Nonepithelial Neoplasms of the Pancreas: Radiologic-Pathologic Correlation, Part 1—Benign Tumors:From the Radiologic Pathology Archives

Abstract

Solid and cystic pancreatic neoplasms are being recognized more frequently with increasing utilization and spatial resolution of modern imaging techniques. In addition to the more common primary pancreatic solid (ductal adenocarcinoma) and cystic neoplasms of epithelial origin, nonepithelial neoplasms of the pancreas may appear as well-defined solid or cystic neoplasms. Most of these lesions have characteristic imaging features, such as a well-defined border, which allows differentiation from ductal adenocarcinoma. Solid masses include neurofibroma, ganglioneuroma, leiomyoma, lipoma, and perivascular epithelioid cell tumor (PEComa). Schwannomas and desmoid tumors can be solid or cystic. Cystic tumors include mature cystic teratoma and lymphangioma. Lipoma, PEComa, and mature cystic teratoma can contain fat, and ganglioneuroma and mature cystic teratoma may contain calcification. Although these unusual benign neoplasms are rare, the radiologist should at least consider them in the differential diagnosis of well-defined lesions of the pancreas. The goal of this comprehensive review is to improve understanding of these rare primary pancreatic mesenchymal tumors.

Metastatic leiomyosarcoma to the pancreas diagnosed on endoscopic ultrasound‐guided fine needle aspiration – A report of two cases with review of spindle cell lesions of pancreas

“…Mesenchymal spindle cell neoplasms are one of the most challenging aspects of cytology with considerable overlap in morphology and ICC. Gastrointestinal stromal tumour (GIST), leiomyoma, ganglioneuroma,schwannoma, desmoids fibromatosis, solitary fibrous tumour (SFT), inflammatory myofibroblastic tumour, low‐grade myofibroblastic sarcoma and neurofibroma are all reported in the pancreas. These lesions show tightly cohesive cellular fragments of spindle cells variably arranged in fascicular pattern associated with metachromatic matrix material.…”

Pancreatic Lymphangioma Mimicking Mucinous Cystadenoma: A Report of a Rare Case

“…Pancreatic lymphangioma (PL), a rare benign neoplasm of pancreas was rst described by Koch in 1931 [7] . PL can affect all age groups especially female adults, with an incidence of less than 1% of all lymphangiomas and only accounting for 0.2% of all pancreatic lesions [3,4] . The etiology of PL is still not well de ned.…”

“…Pancreatic lymphangioma (PL) is extremely rare in clinical practice, accounting for less than 1% of all lymphangiomas and only 0.2% of all pancreatic lesions [3] . It was usually encountered in pancreatic parenchyma or peripancreatic soft tissues with a female predominance [4] and presented as large, solitary, multi-or unilocular lesions. Most PL patients were asymptomatic, their masses were usually detected occasionally in medical checkups or treatments for other unrelated diseases [5] .…”

Primary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Review

“…Initial suspicions favor ductal adenocarcinoma or less frequently, pancreatic neuroendocrine tumor [19–22]. In patients with a history of a malignancy, metastases to the pancreas from another primary site should also be considered [19, 23–25].…”