Nonhealing venous ulcer in a patient with dystrophic soft tissue calcification

Nasif, Abdullah; Bauer, Karen; Pasadyn, Vanessa; Ahmed, Ayman; Nazzal, Munier; Osman, Mohamed

doi:10.1016/j.jvscit.2022.02.001

Cited by 2 publications

(1 citation statement)

References 11 publications

(22 reference statements)

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“…Compared to silicate bioactive glasses, some borate-based bioactive glasses degrade more quickly and completely due to their lower chemical durability. Also, despite fast conversion to CaP, borate bioactive glasses convert to hydroxyapatite (HA) more slowly than silicate glasses [ 11 ], which makes them more suitable for wound healing application, as the formation of HA layers on the surface of bioactive glass is undesirable in soft tissue repair [ 12 – 14 ]. Besides, the positive effects of boron on wound healing have been validated.…”

Section: Introductionmentioning

confidence: 99%

Cobalt-containing borate bioactive glass fibers for treatment of diabetic wound

Zhang,

Yao,

et al. 2023

J Mater Sci: Mater Med

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Impaired angiogenesis is one of the predominant reasons for non-healing diabetic wounds. Cobalt is well known for its capacity to induce angiogenesis by stabilizing hypoxia-inducible factor-1α (HIF-1α) and subsequently inducing the production of vascular endothelial growth factor (VEGF). In this study, Co-containing borate bioactive glasses and their derived fibers were fabricated by partially replacing CaO in 1393B3 borate glass with CoO. Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance (NMR) analyses were performed to characterize the effect of Co incorporation on the glass structure, and the results showed that the substitution promoted the transformation of [BO3] into [BO4] units, which endow the glass with higher chemical durability and lower reaction rate with the simulated body fluid (SBF), thereby achieving sustained and controlled Co2+ ion release. In vitro biological assays were performed to assess the angiogenic potential of the Co-containing borate glass fibers. It was found that the released Co2+ ion significantly enhanced the proliferation, migration and tube formation of the Human Umbilical Vein Endothelial Cells (HUVECs) by upregulating the expression of angiogenesis-related proteins such as HIF-1α and VEGF. Finally. In vivo results demonstrated that the Co-containing fibers accelerated full-thickness skin wound healing in streptozotocin (STZ)-induced diabetic rat model by promoting angiogenesis and re-epithelialization. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%