Nondestructive and on-line monitoring of tablets using light-induced fluorescence technology

Abstract

tests. This process is not only time consuming, but the solid dosage forms are destroyed. Tablets from the batch of formulation will normally be completed before the results of quantitative analysis for content uniformity of the tablets are known. If the analysis on unit dosage or content uniformity fails to satisfy the acceptance criteria, then no remedial action can be taken except to regrind, remix, and repress the tablets.

Fluorescent Sensing and Process Analytical Applications

“…48,66 While in its infancy as a process analytical technology for real -time monitoring and product parametric real -time release, the applications identifi ed and in some instances demonstrated include: (i) blend endpoint API content uniformity detection; 48 (ii) segregation monitoring or API content at various process critical control points; and (iii) at -line tablet content uniformity determination. 66 The fundamentals of solid -state luminescence spectroscopy for pharmaceutical solids has been covered by Brittain. 4 As already discussed, intrinsic LIF bioreactor monitoring is the most common application within biopharmaceutical manufacturing.…”

An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms

“…30 is based on the properties of interest and associated techniques. This overview is by no means exhaustive, but covers many important aspects of pharmaceutical manufacturing, such as chemical composition (spectroscopic techniques such as infrared [202], near infrared (NIR) [86,137,203,204], Raman [86,[204][205][206][207], UV-Vis [208], ultrasound [209,210], laser induced fluorescence [211,212] and time of flight [213]), particle size and shape (laser diffraction [214][215][216], image analysis [138], focused beam reflectance measurement [217], spatial filter velocimetry [90,218]), crystallinity and polymorphism (small-and wide-angle X-ray scattering [123,219,220], NIR [221], Raman [221][222][223]) as well as physical properties (Terahertz [224,225], optical coherence tomography [224,226], focus variation [227], ultrasound [228]). …”

Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

“…30 is based on the properties of interest and associated techniques. This overview is by no means exhaustive, but covers many important aspects of pharmaceutical manufacturing, such as chemical composition (spectroscopic techniques such as infrared [202], near infrared (NIR) [86,137,203,204], Raman [86,[204][205][206][207], UV-Vis [208], ultrasound [209,210], laser induced fluorescence [211,212] and time of flight [213]), particle size and shape (laser diffraction [214][215][216], image analysis [138], focused beam reflectance measurement [217], spatial filter velocimetry [90,218]), crystallinity and polymorphism (small-and wide-angle X-ray scattering [123,219,220], NIR [221], Raman [221][222][223]) as well as physical properties (Terahertz [224,225], optical coherence tomography [224,226], focus variation [227], ultrasound [228]). …”