Noncovalent interaction-assisted polymeric micelles for controlled drug delivery

Ding, Jianxun; Chen, Linghui; Xiao, Chunsheng; Chen, Li; Zhuang, Xiuli; Chen, Xuesi

doi:10.1039/c4cc03153a

Cited by 167 publications

(133 citation statements)

References 169 publications

(205 reference statements)

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“…Over the past decades, several nano-sized DDSs have been developed and applied by targeted drug delivery to cancer cells, such as liposomes, [4][5][6][7] polymeric micelles, [8][9][10][11] dendrimers, [12][13][14][15][16] carbon nanotubes, [17][18][19][20][21][22] inorganic nanoparticles, [23][24][25][26] and silica-based materials. [27][28][29][30][31] Among them, mesoporous silica nanoparticles (MSNs) have attracted much attention due to their unique physiochemical properties, such as large specific surface area and pore volume, controllable particle size, remarkable stability and biocompatibility, and high drug-loading capacity.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

189

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Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

189

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“…37 It is also investigated that the drug whose active site is covalently bound to the surface of NPs are observed not to undergo controlled drug release readily as compared with drugs encapsulated by following noncovalent interactions. 38 Therefore for controlled and targeted delivery, formulation of nanocarriers with noncovalent interactions may be the probable method of preserving the active ingredients and structural integrity of the materials as much as possible. Hence, the nonchemical methods adopted in this work follows simple ultrasonication, centrifugation, and controlled pH.…”

mentioning

confidence: 99%

Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Bwatanglang¹,

Mohammad²,

Yusof³

et al. 2016

IJN

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In this study, we synthesized a multifunctional nanoparticulate system with specific targeting, imaging, and drug delivering functionalities by following a three-step protocol that operates at room temperature and solely in aqueous media. The synthesis involves the encapsulation of luminescent Mn:ZnS quantum dots (QDs) with chitosan not only as a stabilizer in biological environment, but also to further provide active binding sites for the conjugation of other biomolecules. Folic acid was incorporated as targeting agent for the specific targeting of the nanocarrier toward the cells overexpressing folate receptors. Thus, the formed composite emits orange–red fluorescence around 600 nm and investigated to the highest intensity at Mn 2+ doping concentration of 15 at.% and relatively more stable at low acidic and low alkaline pH levels. The structural characteristics and optical properties were thoroughly analyzed by using Fourier transform infrared, X-ray diffraction, dynamic light scattering, ultraviolet-visible, and fluorescence spectroscopy. Further characterization was conducted using thermogravimetric analysis, high-resolution transmission electron microscopy, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray fluorescence, and X-ray photoelectron spectroscopy. The cell viability and proliferation studies by means of MTT assay have demonstrated that the as-synthesized composites do not exhibit any toxicity toward the human breast cell line MCF-10 (noncancer) and the breast cancer cell lines (MCF-7 and MDA-MB-231) up to a 500 µg/mL concentration. The cellular uptake of the nanocomposites was assayed by confocal laser scanning microscope by taking advantage of the conjugated Mn:ZnS QDs as fluorescence makers. The result showed that the functionalization of the chitosan-encapsulated QDs with folic acid enhanced the internalization and binding affinity of the nanocarrier toward folate receptor-overexpressed cells. Therefore, we hypothesized that due to the nontoxic nature of the composite, the as-synthesized nanoparticulate system can be used as a promising candidate for theranostic applications, especially for a simultaneous targeted drug delivery and cellular imaging.

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“…It is worth mentioning that the fluorescence intensities of tumor and test organs were observed to fall in the free EPI group when the time extended from 6 to 12 h, while that in the mPEG-b-PGA/EPI group increased somewhat. The different changes indicated that the micellization was able to improve the pharmacokinetic character of free drug and made them metabolize longer [16,35]. More meaningfully, the tumor fluorescence intensity of mouse treated with mPEG-b-PGA/EPI for 6 h is stronger than that with free EPI, and the distinction was more obvious at 12 h post-injection.…”

Section: Improved Tissue Distribution and Enhanced Antitumor Efficacymentioning

confidence: 70%

Epirubicin-Complexed Polypeptide Micelle Effectively and Safely Treats Hepatocellular Carcinoma

Ding

et al. 2015

Polymers

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Epirubicin (EPI) once acted as a main agent for HCC chemotherapy. However, the dosage-dependent side effects seriously limit its application in clinic. The purpose of this study is to develop an effective nanocarrier to improve the efficacy and overcome the limitations of EPI. In this regard, the EPI-complexed micelle (i.e., mPEG-b-PGA/EPI) was prepared via the electrostatic interaction between the amino group in EPI and the carboxyl group in PGA segment of methoxy poly(ethylene glycol)-block-poly(L-glutamic acid) (mPEG-b-PGA), and the subsequent hydrophobic interaction among PGA/EPI complexes. The micelle appeared spherical with a diameter at around 90 nm and possessed a pH-sensitive release property of payload. The cytotoxicity and hemolysis assays in vitro, and the maximum tolerated dose tests in vivo confirmed that mPEG-b-PGA was a kind of safe material with excellent biocompatibility, while the drug-loaded micelle could obviously improve the tolerance of EPI. In addition, mPEG-b-PGA/EPI possessed significantly enhanced antitumor efficacy and security toward the H22-xenografted HCC murine model at macroscopic and microscopic levels compared with free EPI. All these results strongly indicate that mPEG-b-PGA/EPI may be a promising nanoplatform for EPI delivery in the chemotherapy of HCC.

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Noncovalent interaction-assisted polymeric micelles for controlled drug delivery

Cited by 167 publications

References 169 publications

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Epirubicin-Complexed Polypeptide Micelle Effectively and Safely Treats Hepatocellular Carcinoma

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