Nonhealing corneal ulcers in cats: 29 cases (1991–1999)

Croix, Noelle C. La; Woerdt, Alexandra van der; Olivero, Dennis K.

doi:10.2460/javma.2001.218.733

Cited by 49 publications

(67 citation statements)

References 2 publications

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“…The pathogenesis of corneal sequestrum is not understood. It is a widely accepted theory that corneal insult is an important initiating factor 14,15,26,36 . This was supported in this study by observations of breed‐related conformation, antecedent and concurrent ocular disease, and previous therapeutic interventions.…”

Section: Discussionsupporting

confidence: 83%

“…Chronic nonspecific ocular disease and specific causes of ocular irritation were present in more than half of cases. Procedures to stimulate corneal healing in indolent ulceration 36,47–49 and phenol cautery had been performed in 27% of cats. Such procedures represent a form of iatrogenic trauma to the cornea and appear to facilitate sequestrum formation 13,36 .…”

Section: Discussionmentioning

confidence: 99%

“…La Croix et al. 36 recently described that the iatrogenic corneal trauma associated with grid keratotomy for nonhealing ulcers may predispose to sequestrum formation. Cullen et al.…”

Section: Introductionmentioning

confidence: 99%

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Feline corneal sequestra: a review of 64 cases (80 eyes) from 1993 to 2000

Featherstone¹,

Sansom

2004

Veterinary Ophthalmology

150

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Feline corneal sequestrum is a common condition of the feline cornea. The purpose of this study was to provide a detailed description of the clinical features of the condition including the response to different management options and to assess the rate of recurrence. The medical records of 64 cases (80 eyes) of feline corneal sequestra that presented to the Animal Health Trust from 1993 to 2000 were reviewed. Fifty-two cases were reviewed retrospectively; 12 cases were assessed prospectively between April and September 2000 as part of a separate study. The Persian was the most frequently encountered breed and the mean age of affected cats was 5.6 years. At initial presentation, sequestra were unilateral in 58 cats and bilateral in 6 cats, 5 of which were Persians. Ocular discomfort and ocular discharge were common presenting signs, occurring in 42 and 36 eyes, respectively. Seventy-four eyes were managed surgically with keratectomy only (n = 44) or keratectomy followed by a graft procedure (n = 30). Sequestra recurred in 16 eyes in the study. There was no significant difference in the rate of recurrence between eyes that received a graft procedure (n = 5) and eyes that did not (n = 11) (P = 0.56). Complications following transection of conjunctival pedicle grafts were observed. Brown to black discoloration of noncorneal tissue and therapeutic biomaterials was observed, including discoloration of both viable and apparently nonviable grafted conjunctival tissue, small intestinal submucosa graft material and bandage contact lenses.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Feline corneal sequestra: a review of 64 cases (80 eyes) from 1993 to 2000

Featherstone¹,

Sansom

2004

Veterinary Ophthalmology

150

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“…Based on these findings, it was concluded that SCCED relates to inherent abnormalities in epithelial basement membrane structure, adhesion complexes and adjacent anterior stromal extracellular matrix. While similar disease manifestations have been observed in cats and horses, they are comparatively poorly described, and a common histopathological description has not been illustrated. The purpose of this retrospective study was to delineate the histopathological features of chronic, nonhealing, superficial, corneal ulcers in the equine species.…”

Section: Introductionmentioning

confidence: 90%

Histopathological features of equine superficial, nonhealing, corneal ulcers

Hempstead¹,

Clode

Borst

et al. 2013

Veterinary Ophthalmology

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The most consistent histopathological characteristics of equine chronic, nonhealing, superficial, corneal ulcers include epithelial nonadherence, epithelial dysmaturity and mild to moderate stromal inflammation; however, one set of histopathological characteristics does not definitively define this syndrome in horses. Additionally, the anterior stromal acellular hyaline zone commonly cited in canine spontaneous chronic corneal epithelial defects (SCCED) is not a consistent finding in equine corneas.

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“…Even today, the aetiology is unknown, although traumas, prolonged corneal irritation, alterations of the tear film and of the corneal innervation, dystrophy, infections (Herpesvirus) and genetic predisposition would appear to play an important role in determining its onset (Startup, 1988;Pentlarge, 1989;Morgan, 1994;Cullen et al, 1999;La Croix et al, 2000).…”

Section: Introductionmentioning

confidence: 97%