Noncovalent interactions and coordination reactions in the systems consisting of copper(II) ions, aspartic acid and diamines

Bregier-Jarzebowska, R.; Gasowska, A.; Jastrząb, Renata; Lomozik, Lechoslaw

doi:10.1016/j.jinorgbio.2009.07.001

Cited by 23 publications

(21 citation statements)

References 40 publications

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“…The pH ranges of the complex dominance in the distribution diagram of the species are practically the same as for systems of higher concentrations of metal ions and ligands. Significant changes in the chemical shifts were observed only in the pH ranges in which the complexes were present (determined on the basis of potentiometric measurements), as discussed earlier [36][37][38].…”

Section: Spectral Investigation Of Cu(ii)/lysine Systemmentioning

confidence: 60%

Interactions of histone amino acid: lysine with copper(II) ions and adenosine 5′-triphosphate as well as in a metal-free system

Bregier-Jarzebowska

Gasowska

Lomozik

2014

Journal of Coordination Chemistry

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Thermodynamic stability and mode of coordination were studied in the binary system of copper(II)/ lysine, ternary system of copper(II)/ATP/lysine, and compared to the intermolecular interaction in the metal-free ATP/lysine system. In the system ATP/Lys, groups P β and P γ from ATP, participate in the interaction with the amino acid, while group P α from ATP is involved as reaction center only at high pH. The endocyclic nitrogens from the nucleotide N(1) and N(7) take part in the interactions only below physiological pH. In the binary complexes, oxygens from carboxylic group and nitrogen from the α-NH 2 amino group are involved in coordination. However, introduction of the second ligand, ATP, into the system Cu(II)/Lys changes the amino acid coordination in alkaline medium. In protonated mixed-ligand complexes, the α, β, and γ oxygens of the phosphate from ATP coordinate, but at higher pH, only α oxygens coordinate in Cu(ATP)(Lys). Although Cu(II) ions do not coordinate nitrogen from ATP in the ternary system, the presence of metal ions excludes interaction of these atoms over the whole pH range studied.

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Section: Spectral Investigation Of Cu(ii)/lysine Systemmentioning

confidence: 60%

Interactions of histone amino acid: lysine with copper(II) ions and adenosine 5′-triphosphate as well as in a metal-free system

Bregier-Jarzebowska

Gasowska

Lomozik

2014

Journal of Coordination Chemistry

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“…Potentiometric titrations were carried out using a Titrando 905 Metrohm (Herisau, Switherland) equipped with an autoburette using an i-electrode Metrohm 6.0280.300 calibrated in terms of hydrogen ion concentration [42][43][44][45][46][47]. The pH-meter indication was corrected using 2 standard buffer solutions of pH 4.00 and pH 9.22 at 20 ± 1 • C. All potentiometric titrations were performed in an inert gas atmosphere (helium-ultra high purity).…”

Section: Equilibrium Studymentioning

confidence: 99%

“…For each studied system, 8 or more titrations were performed, and 150-350 points from each titration curve were used for computer analyses. The protonation constants of the tartaric acid and stability constants of the complexes were determined using the Hyperquad 2003 computer program [31,[42][43][44]. The calculations allowed the determination of the types (stoichiometry) and thermodynamic stability of the complexes formed in the systems studied.…”

Section: Equilibrium Studymentioning

confidence: 99%

Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems

et al. 2020

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Binary complexes of tartaric acid with lanthanide(III) ions were investigated. The studies have been performed in aqueous solution using the potentiometric method with computer analysis of the data for detection of the complexes set, determination of the stability constants of these compounds. The mode of the coordination of complexes found was determined using spectroscopy, which shows: Infrared, circular dichroism, ultraviolet, visible as well as luminescence spectroscopy. The overall stability constants of the complexes as well as the equilibrium constants of the reaction were determined. Analysis of the equilibrium constants of the reactions and spectroscopic data allowed the effectiveness of the carboxyl groups in the process of complex formation.

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“…Metal complexes play a vital role in nature, they have been extensively used in clinical applications as enzyme inhibitors [4], anti-bacterial [5], anti-viral [6] and anti-cancerous [7]. L-Aspartic acid (Asp) is one of the naturally occurring α-amino acids, with an additional carboxylic group in the side chain [8]. Asp takes part in the thermogenic processes induced by prostaglandin E1, it is a component of the active center of some enzymes [9] and forms complexes with almost all the metal ions through its three binding sites.…”

Section: Introductionmentioning

confidence: 99%

Binary Complexes of Aspartic Acid with Some Metal Ions in Aqueous Solution and Water-dioxane Mixtures

Ghiamati

Baniasadi

Farrokhi

2017

CSIJ

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The reaction between amino acids and metal ions has been used as a model for transferring the metallic ions to body tissues. How stable these complexes are formed is our concern. The stability constants of the complexes between L-aspartic acid (Asp) and Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ce(III) metal ions were determined by potentiometric titrations in aqueous solution and in 25-75%(v/v) of water-dioxane mixtures(I = 0.1 M, NaNO 3) at 15, 20, 25, 35, and 45°C.The observed increasing stability order for the corresponding complexes in water and water-dioxane mixtures were as follows: K f Cd (II)-Asp < K f Zn (II)-Asp < K f Co (II)-Asp < K f Ni (II)-Asp < K f Ce(III)-Asp < K f Cu(II)-Asp Mixed solvents such as water-dioxane provide a better model for in vivo reactions. It was observed that with increase in the percentage of dioxane, the stability constants were elevated. The results showed that the reactions were exothermic and spontaneous.

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Noncovalent interactions and coordination reactions in the systems consisting of copper(II) ions, aspartic acid and diamines

Cited by 23 publications

References 40 publications

Interactions of histone amino acid: lysine with copper(II) ions and adenosine 5′-triphosphate as well as in a metal-free system

Interactions of histone amino acid: lysine with copper(II) ions and adenosine 5′-triphosphate as well as in a metal-free system

Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems

Binary Complexes of Aspartic Acid with Some Metal Ions in Aqueous Solution and Water-dioxane Mixtures

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