The ability to create and manipulate the spatio-temporal potentials is essential in the diverse fields of science and technology. Here, we introduce an optical feedback trap system based on a high precision position detection and an ultrafast feedback control of a Brownian particle in the optical tweezers to generate spatio-temporal virtual potentials of the desired shape in a controlled manner. As an application, we study nonequilibrium fluctuation dynamics of the particle in a time-varying virtual harmonic potential and validate the Crooks fluctuation theorem in highly nonequilibrium condition.
IntroductionFor the past three decades, there has been significant progress in the field of stochastic and information thermodynamics, where general laws such as fluctuation theorems and Jarzynski relations applicable to nonequilibrium phenomena have been discovered [1][2][3]. Many of these nonequilibrium relations are validated experimentally, thanks to the development of new technologies, which facilitates trapping and manipulation of Brownian particles, such as optical tweezers (OT). The OT has been a powerful tool for trapping and controlling Brownian particles in fluid [4,5]. It can trap and locate an object with subnanometer resolution and is capable of probing piconewton forces. As a result, it has been successfully used as an experimental tool in the diverse fields of science and engineering [6,7]. It has been used in biophysical experiments for the purpose of the position and force spectroscopy [8,9]. The OT has also been used in the field of nonequilibrium and information thermodynamics to demonstrate the validity of various fundamental relations [10][11][12][13]. For example, varying laser intensity with controlled artificial thermal noise allows one to demonstrate the Brownian nano-heat engine [10]. Placing two traps close enough can create a double-well potential to study Kramers' transition rate [12], stochastic resonance [11], and Landauer's principle of information erasure [14]. However, these prior studies could not modulate the barrier height and the tilt of the double-well potential in a controlled manner. Hence, despite the partial success of the optical tweezers in the study of the stochastic and information thermodynamics, its application is still limited when the generation of the mathematically-driven time-varying arbitrary shaped potential is required.Recently, Cohen et al. developed a feedback-based technique called anti-Brownian electrokinetic (ABEL) trap by applying the feedback force in the form of electrophoretic force, which enables trapping of a nano-sized object in solution [15,16]. The ABEL trap can also create the arbitrarily-shaped potential [17,18] and has been used to study the dynamics of a Brownian particle in a double-well potential [19][20][21]. However, the design and the implementation of the ABEL trap are quite complicated. In particular, ABEL trap requires micro-fabricated 2D flow channel that introduces complicated boundary effect between the trapped particle and the wall of...