Nonenzymatic amperometric response of glucose on a nanoporous gold film electrode fabricated by a rapid and simple electrochemical method

Xia, Yue; Huang, Wei; Zheng, Jianbin; Niu, Zhen-Jiang; Li, Zelin

doi:10.1016/j.bios.2011.01.044

Cited by 172 publications

(107 citation statements)

References 41 publications

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“…At a traditional planar electrode, this analyte is difficult to be measured and thus, an enzyme (e.g., glucose oxidase) is often incorporated into the electrochemical sensor platform [152,153]. Recently, however, the nonenzymatic oxidation of glucose on nanoporous gold has been described in a number of reports [79,151,[154][155][156][157]. In 2008, Yin et al reported on the oxidation of glucose on nanoporous gold with different ligament sizes (6-250 nm) and also studied the effect of residual silver (6.8 to 37.9%) [154].…”

Section: Small Molecule Sensingmentioning

confidence: 99%

“…A simple way to make a nanoporous gold-like structure is to just roughen/etch a planar gold electrode using a repetitive square-wave oxidation reduction cycle and/or via application of large potentials for a given period of time [24,157,[164][165][166][167][168][169][170][171][172]. One example of an electrode made via an anodizing procedure had an area 9.9 times greater than planar gold and was used to make a DNA sensor for detection of the PML/RAR fusion gene [165].…”

Section: Other Nanoporous Gold Sensorsmentioning

confidence: 99%

“…Other examples of electrodes include those used for the electrochemical detection of hydrogen peroxide (roughness factor of 57.4) [169], thrombin detection (roughness factor of 34) [170], and detection of osteosarcoma-related gene (roughness factor of 42.5) [168]. An example of nanoporous gold prepared using a modified version of this procedure had a roughness factor over 200 and was used in the electrocatalytic oxidation of glucose with promising results [157].…”

Section: Other Nanoporous Gold Sensorsmentioning

confidence: 99%

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Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Collinson

2013

ISRN Analytical Chemistry

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Nanoporous gold prepared by dealloying Au:Ag alloys has recently become an attractive material in the field of analytical chemistry. This conductive material has an open, 3D porous framework consisting of nanosized pores and ligaments with surface areas that are 10s to 100s of times larger than planar gold of an equivalent geometric area. The high surface area coupled with an open pore network makes nanoporous gold an ideal support for the development of chemical sensors. Important attributes include conductivity, high surface area, ease of preparation and modification, tunable pore size, and a bicontinuous open pore network. In this paper, the fabrication, characterization, and applications of nanoporous gold in chemical sensing are reviewed specifically as they relate to the development of immunosensors, enzyme-based biosensors, DNA sensors, Raman sensors, and small molecule sensors.

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Section: Small Molecule Sensingmentioning

confidence: 99%

Section: Other Nanoporous Gold Sensorsmentioning

confidence: 99%

Section: Other Nanoporous Gold Sensorsmentioning

confidence: 99%

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Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Collinson

2013

ISRN Analytical Chemistry

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“…The method to fabricate NPG electrode is the same as in our previous report (the detailed preparation procedure was provided in Supplementary Material) [10]. A CoO x / NPG electrode was established by two step electrochemical methods [23].…”

Section: Preparation Of Npg and Coo X /Npg Electrodementioning

confidence: 99%

“…Among them, nanostructured gold is a kind of noticeable candidate for the development of nonenzymatic glucose sensor because of its excellent chemical stability and biocompatibility, including porous gold [6], gold nanotube [7], gold nanowire [8], gold nanocoral [9]. It is worth mentioning that, as far as we know, our group provided the most rapid and straightfoward strategy to construct a nanoporous gold (NPG) electrode for nonenzymatic glucose determination, i.e., one-step anodizing a pure gold substrate in chloride ion containing electrolytes within 5 minutes by applying a single potential step [10,11]. The fabricated nonenzymatic glucose sensors showed high sensitivity and wide linear range in both phosphate buffer solution (PBS) and NaOH solution.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Fabrication of Cobalt Oxides/Nanoporous Gold Composite Electrode and its Nonenzymatic Glucose Sensing Performance

Zhou

Tang²,

Xia

et al. 2016

Electroanalysis

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A nonenzymatic glucose sensor was successfully established by electrochemically decorating cobalt oxides (CoOx) on a nanoporous gold electrode (NPG) using cobalt hexacyanoferrate (CoHCF) as a precursor. It exhibited high sensitivity and long‐term stability as well as satisfactory quantification of glucose concentration in human serum samples. The morphology and surface analysis of the resulting CoOx/NPG were carefully characterized. Two detection methods, cyclic voltammetry and amperometry, were employed to evaluate the performance of CoOx/NPG towards glucose sensing in alkaline solution. Using cyclic voltammetry, at −0.5 V, the glucose partial oxidation peak current is linear to the glucose concentration up to 14 mM with a sensitivity of 283.7 µA mM−1 cm−2. A linear amperometric response at 0.55 V was obtained in the glucose concentration range from 2 µM to 2 mM with a sensitivity of 2025 µA mM−1 cm−2 and a response time <3 s.

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Electrochemical Nano‐Roughening of Gold Microstructured Electrodes for Enhanced Sensing in Biofluids**

et al. 2023

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A key challenge for sensor miniaturization is to create electrodes with smaller footprints, while maintaining or increasing sensitivity. In this work, the electroactive surface of gold electrodes was enhanced 30‐fold by wrinkling followed by chronoamperometric (CA) pulsing. Electron microscopy showed increased surface roughness in response to an increased number of CA pulses. The nanoroughened electrodes also showed excellent fouling resistance when submerged in solutions containing bovine serum albumin. The nanoroughened electrodes were used for electrochemical detection of Cu2+ in tap water and of glucose in human blood plasma. In the latter case, the nanoroughened electrodes allowed highly sensitive enzyme‐free sensing of glucose, with responses comparable to those of two commercial enzyme‐based sensors. We anticipate that this methodology to fabricate nanostructured electrodes can accelerate the development of simple, cost‐effective, and high sensitivity electrochemical platforms.

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Nonenzymatic amperometric response of glucose on a nanoporous gold film electrode fabricated by a rapid and simple electrochemical method

Cited by 172 publications

References 41 publications

Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Electrochemical Fabrication of Cobalt Oxides/Nanoporous Gold Composite Electrode and its Nonenzymatic Glucose Sensing Performance

Electrochemical Nano‐Roughening of Gold Microstructured Electrodes for Enhanced Sensing in Biofluids**

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