Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat

Narita, Minoru; Oyabu, Akiko; Imura, Yoshio; Kamada, Nanao; Yokoyama, Tomomi; Tano, Kaori; Uchida, Akio; Narita, Naoko

doi:10.1016/j.neures.2009.09.001

Cited by 83 publications

(69 citation statements)

References 20 publications

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“…However, more recent studies suggest that there should be many other factors, such as epigenetic factors [1][2][3] or parenting, 4,5 which are involved in the establishment of clinical features in the later life of the patients. This makes it difficult to diagnose these disorders simply by the current method of diagnosis, which is conducted by a specialist's medial interview using diagnostic criteria, such as those defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders 5.…”

Section: Introductionmentioning

confidence: 99%

Proposal of auxiliary diagnosis index for autism spectrum disorder using near-infrared spectroscopy

et al. 2016

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Abstract. Lack of a diagnostic index is a problem that needs to be overcome in the diagnosis of autism spectrum disorder (ASD), because this problem prevents an objective assessment based on biomarkers. This paper describes the development of a diagnostic index for ASD using near-infrared spectroscopy (NIRS). We investigated continuous prefrontal hemodynamic changes depending on reciprocal disposition of working memory and nonworking memory tasks using two-channel NIRS. NIRS signals in the prefrontal cortex were compared between high-functioning ASD subjects (n ¼ 11) and typically developed (TD) subjects (n ¼ 21). The brain activities of the TD subjects were related to experimental design. These results were not confirmed in brain activities of ASD subjects, although the task performance rate was almost equivalent. The brain activities of TD subjects and ASD subjects were evaluated using a weighted separability (WS) index obtained from the feature phase of oxy-hemoglobin and its differential value. Calculation of the t -test (TD subject versus ASD subject) confirmed that WS was significant. This result showed that the proposed index was useful for evaluation of the brain activity of ASD subjects.

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Section: Introductionmentioning

confidence: 99%

Proposal of auxiliary diagnosis index for autism spectrum disorder using near-infrared spectroscopy

et al. 2016

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“…In the VPA rat model of autism, VPA is administered to pregnant dams on the 12th day of gestation. Many studies have examined individual autism-specific deficits associated with the VPA rat model, including morphology of motor cortex neurons [4], cerebellar anomalies [5], immunological alterations [6], repetitive behaviours [7], electrophysiological evoked response latency [8], and social-emotional functioning [9,10]. To our knowledge, however, there has not been a comprehensive examination of the viability of the VPA rat model of autism, at the neuro-anatomical and behavioural level.…”

Section: Introductionmentioning

confidence: 99%

Effects of Rat Prenatal Exposure to Valproic Acid on Behaviour and Neuro-Anatomy

et al. 2012

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Autism is a highly debilitating disorder that has recently displayed a dramatic rise in incidence. In order to realistically study preventative and remedial strategies, it is important that we develop and understand useful animal models of the disorder. The purpose of this study was to investigate the efficacy of the prenatal valproic acid (VPA) rat model of autism by examining the neuro-anatomical and behavioural outcomes of offspring exposed to this paradigm. The VPA-treated rats exhibited behavioural changes in the delayed non-match-to-sample task, novel object recognition, activity box, and Whishaw tray reaching task. Anatomically, there was a reduction in brain weight and cortical thickness, along with decreased dendritic branching in the orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC), and decreased spine density in the mPFC, OFC, and cerebellum. Behavioural and anatomical findings from this study produced reliable results indicating that prenatal VPA exposure may be a viable model for the study of autism in rats.

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“…In a population of 100 Swedish thalidomide embryopathy cases, at least four met full diagnostic criteria for autism (Stromland et al, 1994). Animal models have also demonstrated that early serotonergic neural development is disrupted in rats exposed to thalidomide or valproic acid on the ninth day of gestation, conferring increased risk for the development of ASD-related behaviours (Narita et al, 2010). Mercury (Hg), because of its known neurotoxicity, has drawn particular attention in relation to the neurodevelopment of individuals with autism, and a number of studies have compared the level of Hg in blood, hair, or urine in children with autism versus without autism.…”

Section: Other Factorsmentioning

confidence: 99%

Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities

Kaufman¹,

Noor²,

Ayub³

et al. 2011

Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment

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Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat

Cited by 83 publications

References 20 publications

Proposal of auxiliary diagnosis index for autism spectrum disorder using near-infrared spectroscopy

Proposal of auxiliary diagnosis index for autism spectrum disorder using near-infrared spectroscopy

Effects of Rat Prenatal Exposure to Valproic Acid on Behaviour and Neuro-Anatomy

Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities

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