Nonenzymatic, prebiotic aminoacylation couples chirality of RNA and protein
Joshua A. Davisson,
Evan M. Kalb,
Isaac J. Knudson
et al.
Abstract:Life as we know it depends on the homochirality of nucleic acids and proteins. However, there is no widely accepted explanation for why life uses only D-sugars for nucleic acids and L-amino acids for proteins. Here we demonstrate a prebiotically plausible method of nonenzymatic aminoacylation in a water ice-eutectic phase. These reactions produce high yields of aminoacyl-tRNAs, which are active in translation. Surprisingly, we discovered these nonenzymatic aminoacylation conditions were stereoselective, favori… Show more
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