Nonfunctional double parathyroid carcinoma with incidental thyroid micropapillary carcinoma: a rare case

Abstract

Parathyroid carcinomas are rare endocrine tumors which comprise 0.3-5.6% of all causes of hyperparathyroidism. 90% of them are hormonally active, while 10% of them may be non-functional. They mostly occur in a single parathyroid gland. Concurrent involvement of both parathyroid glands is quite rare. A 57-year-old male patient was admitted to emergency department with the complaint of dyspnea. Thorax tomography revealed a retrosternal mass. The mass was thoracoscopically excised by thoracic surgeons. Histopathological examination result of the mass was reported as parathyroid carcinoma. Parathyroid scintigraphy performed and focal activity increase in the lower pole of the left lobe. Parathyroid hormone level was 118 pg/ml and calcium level was measured as 11.4 mg/dl. The patient with these findings was operated and pathological examination of excised left lower parathyroid tissue was reported as carcinoma. In addition, micropapillary carcinoma was detected in left thyroid lobectomy specimen.Our case was also unusual in that double parathyroid carcinoma, which is a rare condition, was hormonally inactive. We aimed to present our case in the light of the literature due to its rare occurrence.

An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature

“…Nonfunctional PC is much more infrequent than functional PC, and it has a decreased survival due to its absence of symptoms and perhaps to its aggressive biology [16,39]. To our knowledge, only one case of nonfunctional PC occurring with PTM was reported [40]. Interestingly, all cases with reported PC localization including the one here reported had a preponderance for the left lower side.…”

An unusual presentation of coexisting parathyroid carcinoma and papillary carcinoma thyroid: a case report and literature review

“…5 Most of the cases are functional, including our case, and only one case was non-functional parathyroid carcinoma occurring with papillary microcarcinoma and as double parathyroid carcinoma. 6 This non-functional parathyroid carcinomas has a reduced survival, mostly because of its lack of symptoms and aggressive biology. 7 In the reported cases, most of the parathyroid carcinoma were localized to the left lower neck, whereas our case was localized to the right lower neck.…”

Diagnostic dilemma in a rare case of nonfunctional parathyroid carcinoma at a referral facility in Northern Tanzania

“…11 histopathology analysis is a valuable tool to help to get a conclusive diagnosis. [12][13][14][15]…”