Noncovalent induced circular dichroism sensors based on a chiral metal–organic framework: chiral induction synthesis, quantitative enantioselective sensing and noncovalent sensing mechanism

Abstract

As an important class of chiral optical sensor, chiral induced circular dichroism (ICD) sensors have received increasing attention. Herein, a series of monometallic and bimetallic centered metal-organic frameworks (MOFs) with...

Chiral Metal‐Organic Frameworks with Spectroscopic Methods: Towards Chemical Sensor Devices

“…A disadvantage of CD spectroscopy, however, is that quantification of a chiral mixture is challenging with the linear response region restricted between a narrow concentration range. The majority of studies involving CD have focused on the detection of biomolecules including the enantiomers of amino acids: [31] tryptophan, [33,44] proline [31] and glucose. [45] Relatively little work has been done in the development of chiral induced circular dichroism (ICD) sensors with metalorganic frameworks.…”

“…Greater sensitivity and selectivity of the sensor can be obtained when there is coordination of the analyte with the metal ion of the MOF, engendering a larger chiral effect on the sensing system. [44] The ordered nature of coordination polymers and MOFs was used to excellent effect in a Ag(I) coordination polymer synthesised using N-benzoyl-Lcysteine ethyl ester with a boronic acid group where detection of L-or D-glucose occurred across two boronic acid groups. The binding of the glucose analyte to two boronic acid groups enhanced the sensitivity of the system due to the characteristic CD and absorption signals obtained from the optimal Ag + •••Ag + interactions.…”

“…The binding of the glucose analyte to two boronic acid groups enhanced the sensitivity of the system due to the characteristic CD and absorption signals obtained from the optimal Ag + •••Ag + interactions. [45] Other systems analysed with ICD sensors include the enantiomers of chiral aromatic amino alcohols (2-phenylglycinol and (À )-cis-1-amino-2-indanol), [44] tryptophan, [44] and BINOL. [46]…”

A stable Mn(ii) coordination polymer demonstrating proton conductivity and quantitative sensing of oxytetracycline in aquaculture

“…Guided by the above ideas, metal phosphonate materials are attractive due to the following properties: (i) compared with other CPs, metal phosphonates exhibit higher stability because of the strong coordination capabilities of –PO 3 H 2 groups; 39 (ii) the –PO 3 H 2 groups can supply a multitude of protons and interact with H 2 O molecules, further forming the hydrogen bond network that can efficiently transport protons; 22,40–43 (iii) the absorption wavelength of OTC (250–400 nm) overlaps with that of the transition metal phosphonates (280–350 nm), which is expected to achieve the turn-off detection of OTC by competitive absorption mechanism; and (iv) metal phosphonates have displayed high proton conductivity and specific fluorescence sensing for small molecules, ions, and temperature, which provide the possibility for constructing multifunctional materials that combine proton conduction and fluorescence sensing. 44–48 Therefore, metal phosphonate materials provide ample possibility for designing highly stable multifunctional materials that simultaneously possess the fluorescence detection of OTC and high proton conductivity.…”

Isostructural chiral metal–organic frameworks with metal-regulated performances for electrochemical enantiomeric recognition of tyrosine and tryptophan

“…Chirality is one of the intrinsic characteristics of nature and has been found in most bioactive substances. 1,2 Amino acid molecules are the fundamental building blocks of enzymes and proteins and play an essential role in living organisms. Chiral amino acids have l and d enantiomers, of which only one could have an effective and positive influence on the construction of organisms or disease treatment, whereas another one is ineffective or even toxic in many cases.…”