Nondiabetic renal disease in patients with diabetes mellitus

Kasinath, Balakuntalam S.; Mujais, Salim; Spargo, Benjamin H.; Katz, Adrian I.

doi:10.1016/0002-9343(83)90442-4

Cited by 95 publications

(58 citation statements)

References 18 publications

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“…This was in accordance with previous studies where the prevalence of NDRD was found to range from 45% to 57%,612–14 but different from other studies where the prevalence of NDRD was around 7-10% 1516. This low prevalence could be explained by the different selection criteria for doing renal biopsy in such patients.…”

Section: Discussionsupporting

confidence: 87%

Renal biopsy in patients with type 2 diabetes mellitus: indications and nature of the lesions

Ghani

Waheeb

Sahow

et al. 2009

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:The prevalence of non diabetic renal disease (NDRD) among patients with type 2 diabetes mellitus varies widely depending on the selection criteria and the populations being studied. The aim of this study was to evaluate the renal biopsies performed on type 2 diabetic patients for suspicion of NDRD and to correlate the pathological with the clinical and laboratory findings.SUBJECTS AND METHODS:We selected and reviewed biopsies performed on type 2 diabetics for clinically suspected NDRD from January 2006 to December 2008 at a single hospital. Clinical and laboratory data were analyzed in relation to the histopathology findings. Patients were grouped into either group I with isolated DGS or group II with NDRD on top of DGS.RESULTS:Thirty-one biopsies were performed on type 2 diabetic patients; Seventeen patients (54.8%) were males. Mean age was 50.68 (11.29) years. The mean duration of diabetes was 9.33 (3.6) years. Renal biopsy showed that among the studied group 14 patients (45.2%) showed NDRD on top of DGS. Crescentic glomerulonephritis was the commonest finding seen in 3 cases (21.4% of group II cases) followed by acute tubulointerstitial nephritis and hypertensive changes each was seen in 2 cases (14.4%). Other findings included IgA nephropathy, primary focal segmental glomerulosclerosis, rhabdomyolysis, membranoproliferative glomerulonephritis each of them was seen in one case (7.1%). Group I had a significantly higher level of proteinuria 4.97 (2.08) gm/24 hrs urine than group II 2.72 (1.09) gm/24 hrs urine (P=.003). There was no significant difference between the two groups in age, duration of diabetes, gender, presence of hypertension, hematuria, serum creatinine or glomerular filtration rate.CONCLUSION:The present study showed that crescentic glomerulonephritis is the commonest NDRD among diabetic patients. A higher level of proteinuria was reported among those with NDRD superimposed on DGS. So, Renal biopsy should be performed in diabetics when the clinical scenario is atypical.

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Section: Discussionsupporting

confidence: 87%

Renal biopsy in patients with type 2 diabetes mellitus: indications and nature of the lesions

Ghani

Waheeb

Sahow

et al. 2009

Annals of Saudi Medicine

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“…The mean age of the patients who received a transplant was significantly lower than that of those did not (41 (2) v 48 (2), p<0 05). Of these 33 patients, 22 had been previously treated with peritoneal dialysis, nine with haemodialysis, and two had received transplants before dialysis. Six patients had a combined pancreatic and renal transplant.…”

Section: Acceptance Rates In the Northern Regionmentioning

confidence: 99%

Renal replacement treatment for diabetic patients in Newcastle upon Tyne and the Northern region, 1964-88.

Catalano

Goodship

Tapson

et al. 1990

BMJ

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“…The findings of thickening of the capillary loops, spike formation of basement membrane, and diffuse and membranous deposition of IgG and C3 in addition to paucity of typical diabetic glomerular nodular lesions suggest that mild stage (stage I-II) idiopathic membranous nephropathy had been present before admission in this case. Kasinath et al reported that renal disease other than diabetic nephropathy was found in 10 of 122 diabetic patients who underwent renal biopsy and that idiopathic membranous nephropathy was the most frequent non-diabetic renal lesion in diabetic patients (3). It has been reported that membranous nephropathy evolved into RPGN by means of immune complexes (18,19).…”

Section: Discussionmentioning

confidence: 99%

“…The progression of renal dysfunction in patients with diabetes is affected by hyperglycemia, hypertension, hyperlipidemia, high-protein diet, smoking, genetic factors, and the administration of nephrotoxic drugs, while treatment with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor antagonists slows renal damage (1). The rapid deterioration of renal function as well as the presence of hematuria is an important finding suggesting the presence of other glomerulopathy superimposed on diabetic nephropathy (2,3). However, in very old patients with long-standing diabetes, the diagnosis of other glomerulonephropathy is often difficult because of avoidance of intensive invasive examination such as renal biopsy due to age.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Complicated with Rapidly Progressive Glomerulonephritis in an Elderly Patient

et al. 2005

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Nondiabetic renal disease in patients with diabetes mellitus

Cited by 95 publications

References 18 publications

Renal biopsy in patients with type 2 diabetes mellitus: indications and nature of the lesions

Renal biopsy in patients with type 2 diabetes mellitus: indications and nature of the lesions

Renal replacement treatment for diabetic patients in Newcastle upon Tyne and the Northern region, 1964-88.

Diabetes Mellitus Complicated with Rapidly Progressive Glomerulonephritis in an Elderly Patient

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