Nondestructive prediction of oren extract powder, a herbal medicine, in suppositories by chemometric near-infrared spectroscopy

Abstract

Near-infrared (NIR) spectroscopy combined with chemometrics has been utilized in predictions of natural medicine content without destroying samples. Suppositories (oren powdered extract content 0, 0.5, 1.0, 2.5, 10, 12.5, and 15%) were produced by mixing oren powdered extract with macrogol mixture consisting of 1 part macrogol 1500 and 2.5 parts macrogol 4000 at 54°C, and pouring the melt mixture into a plastic container. NIR spectra of the 10 prepared samples were recorded 10 times, and a total of 100 spectra were randomly divided into two data sets, one for calibration and the other for validation. The calibration model for the oren content of the suppository was calculated based on NIR spectra using a partial least-squares regression analysis after pre-treatment (smoothing and the multiplicative scatter correction). The relationship between the actual and predicted values for calibration and validation models had a straight line with correlation coefficients of 0.9936 and 0.9898, respectively. The regression vector result of the calibration model indicates that the peaks at 6945, 5747, and 5160 cm(-1) in the regression vector were consistent with those in oren powder extracts. NIR spectroscopy combined with chemometrics offers promise as a method of predicting the oren powder content in suppositories without destroying the samples.

Rapid Classification of Turmeric Based on DNA Fingerprint by Near-Infrared Spectroscopy Combined with Moving Window Partial Least Squares-Discrimination Analysis

“…Subsequently, near-infrared (NIR) spectroscopy is a very promising technique, and has been verified to be rapid identification and quantification techniques, for various herbs and herbal medicines. [12][13][14][15][16] In our previous studies of turmeric by NIR spectroscopy, we evolved the applicability of NIR to the quantitative analysis of curcuminoid in turmeric rhizomes and curcumin in turmeric herbal medicines, respectively. 17,18 The best partial least squares (PLS) calibration model for curcuminoid was developed from the second-derivative NIR spectra in the region of 2040 -2486 nm, founded by a wavelength-selection method, named moving window partial least squares (MWPLS).…”

Evaluation of Fourier Transform-Near Infrared Spectroscopic Measurements for the Quantification of Curcumin in Turmeric Herbal Medicines

“…It is primarily based on the overtone and combination bands arising from fundamental chemical vibrations and provides a rapid, non-destructive method with minimal sample preparation without the need for additional chemical reagents. The various constituents of Radix puerariae, 19 Radix pseudostellariae, 20 Ganoderma lucidum, Ganoderma atrum, 21 Paeonia lactiflora, 22 Rhizoma atractylodis macrocephalae 23 and Coptis chinensis 24 have all been investigated by NIR spectroscopy. As for turmeric, Tanaka et al 25 applied NIR analyses to determine the curcumin, desmethoxycurcumin and bisdesmethoxycurcumin contents in 37 crude medicine samples.…”

Trends in digital detection for the quality and safety of herbs using infrared and Raman spectroscopy

“…NIRS-PLS model was employed to determine two different sample presentations originating from a turmeric capsule and powder, obtaining ideal results in powder samples ( Kasemsumran et al., 2014 ). The concentration of Coptis chinensis in suppositories was also predicted ( Teraoka et al., 2012 ). Three presentations, capsule shells, contents, and intact capsules, of Yaobitong capsule, were analysed using NIRS-LSSVM model ( Si et al., 2021 ).…”