Nonenzymatic electrochemical sensor based on imidazole-functionalized graphene oxide for progesterone detection

Gevaerd, Ava; Blaskievicz, Sirlon F.; Zarbin, Aldo J. G.; Orth, Elisa S.; Bergamini, Márcio F.; Marcolino‐Júnior, Luiz H.

doi:10.1016/j.bios.2018.04.044

Cited by 71 publications

(28 citation statements)

References 51 publications

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“…These additional bonds revealed that the IL group and GMA monomer had been immobilized on silica. In SiO 2 @IL@MIP, three more peaks (1389.87 cm −1 for ‐C–O‐, 1734.32 cm −1 for ‐C=O and 2951.25 cm −1 for the alkyl chain) confirmed that MIP was coated on silica successfully . The SEM images in Figure show that the smooth surface of activated silica (Figure 4A) was covered by MIP (Figure 4B).…”

Section: Resultsmentioning

confidence: 81%

Multi‐phase extraction of ephedrine from Pinellia ternata and herbal medicine using molecular imprinted polymer coated ionic liquid‐based silica

Fang

Xie

Lin

et al. 2019

Phytochemical Analysis

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Introduction Ephedrine is a typical compound found in lots of plant species that is used in several medicines for the treatment of asthma and bronchitis. However, excess amounts are harmful to humans, so it needs to be removed. Objective This study developed a multi‐phase extraction (MPE) method with a molecular imprinted polymer (MIP) coated ionic liquid (IL)‐based silica (SiO2@IL@MIP) to simultaneously extract and separate ephedrine from Pinellia ternata, 10 medicines, and urine samples. Methods IL was immobilized on silica. Subsequently, the IL was combined with the functional monomer, followed by the addition of the crosslinker and template. The resulting sorbent was applied to the MPE, and the extraction, washing and elution solvents were evaluated. Results Fourier‐transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) confirmed the synthesis of SiO2@IL@MIP. A maximum adsorption amount of 5.76 mg/g was obtained at 30°C at a neutral pH. In MPE, 10.00 mL of methanol could extract all the ephedrine from Pinellia ternata. The interference was removed by washing with 4.00 mL of water, ethanol, and acetonitrile. Finally, 8.00 mL of methanol/acetic acid (99:1, v/v) was applied as the elution solvent. The following were extracted: 5.50 μg/g of ephedrine from Pinellia ternata, 0.00–46.50 μg/g from the 10 herbal medicines, and 68.70–102.80 μg/mL in the urine samples. Conclusion The proposed method was applied successfully to the simultaneously extraction and separation of ephedrine from plants and medicines. These results are expected to provide important data for the development of new methods for the separation and purification of bioactive compounds.

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Section: Resultsmentioning

confidence: 81%

Multi‐phase extraction of ephedrine from Pinellia ternata and herbal medicine using molecular imprinted polymer coated ionic liquid‐based silica

Fang

Xie

Lin

et al. 2019

Phytochemical Analysis

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“…Gevaerd et al designed and synthesized imidazole-functionalized graphene oxide (GO-IMZ) as non-enzymatic electrochemical sensor for the detection of progesterone [14]. Progesterone (P4) plays an important role in the stabilization and maintenance of gestation as most important progestogen of mammals.…”

Section: Detection Of Proteinsmentioning

confidence: 99%

Nanocomposite-Based Graphene for Nanosensor Applications

Cheng¹,

Ou²

2020

Nanorods and Nanocomposites

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Nanocomposites based on carbon nanomaterial particularly in graphene oxide, graphene quantum dots, and doped graphene quantum dots with improved biocompatibility have been increasing interests in the field of drug delivery, biosensor, energy, imaging and electronic. These nanomaterials as new kinds of fluorescent probes and electrochemical sensors all display ultrasmall size, good photostability, and excellent biocompatibility. In this chapter, we summarize an updated advance in the development of graphene and its related derivatives of synthesis methods and biomedical applications as nanosensors for detection of metal ions, inorganic ions, amino acids, proteins, saccharides and small molecules, drug molecules, and so on.

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“…The functionalization of graphene or graphene oxide (GO) nanosheets confers specific properties to the composites, e.g., their chemical selectiveness, solubility, thermal and electronic conductivity (Bueno et al, 2017;Xiang et al, 2016). Such enhancement allows the employment of functionalized graphenebased materials in several fields, such as chemistry and catalysis (Ye et al, 2018;Rana and Jonnalagadda, 2017), biomedicine (Kenry et al, 2018;Yu et al, 2018;Zeng et al, 2017), electronics (Scidà et al, 2018;Gevaerd et al, 2018;Chiu et al, 2017;Zhao et al, 2017), energy (Li and Zhi, 2018;Sadri et al, 2017) and environmental sciences and technologies (Ren et al, 2018;Othman et al, 2018;Khurana et al, 2018). Due to their large specific surface area and rich porous structure, carbonaceous materials usually show high adsorption capacity and have been successfully employed as adsorbents of organic pollutants .…”

Section: Introductionmentioning

confidence: 99%

Functionalized Graphene-Based Materials as Innovative Adsorbents of Organic Pollutants: A Concise Overview

Fraga

Carvalho

Ghislandi

et al. 2019

Braz. J. Chem. Eng.

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The functionalization of graphene nanosheets is the cutting edge of materials sciences nowadays. Such research promotes the development of innovative, low cost and highly capable sorbents. This review article aims to assemble the available information on functionalized graphene used for the adsorption of organic pollutants and establishes a critical comparison between the data reported in the literature. Various optimal experimental conditions (pH, temperature, contact time, adsorbent dosage) and adsorbent characterization methods (FTIR, Raman, XPS spectra, XRD, TEM and AFM) have been listed to enlighten adsorption mechanisms, capacity and limiting aspects. Moreover, adsorption isotherms, kinetics and thermodynamic data of different functionalized graphene-based materials towards a wide range of organic pollutants were analyzed and tabulated. In each evaluation topic, environmental and human health protection is subject for discussion, as well as the scientific breakthrough works available in high impact journals in the field.

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Nonenzymatic electrochemical sensor based on imidazole-functionalized graphene oxide for progesterone detection

Cited by 71 publications

References 51 publications

Multi‐phase extraction of ephedrine from Pinellia ternata and herbal medicine using molecular imprinted polymer coated ionic liquid‐based silica

Multi‐phase extraction of ephedrine from Pinellia ternata and herbal medicine using molecular imprinted polymer coated ionic liquid‐based silica

Nanocomposite-Based Graphene for Nanosensor Applications

Functionalized Graphene-Based Materials as Innovative Adsorbents of Organic Pollutants: A Concise Overview

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