Nongenomic cortisol signaling in fish

Das, Chinmayee; Thraya, Marwa; Vijayan, Mathilakath M.

doi:10.1016/j.ygcen.2018.04.019

Cited by 54 publications

(22 citation statements)

References 66 publications

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“…In teleosts, cortisol is the primary glucocorticoid regulating a series of physiological processes, such as metabolism, immunity, and growth [45]. Besides, cortisol was reported a peaking expression during sex change in anemonefish [46] and promoted the masculinization in Pejerrey [47], which suggests a role in sex reversal.…”

Section: Discussionmentioning

confidence: 99%

Integration of ATAC-seq and RNA-seq Unravels Chromatin Accessibility during Sex Reversal in Orange-Spotted Grouper (Epinephelus coioides)

Yang

Zhong

et al. 2020

IJMS

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Chromatin structure plays a pivotal role in maintaining the precise regulation of gene expression. Accessible chromatin regions act as the binding sites of transcription factors (TFs) and cis-elements. Therefore, information from these open regions will enhance our understanding of the relationship between TF binding, chromatin status and the regulation of gene expression. We employed an assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and RNA-seq analyses in the gonads of protogynous hermaphroditic orange-spotted groupers during sex reversal to profile open chromatin regions and TF binding sites. We focused on several crucial TFs, including ZNF263, SPIB, and KLF9, and analyzed the networks of TF-target genes. We identified numerous transcripts exhibiting sex-preferred expression among their target genes, along with their associated open chromatin regions. We then investigated the expression patterns of sex-related genes as well as the mRNA localization of certain genes during sex reversal. We found a set of sex-related genes that—upon further study—might be identified as the sex-specific or cell-specific marker genes that trigger sex reversal. Moreover, we discovered the core genes (gnas, ccnb2, and cyp21a) of several pathways related to sex reversal that provide the guideposts for future study.

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Section: Discussionmentioning

confidence: 99%

Integration of ATAC-seq and RNA-seq Unravels Chromatin Accessibility during Sex Reversal in Orange-Spotted Grouper (Epinephelus coioides)

Yang

Zhong

et al. 2020

IJMS

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“…These results indicate that the influence of AA on thyroid activity remains uncertain, which may be related to animal species, animal health status, dietary composition and feeding environment. Cortisol is the primary glucocorticoid hormone in teleost and mediates a suite of physiological responses (Das, Thraya, & Vijayan, ). An elevation of serum cortisol is a commonly used indicator of stress in fish (Madaro, Folkedal, Maiolo, Alvanopoulou, & Olsen, ).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary ascorbic acid levels on cholesterol metabolism in rainbow trout (Oncorhynchus mykiss)

Deng

Zhang

et al. 2019

Aquacult Nutr

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An 80-day feeding trial was conducted to evaluate the effects of dietary ascorbic acid (AA) supplementation at different levels (0, 0.2 and 0.4 g/kg l-ascorbate-2-polyphosphate; 7.6, 77.2 and 146.7 mg/kg AA, respectively) on cholesterol metabolism in rainbow trout (Oncorhynchus mykiss). Dietary AA supplementation regardless of inclusion level increased the serum total cholesterol and low-density lipoprotein (LDL) cholesterol levels and LDL cholesterol/high-density lipoprotein cholesterol ratio. No significant differences were observed in the serum triiodothyronine and thyroxine levels, faecal cholesterol content, hepatic activity and mRNA expression of acyl-coenzyme A:cholesterol acyltransferase among the dietary treatments. Dietary AA inclusion increased the faecal bile acid content, hepatic activity and mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and hepatic cholesterol 7α-hydroxylase mRNA expression, but decreased the hepatic LDL receptor content.High level of AA supplementation (0.4 g/kg) depressed the serum cortisol levels.These results suggest that dietary supplementation with 0.2-0.4 g/kg l-ascorbate-2polyphosphate may increase the serum total cholesterol level in rainbow trout. The cholesterol-raising effect of AA may be due to the increased hepatic cholesterol production and the depressed cholesterol clearance from serum. In addition, dietary AA inclusion also facilitates the hepatic conversion of cholesterol to bile acids. K E Y W O R D Sascorbic acid, cholesterol, homeostasis, l-ascorbate-2-polyphosphate, metabolism, rainbow trout

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“…Altogether with the mineralocorticoid functioning of cortisol, that allow teleost fish to modify the osmoregulatory processes and acclimate to different environmental salinities [48], this hormone is also related to chronic stress responses [18]. In this sense, cortisol stimulates several aspects of intermediary metabolism and sustained high levels are interpreted as a signal of distress [49], regulating lipid metabolism and possibly promoting gluconeogenesis [50]. In this line, it was described that chronic stress situations, such as inadequate stocking densities, induced consumption of hepatic stores, increased glycolytic and glycogenolytic pathways, mobilized lipids and increased amino acid consumption in S. rhombus, D. cuneata, Rhamdia quelen, P. pagrus and E. maclovinus [51][52][53][54][55].…”

Section: Discussionmentioning

confidence: 99%

Narrowing the Range of Environmental Salinities Where Juvenile Meagre (Argyrosomus regius) Can Be Cultured Based on an Osmoregulatory Pilot Study

Ruíz-Jarabo

Marquez

Vargas‐Chacoff

et al. 2018

Fishes

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Aquaculture in Europe aims to diversify and optimize fish farming. The meagre (Argyrosomus regius) arose as a promising species due to its fast growth rates and flesh quality. Thus, it is currently being produced in several Mediterranean countries, mainly in sea-cages and salt-marshes. However, although meagre naturally spend the first years of life in brackish waters, to date it is cultured in seawater. Here, we show that juveniles may not successfully face either freshwater or hyper-osmotic environments as high as 55 ppt salinity. We found that 55 ppt induced catabolism and mobilization of energy metabolites stored in the liver, probably to maintain its osmotic balance. Furthermore, we found that osmoregulatory tissues such as gills managed to maintain plasma osmolality levels without differences in meagre acclimated at 5, 12 and 39 ppt salinity. Our results demonstrate the euryhaline capacity of this species, highlighting that juveniles may be cultured in a wider range of salinities rather than just at seawater. Future studies should focus on optimal environmental salinities for the growth of A. regius juveniles, including long-term experiments limited to the range of 5 ppt to full-strength seawater. Minimizing fish energy consumption in osmoregulation could be economically beneficial for the aquaculture industry in Europe.

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Nongenomic cortisol signaling in fish

Cited by 54 publications

References 66 publications

Integration of ATAC-seq and RNA-seq Unravels Chromatin Accessibility during Sex Reversal in Orange-Spotted Grouper (Epinephelus coioides)

Integration of ATAC-seq and RNA-seq Unravels Chromatin Accessibility during Sex Reversal in Orange-Spotted Grouper (Epinephelus coioides)

Effects of dietary ascorbic acid levels on cholesterol metabolism in rainbow trout (Oncorhynchus mykiss)

Narrowing the Range of Environmental Salinities Where Juvenile Meagre (Argyrosomus regius) Can Be Cultured Based on an Osmoregulatory Pilot Study

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