Nondegradable Antimicrobial Silver-Based Perovskite

Abstract

We synthesized nanostructured AgNbO 3 silver perovskite oxide, which prevents the proliferation of microbial cells without undergoing corrosion. The compound was tested for antimicrobial activity against Grampositive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. We confirmed that the antimicrobial activity of the compound was not related to its high dielectric and piezoelectric properties. While the measured activity, as quantified by the minimum inhibitory concentration, was similar to the activity of Ag 2 O particles subjected to the same mechanical treatments, the level of silver ion release of Ag 2 O was 60 times higher than that of AgNbO 3 . This indicated that the antimicrobial activity of AgNbO 3 is not due to corrosion resulting in silver ion release to the media.

Long-Term Prevention of Arthroplasty Infections via Incorporation of Activated AgNbO3 Nanoparticles in PMMA Bone Cement

“…To further improve bone cement performance and reduce the rate of postsurgery infections, we propose to incorporate AgNbO 3 ceramic nanoparticles in the cement formulation. These particles have been shown in our previous study to exhibit broad spectrum and permanent antimicrobial activities, and unlike other silver-based bone cement additives such as silver nanoparticles, − is corrosion resistant and has insignificant silver release rate, thus reducing the risk of its toxicity toward human cells.…”

“…These particles have been shown in our previous study to exhibit broad spectrum and permanent antimicrobial activities, 25 and unlike other silver-based bone cement additives such as silver nanoparticles, 26−28 is corrosion resistant and has insignificant silver release rate, thus reducing the risk of its toxicity toward human cells.…”

Bacterial growth dynamics on a surface having a particulate antimicrobial agent

“…At the end of the operation the beads were rinsed with deionized water and the residue thus obtained was dried inside an oven with a temperature of 150 o C overnight to obtain the final nanostructured AgNbO 3 particles. The particles were previously characterized in terms of size by the Malvern ZEN1600 Dynamic Light Scattering (DLS) machine and found to have an average size of 0.44 μm [11]. Density of the particles was measured using a AccuPyc II 1340 (Micromeritics Instruments Corp.) helium gas pycnometer.…”

“…Recently, we found a possible solution for the latter drawback by synthesizing nano-structured AgNbO 3 nanoparticles, which, despite having diminished ion release rate, show strong antimicrobial activity [11]. This kind of antimicrobial activity, which we had defined as ‘through contact’, are associated with particulate agents and can be incorporated into the surface provided that the required amount of the particles is not below a threshold.…”

Mesoporous Oxidized Mn-Ca Nanoparticles as Potential Antimicrobial Agents for Wound Healing

“…Talebpour et al have developed AgNbO3 nanoparticles that could prevent the proliferation of both Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. However, it is nondegradable, possessing a certain degree of destructiveness and environmental contamination [61]. The HMn-Ca prepared in our study effectively leverages the advantages of calcium and manganese, demonstrating the ability to inhibit both Gram-negative and Gram-positive bacteria while also promoting wound healing in bacterial-infected wounds.…”