Noncultured extracted hair follicle outer root sheath cell suspension for transplantation in vitiligo

Abstract

Extracted hair follicular ORS cell suspension can be a useful simplified transplantation method for vitiligo. The transplantation procedure should be reserved for patients with vitiligo stable for at least 1 year. A larger study is needed for further evaluation.

Clinical and treatment characteristics determining therapeutic outcome in patients undergoing autologous non‐cultured outer root sheath hair follicle cell suspension for treatment of stable vitiligo

“…Based on the studies conducted in epidermal cell suspension, the authors had speculated the cell requirement to be less than 2000 cells/cm 2 . 4,14 In the present study, we found a significant correlation between the number of melanocytes transplanted and repigmentation rate at 24 week. When assessing the clinical and treatment characteristics associated with optimal pigmentation, we found that a statistically significant higher melanocytes were transplanted in patients achieving RP > 75% (Table 1).…”

Comparative study of efficacy of epidermal melanocyte transfer versus hair follicular melanocyte transfer in stable vitiligo

“…In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo. [5]…”

“…Mohanty et al . [5] have modified the method of obtaining the follicular tissue by the FU extraction (FUE) method. They used autologous EHFORSCS for transplantation in vitiligo patients.…”

“…Noncultured autologous extracted hair follicular melanocyte transfer (HFMT) is a new addition to the prevailing techniques and it utilizes melanocytes in hair follicle instead of epidermis. [5] Since it is a novel procedure in its nascent stage, clinical trials are required to prove its efficacy in the management of stable vitiligo though theoretically it is better than existing noncultured cellular grafting techniques.…”

Spatial Peculiarities of Stem Cells in Plants and Animals

“…'Adult' stem cells include haematopoietic stem cells [40] , bone marrow stromal (mesenchymal) stem cells [41] , neural stem cells [42] dermal and hair follicular (keratinocyte and melanocyte) stem cells [43][44][45][46] , fetal cord blood stem cells [47] and several others [48] . Like Embryonic stem cells, they are capable of self-renewal throughout the organism's life, and also capable of differentiating into different mature cell types.…”