Nonhormonal drug use and its relation to androgens in perimenopausal women

Abstract

Hormone therapy in postmenopausal women seems to be associated with increased use of nonhormonal pharmacotherapy, rendering higher prevalence of such drugs in middle-aged women. Postmenopausal women with lower serum testosterone and a higher number of office visits used medications for cardiovascular problems and depression more than other medications. Whether this is an effect related to the hormone therapy itself or to experiencing more perimenopausal symptoms in this group of women is still unclear.

Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysis

“…E11 , E12 Two studies found no association between asthma medication use and HRT use. E39 , E47 Current use of HRT was associated with increased risk of current wheeze (OR, 1.40; 95% CI, 1.22-1.61), but not current allergic rhinitis (OR, 1.27; 95% CI, 0.97-1.68) ( Fig 2 ). Stratified analyses indicated increased risk of asthma onset in both nonoverweight/nonobese and overweight/obese women using HRT; however, HRT use was associated with current asthma, current wheeze, and current allergic rhinitis in nonoverweight/nonobese but not overweight/obese women ( Fig E4 ).…”

“…A total of 22,488 records were retrieved, of which 64 articles (reporting 57 studies) met the criteria to be included in the review. E5 , E10 , E11 , E12 , E13 , E14 , E15 , E16 , E17 , E18 , E19 , E20 , E21 , E22 , E23 , E24 , E25 , E26 , E27 , E28 , E29 , E30 , E31 , E32 , E33 , E34 , E35 , E36 , E37 , E38 , E39 , E40 , E41 , E42 , E43 , E44 , E45 , E46 , E47 , E48 , E49 , E50 , E51 , E52 , E53 , E54 , E55 , E56 , E57 , E58 , E59 , E60 , E61 , E62 , E63 , E64 , E65 , E66 , E67 , E68 , E69 , E70 , E71 , E72 In total, 554,293 participants were analyzed across the included studies. Of the 57 studies, 22 were included in at least ...…”

“…Of the 37 studies on endogenous hormones, 9 focused on puberty, E13 , E24 , E28 , E33 , E35 , E53 , E54 , E56 , E67 , E70 22 on menarche, E14 , E21 , E23 , E24 , E25 , E29 , E30 , E31 , E34 , E37 , E38 , E43 , E44 , E45 , E48 , E50 , E53 , E54 , E56 , E57 , E60 , E62 , E63 , E64 , E71 , E72 5 on menstruation, E22 , E25 , E30 , E43 , E44 , E45 , E66 and 11 on menopause. E15 , E17 , E27 , E32 , E36 , E39 , E40 , E42 , E43 , E44 , E45 , E62 , E63 , E64 , E68 , E69 Of the 31 studies on exogenous hormones, 17 focussed on hormonal contraceptives (15 observational E23 , E26 , E29 , E32 , E37 , E42 ...…”