Nonfunctioning adrenal incidentaloma affecting central blood pressure and arterial stiffness parameters

Akkan, Tolga; Altay, Mustafa; Ünsal, Yasemin Aydoğan; Dağdeviren, Murat; Beyan, Eśin

doi:10.1007/s12020-017-1439-6

Cited by 18 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, some recent reports suggested that patients with NFA may also carry an increased CV risk compared with the general population, thus our study may underestimate the magnitude of cardiac damage associated with pACS. Among the hypotheses proposed, there is the possibility that NFAs produce excess cortisol in a cyclic manner, or during stress, or release excess steroid precursors, such as deoxycorticosterone and corticosterone (6,33,34).…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

Sbardella

Minnetti

D’Aluisio

et al. 2018

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

Sbardella

Minnetti

D’Aluisio

et al. 2018

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Many invasive, noninvasive methods and scoring systems are currently used for predicting CVDs. Arterial stiffness is also considered an independent risk indicator for cardiovascular diseases (3)(4)(5). Increased stiffness in central arteries leads to undesired hemodynamic consequences such as the expansion of pulse pressure (PP) and increased flow to microcirculation.…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones

Yıldız¹,

Altay²,

Yıldız

et al. 2019

Archives of Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

Objective: The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results: Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion: In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.

show abstract

“…In Table 2 we summarize all publications included in our review. In the investigated groups of AI patients an increased CIMT was observed, illustrating morphological changes in carotid arteries expressed by intimal hyperplasia and endothelial atherosclerosis, as well as increased PWV or AIx that are the indicators of arterial stiffness [54,55,[58][59][60]63,64]. Endothelial dysfunction in the form of FMD was also observed [55].…”

Section: Final Assessment Of the Available Cvd Markers In Patients Wimentioning

confidence: 77%

“…Similar conclusions were drawn by Akkan T. et al who observed higher PWV and AIx adjusted for heart rate in NFAI patients. Authors have observed a negative correlation between PWV and 24-h urinary free cortisol levels [63]. In the study of Sbardella E. et al significantly higher PWV in pACS patients was confirmed [64].…”

Section: Arterial Stiffness Indexmentioning

confidence: 89%

Markers of Subclinical Cardiovascular Disease in Patients with Adrenal Incidentaloma

et al. 2020

View full text Add to dashboard Cite

Due to the growing availability of imaging examinations the percentage of patients with incidentally diagnosed adrenal tumors has increased. The vast majority of these lesions are benign, non-functioning adenomas, although according to various estimates even up to 30%–50% of patients with adrenal incidentaloma may present biochemical hypercortisolemia, without typical clinical features of Cushing’s syndrome. Adrenal adenomas secreting small amounts of glucocorticoids may cause morphological and functional changes in the myocardium and blood vessels. Early stages of cardiovascular remodeling may be observed among asymptomatic patients with adrenal adenoma. Vascular changes precede the development of cardiovascular diseases and can increase morbidity and mortality in patients with adrenal incidentaloma. This risk may result not only from the traditional risk factors. Seemingly hormonally inactive adrenal tumors can indeed produce small amounts of glucocorticoids that have metabolic implications. Therefore, evaluation of patients with incidental adrenal findings presenting with subclinical cardiovascular disease seems of particular importance.

show abstract

Nonfunctioning adrenal incidentaloma affecting central blood pressure and arterial stiffness parameters

Cited by 18 publications

References 29 publications

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones

Markers of Subclinical Cardiovascular Disease in Patients with Adrenal Incidentaloma

Contact Info

Product

Resources

About