Nondominant small follicles are a promising source of mature oocytes in modified natural cycle in vitro fertilization and embryo transfer

Teramoto, Shokichi; Osada, Hiroyuki; Sato, Yasunori; Shozu, Makio

doi:10.1016/j.fertnstert.2016.03.015

Cited by 25 publications

(39 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was also a lower incidence of prior IVF failure in SF-BTs. These findings were consistent with previous findings that the higher the ovarian reserves, the more blastocysts we can obtain from SFs (2). ICSI was used for all oocytes derived from SFs, whereas ICSI was used for 80% of LF-derived oocytes, and the conventional insemination procedure was used for the remaining 20% of oocytes.…”

Section: Clinical Characteristicssupporting

confidence: 92%

“…We conducted a retrospective cohort study on BTs that were performed between January 2012 and December 2014 at our infertility clinic. The inclusion criteria were as follows: [1] the blastocysts were grown from oocytes that were retrieved by the modified natural cycle IVFs, conducted as the initial one or two attempts of IVF-ET for the patients in our clinic; [2] both large (dominant, R11 mm) follicles and small (nondominant, %10 mm) follicles were concurrently aspirated at oocyte retrieval; [3] oocytes had matured to metaphase II when they were inseminated; and [4] patients were between 30 and 40 years old. Patients who did not agree with natural cycle IVF or this study were excluded.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…All women had a R1-year history of infertility, and 30.2% had experienced IVF-ET failure(s) that occurred before visiting our clinic. A total of 292 cycles (128 SF-BTs and 164 LF-BTs) overlapped with the cycles that have been previously reported (2). This study was approved by the institutional review board.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…Modified natural cycle IVF-ET using concurrent oocyte retrievals from LFs and SFs was conducted as reported elsewhere (2). Briefly, follicular growth was monitored for a dominant follicle, and the LH surge was triggered by nasal buserelin (300 mg) when the dominant follicle reached R16 mm in diameter and the serum E 2 level exceeded 200 pg/mL.…”

Section: Ivf-etmentioning

confidence: 99%

“…In a previous study, we demonstrated that nondominant small follicles (SFs) are a promising source of additional mature oocytes in natural cycle IVF-ET (2). We needle-aspirated SFs that were concurrently residing with a large (dominant) follicle and successfully achieved mature oocytes (metaphase II) in most women, which yielded blastocysts and eventually live births.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Pregnancy and neonatal outcomes of small follicle–derived blastocyst transfer in modified natural cycle in vitro fertilization

Teramoto¹,

Osada²,

Sato

et al. 2019

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

Objective: To compare the efficacy and safety of blastocyst transfer derived from small follicles (SF; %10 mm) and large follicles (LF; R11 mm). Design: Retrospective cohort study. Setting: Private clinic. Patient(s): Patients (n ¼ 1,072) 30-40 years old who underwent blastocyst transfer (BT; n ¼ 1,247) between January 2012 and December 2014. Intervention(s): Oocytes retrieved during a modified natural cycle from both LF and SF were fertilized by a conventional method or intracytoplasmic sperm injection. The blastocysts were frozen, thawed, and transferred one by one in the following spontaneous ovulatory cycles or hormone replacement cycles. Main Outcome Measure(s): BT resulted in live births and major congenital anomalies. Result(s): SF-derived BTs (n ¼ 597) yielded 55 chemical abortions (9.2%), 73 clinical abortions (12.2%), and 261 live births (43.8%), whereas LF-derived BTs (n ¼ 650) yielded 71 chemical abortions (10.9%), 73 clinical abortions (11.2%), and 311 live births (47.9%). These incidences were not statistically different between SF-and LF-derived BTs. The incidence of abnormal karyotypes was also not statistically different between SF-and LF-derived spontaneous abortions (71% [39/55] vs. 72% [40/55], respectively). The incidence of major congenital anomalies in neonates did not differ between SF-and LF-derived pregnancies (1.5% and 1.3%, respectively; relative risk ¼ 1.10, 95% confidence interval [0.55-3.21]). Conclusion(s): SF-derived BT is as efficacious and safe as LF-derived BT. (Fertil Steril Ò 2019;111:747-52. article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) El resumen está disponible en Español al final del artículo.

show abstract

Section: Clinical Characteristicssupporting

confidence: 92%

Section: Study Design and Participantsmentioning

confidence: 99%

Section: Study Design and Participantsmentioning

confidence: 99%

Section: Ivf-etmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Pregnancy and neonatal outcomes of small follicle–derived blastocyst transfer in modified natural cycle in vitro fertilization

Teramoto¹,

Osada²,

Sato

et al. 2019

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

show abstract

Relationship between follicular size and developmental capacity of oocytes under controlled ovarian hyperstimulation in assisted reproductive technologies

Tamura

Kawamoto-Jozaki

Fujimura

et al. 2021

Reprod Medicine & Biology

View full text Add to dashboard Cite

Purpose We investigate the relationships between oocyte developmental capacity and follicular size of its origin in Japanese women: those undergoing conventional IVF (cIVF) and ICSI, respectively. Methods A total of 3377 follicles were punctured separately and were classified into three groups (large, medium, and small) by their diameters. A total of 1482 retrieved oocytes were individually cultured and received cIVF or ICSI. The oocytes receiving ICSI were denuded and the number of mature (MII) oocytes was counted. Results The oocyte retrieval rates and the proportion of MII oocytes were significantly lower in small follicles than in large follicles. Under cIVF, the fertilization rate was significantly lower in oocytes from small follicles than large follicles. Under ICSI, the fertilization rate for MII oocytes was not significantly related to follicular size. Follicular size was not significantly related to the development potential to blastocyst and pregnancy rate for either the cIVF oocytes or the ICSI oocytes. Conclusions Although the fertilization rate by cIVF is low in oocytes from small follicles due to the lower proportion of mature oocytes, their development potential is comparable to that of oocytes from larger follicles if they could be fertilized. Under ICSI using mature oocytes, their development potential is not related to follicular size.

show abstract

Development of IVM Treatment: Combination of Natural Cycle IVF with IVM

Lim

Chian

2017

Development of in Vitro Maturation for Human Oocytes

View full text Add to dashboard Cite

Nondominant small follicles are a promising source of mature oocytes in modified natural cycle in vitro fertilization and embryo transfer

Abstract: Nondominant small follicles are a promising supplementary source of mature oocytes for natural cycle IVF.

Cited by 25 publications

References 14 publications

Pregnancy and neonatal outcomes of small follicle–derived blastocyst transfer in modified natural cycle in vitro fertilization

Pregnancy and neonatal outcomes of small follicle–derived blastocyst transfer in modified natural cycle in vitro fertilization

Relationship between follicular size and developmental capacity of oocytes under controlled ovarian hyperstimulation in assisted reproductive technologies

Development of IVM Treatment: Combination of Natural Cycle IVF with IVM

Contact Info

Product

Resources

About