Nonfluoride Hypomineralizations in  the Permanent First Molars and Their  Impact on the Treatment Need

Leppäniemi, Anu; Lukinmaa, Pirjo‐Liisa; Alaluusua, Satu

doi:10.1159/000047428

Cited by 214 publications

(72 citation statements)

References 7 publications

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“…As regards the severity of MIH and HSPM, MIH is most often encountered in a mild form61621222728293031. Approximately one in four cases of MIH is severe.…”

Section: Discussionmentioning

confidence: 99%

Hypomineralized Second Primary Molars as Predictor of Molar Incisor Hypomineralization

Negre-Barber

Montiel-Company

Boronat-Catalá

et al. 2016

Sci Rep

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Molar incisor hypomineralization (MIH) is a developmental defect of dental enamel that shares features with hypomineralized second primary molars (HSPM). Prior to permanent tooth eruption, second primary molars could have predictive value for permanent molar and incisor hypomineralization. To assess this possible relationship, a cross-sectional study was conducted in a sample of 414 children aged 8 and 9 years from the INMA cohort in Valencia (Spain). A calibrated examiner (linear-weighted Kappa 0.83) performed the intraoral examinations at the University of Valencia between November 2013 and 2014, applying the diagnostic criteria for MIH and HSPM adopted by the European Academy of Paediatric Dentistry. 100 children (24.2%) presented MIH and 60 (14.5%) presented HSPM. Co-occurrence of the two defects was observed in 11.1% of the children examined. The positive predictive value was 76.7% (63.9–86.6) and the negative predictive value 84.7% (80.6–88.3). The positive likelihood ratio (S/1-E) was 10.3 (5.9–17.9) and the negative likelihood ratio (1-S/E) 0.57 (0.47–0.68). The odds ratio was 18.2 (9.39–35.48). It was concluded that while the presence of HSPM can be considered a predictor of MIH, indicating the need for monitoring and control, the absence of this defect in primary dentition does not rule out the appearance of MIH.

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“…As regards the severity of MIH and HSPM, MIH is most often encountered in a mild form61621222728293031. Approximately one in four cases of MIH is severe.…”

Section: Discussionmentioning

confidence: 99%

Hypomineralized Second Primary Molars as Predictor of Molar Incisor Hypomineralization

Negre-Barber

Montiel-Company

Boronat-Catalá

et al. 2016

Sci Rep

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“…performed the full exam. The MIH diagnosis was performed according to the EAPD (European Association of Paediatric Dentistry) criteria (12). Cases were defined as a subject with MIH phenotype, while controls were defined as subjects with no evidence of MIH (including no evidence of fluorosis).…”

Section: Methodsmentioning

confidence: 99%

Genes expressed in dental enamel development are associated with molar-incisor hypomineralization

Jeremias

Koruyucu

Küchler

et al. 2013

Archives of Oral Biology

174

182

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Genetic disturbances during dental development influence variation of number and shape of the dentition. In this study, we tested if genetic variation in enamel formation genes is associated with molar-incisor hypomineralization (MIH), also taking into consideration caries experience. DNA samples from 163 cases with MIH and 82 unaffected controls from Turkey, and 71 cases with MIH and 89 unaffected controls from Brazil were studied. Eleven markers in five genes [ameloblastin (AMBN), amelogenin (AMELX), enamelin (ENAM), tuftelin (TUFT1), and tuftelin-interacting protein 11 (TFIP11)] were genotyped by the TaqMan method. Chi-square was used to compare allele and genotype frequencies between cases with MIH and controls. In the Brazilian data, distinct caries experience within the MIH group was also tested for association with genetic variation in enamel formation genes. The ENAM rs3796704 marker was associated with MIH in both populations (Brazil: p=0.03; OR=0.28; 95% C.I.=0.06–1.0; Turkey: p=1.22e–012; OR=17.36; 95% C.I.=5.98–56.78). Associations between TFIP11 (p=0.02), ENAM (p=0.00001), and AMELX (p=0.01) could be seen with caries independent of having MIH or genomic DNA copies of Streptococcus mutans detected by real time PCR in the Brazilian sample. Several genes involved in enamel formation appear to contribute to MIH.

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“…Affected teeth often develop advanced carious lesions and, therefore, require substantial restorative care and repeated treatments (Leppäniemi et al 2001; Ghanim et al 2013b). Views of the oral healthcare providers from the European, Australian, New Zealand, South-east Asian, and Middle Eastern regions indicate that the clinical effect of MIH is increasing and poses a costly burden for public health (Weerheijm and Mejàre 2003; Crombie et al 2008; Ghanim et al 2011a; Bagheri et al 2014; Hussein et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A practical method for use in epidemiological studies on enamel hypomineralisation

Ghanim

Elfrink

Weerheijm

et al. 2015

Eur Arch Paediatr Dent

168

183

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With the development of the European Academy of Paediatric Dentistry (EAPD) judgment criteria, there has been increasing interest worldwide in investigation of the prevalence of demarcated opacities in tooth enamel substance, known as molar–incisor hypomineralisation (MIH). However, the lack of a standardised system for the purpose of recording MIH data in epidemiological surveys has contributed greatly to the wide variations in the reported prevalence between studies. The present publication describes the rationale, development, and content of a scoring method for MIH diagnosis in epidemiological studies as well as clinic- and hospital-based studies. The proposed grading method allows separate classification of demarcated hypomineralisation lesions and other enamel defects identical to MIH. It yields an informative description of the severity of MIH-affected teeth in terms of the stage of visible enamel destruction and the area of tooth surface affected (i.e. lesion clinical status and extent, respectively). In order to preserve the maximum amount of information from a clinical examination consistent with the need to permit direct comparisons between prevalence studies, two forms of the charting are proposed, a short form for simple screening surveys and a long form desirable for prospective, longitudinal observational research where aetiological factors in demarcated lesions are to be investigated in tandem with lesions distribution. Validation of the grading method is required, and its reliability and usefulness need to be tested in different age groups and different populations.

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Nonfluoride Hypomineralizations in the Permanent First Molars and Their Impact on the Treatment Need

Cited by 214 publications

References 7 publications

Hypomineralized Second Primary Molars as Predictor of Molar Incisor Hypomineralization

Hypomineralized Second Primary Molars as Predictor of Molar Incisor Hypomineralization

Genes expressed in dental enamel development are associated with molar-incisor hypomineralization

A practical method for use in epidemiological studies on enamel hypomineralisation

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