Nondermatophytic onychomycosis by Fusarium oxysporum in an immunocompetent host

Shah, Shilpa; Dalal, Bhavinkumar; Modak, Meera

doi:10.1016/j.mycmed.2015.12.003

Cited by 7 publications

(9 citation statements)

References 10 publications

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“…Our research group has conducted studies involving Fusarium ‐nail relationships. We were the pioneer to prove Fusarium oxysporum was able to cause onychomycosis, including in immunocompetent individuals, and associate it with painful lesions and paronychia 7–12 . Next, we showed, for the first time, this fungus was able to use the nail as a unique nutritional source, to penetrate nail layers unassisted, in addition to being able to infect and invade across the healthy human nail through both dorsal and ventral nail surfaces 16 .…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6] In addition, the incidence of fusarial onychomycosis has increased, affecting even healthy individuals. [7][8][9][10][11][12] In our medical mycology laboratory, this rate increased from 7.5 to 13.3% in the last 15 years. 1 It is important to emphasize that besides the common damages caused by onychomycosis, 13 those provoked by Fusarium are usually accompanied by paronychia.…”

Section: Introductionmentioning

confidence: 99%

“…Fusarium oxysporum was able to cause onychomycosis, including in immunocompetent individuals, and associate it with painful lesions and paronychia. [7][8][9][10][11][12] Next, we showed, for the first time, this fungus was able to use the nail as a unique nutritional source, to penetrate nail layers unassisted, in addition to being able to infect and invade across the healthy human nail through both dorsal and ventral nail surfaces. 16 Additionally, our findings reinforced the evidence that biofilms are related to the fungal nail infection, since we produced a biofilm during the fungal growth in an ex vivo model on human nail.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, among others, the genus Fusarium has come to be a cause of onychomycosis, especially in immunocompromised patients or in the presence of already existing nail trauma 3–6 . In addition, the incidence of fusarial onychomycosis has increased, affecting even healthy individuals 7–12 . In our medical mycology laboratory, this rate increased from 7.5 to 13.3% in the last 15 years 1 …”

Section: Introductionmentioning

confidence: 99%

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Characterization of a biofilm formed by Fusarium oxysporum on the human nails

et al. 2021

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Background Fusarium spp. has been considered as an onychomycosis agent, but little is known about the etiopathogenesis of fusarial onychomycosis; thus, the objective of this study was to characterize the fungal-nail interaction and the consequences of the nail infection process by Fusarium oxysporum using the human nail, in an ex vivo model. MethodsThe kinetic of biofilm production and infection by F. oxysporum using the nail as the only nutritional source were evaluated by scanning electron microscopy, number of culturable cells, metabolic activity, characterization of extracellular matrix, spectroscopy and histopathology analyses.Results After evaluating the biofilm kinetic over 7 days using different parameters and techniques, it was possible to characterize the Fusarium-nail interaction.Conclusions This study is a part of a big project aiming to clarify the fusarial pathogenesis and contributes to proving F. oxysporum is able to adapt, grow, develop, and form a biofilm on healthy human nails, which are crucial steps for the invasion process.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of a biofilm formed by Fusarium oxysporum on the human nails

et al. 2021

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“…21 In addition, nine cases were treated with TBF or ITCZ pulse therapy; however, both drugs were only partially effective on Fusarium onychomycosis. 29 As shown in our case, physical removal or fenestration of the affected nail, 8,20,27,36,37 or topical application of antifungal agents, 8,10,12,20,21,23,24,27,38…”

Section: Clinical Type Of Onychomycosis and Fusarium Sppmentioning

confidence: 57%

Possibly the first case of onychomycosis by Fusarium lactis: Case presentation and literature review of onychomycosis by Fusarium species

Taga,

Anzawa,

Ono

et al. 2023

The Journal of Dermatology

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Fusarium species (spp.) is frequently found in soil and plant residues and on plant bodies in all climatic zones worldwide. Although there have been few reports of onychomycosis caused by Fusarium spp., it is characterized by drug sensitivity and other characteristics. Here, we report what may be the first case of onychomycosis caused by Fusarium lactis. We analyzed the mycology and characterized previously reported cases of onychomycosis caused by Fusarium spp. A 73‐year‐old otherwise healthy woman presented with discoloration and thickening of her right thumbnail with paronychia. Direct microscopy revealed unevenly swollen hyphae, and a Grocott‐stained nail specimen showed septate hyphae. Based on the morphological features and gene analysis of fungus isolated from the nail, we diagnosed onychomycosis caused by F. lactis belonging to Fusarium fujikuroi species complex. Partial nail removal and topical application of 1% luliconazole solution resolved the condition in 6 months. Minimum inhibitory concentrations for isolated F. lactis showed high sensitivity to luliconazole but not itraconazole or terbinafine. The isolated F. lactis was temperature‐sensitive. A search of the literature revealed 57 cases of onychomycosis caused by Fusarium spp. with delineated clinical characteristics. Since those cases were investigated using morphological and/or molecular methods, we analyzed them by species complex as well as species. Onychomycosis caused by Fusarium spp. is predominantly found on the big toe, with Fusarium solani species complex and Fusarium oxysporum species complex accounting for over 70% of cases. Infection of only one digit with paronychia is a characteristic clinical manifestation of onychomycosis caused by Fusarium spp. Since there has been an increase in instances of molecular determination of Fusarium spp., it is deemed necessary to clarify its clinical and fungal nature. Due to its characteristic drug sensitivity and temperature‐sensitive nature, new treatments are expected to be developed.

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