 1981;Bernacky et al, 2002;Sestak et al, 2003). Strongyloidiasis has been identified as a major nematode disease in nonhuman primates and has accounted for fatalities in captivity (Kuntz, 1982).…”

Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur (Lemur catta), China

“…In rare instances, however, it can infect nonhuman primates when, via accidental ingestion of infected arthropods, cysticercoids find their way into the small intestine. Nonhuman primates are thus a potential source of spread of the disease (Bernacky et al 2005) and are also pathogenic to humans (Hamlen and Lawrence 1994;Mario and Jeanette 2005;Miller et al 1990). To our knowledge, there have been no previous reports on H. nana infection in L. catta or its cure using mebendazole.…”